Nottingham Trent University

About: Nottingham Trent University is a education organization based out in Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Addiction. The organization has 4702 authors who have published 12862 publications receiving 307430 citations. The organization is also known as: NTU & Trent Polytechnic.

Can critical management studies ever be ‘practical’? A case study in engaged scholarship

Abstract: What happens when you try to engage with management practice as a critical management scholar by actually doing management? Although there have been calls for critical scholars to attempt such engagement, little is known about the practical challenges and learning that may be involved. This article therefore provides a case study that details some of the experiences one of us had when working as a manager while trying to remain true to his critical sensibilities. The story suggests that transforming management practice will be a constant struggle, and that the difficulties of achieving even small changes should not be underestimated. However, change is not impossible. Following Foucault, we argue that critical perspectives, when engaged in particular ways, offer resources through which we might challenge the dominance of managerialist thinking on a practical level − at least in the long run.

MicroRNA signature analysis in colorectal cancer: identification of expression profiles in stage II tumors associated with aggressive disease.

Abstract: Colorectal cancer (CRC) is a clinically diverse disease whose molecular etiology remains poorly understood. The purpose of this study was to identify miRNA expression patterns predictive of CRC tumor status and to investigate associations between microRNA (miRNA) expression and clinicopathological parameters. Expression profiling of 380 miRNAs was performed on 20 paired stage II tumor and normal tissues. Artificial neural network (ANN) analysis was applied to identify miRNAs predictive of tumor status. The validation of specific miRNAs was performed on 102 tissue specimens of varying stages. Thirty-three miRNAs were identified as differentially expressed in tumor versus normal tissues. ANN analysis identified three miRNAs (miR-139-5p, miR-31, and miR-17-92 cluster) predictive of tumor status in stage II disease. Elevated expression of miR-31 (p = 0.004) and miR-139-5p (p < 0.001) and reduced expression of miR-143 (p = 0.016) were associated with aggressive mucinous phenotype. Increased expression of miR-10b was also associated with mucinous tumors (p = 0.004). Furthermore, progressively increasing levels of miR-10b expression were observed from T1 to T4 lesions and from stage I to IV disease. Association of specific miRNAs with clinicopathological features indicates their biological relevance and highlights the power of ANN to reliably predict clinically relevant miRNA biomarkers, which it is hoped will better stratify patients to guide adjuvant therapy.

Testing normative and self-appraisal feedback in an online slot-machine pop-up in a real-world setting

Abstract: Over the last few years, there have been an increasing number of gaming operators that have incorporated on-screen pop-up messages while gamblers play on slot machines and/or online as one of a range of tools to help encourage responsible gambling. Coupled with this, there has also been an increase in empirical research into whether such pop-up messages are effective, particularly in laboratory settings. However, very few studies have been conducted on the utility of pop-up messages in real-world gambling settings. The present study investigated the effects of normative and self-appraisal feedback in a slot machine pop-up message compared to a simple (non-enhanced) pop-up message. The study was conducted in a real-world gambling environment by comparing the behavioral tracking data of two representative random samples of 800,000 gambling sessions (i.e., 1.6 million sessions in total) across two conditions (i.e., simple pop-up message versus an enhanced pop-up message). The results indicated that the additional normative and self-appraisal content doubled the number of gamblers who stopped playing after they received the enhanced pop-up message (1.39%) compared to the simple pop-up message (0.67%). The data suggest that pop-up messages influence only a small number of gamblers to cease long playing sessions and that enhanced messages are slightly more effective in helping gamblers to stop playing in-session.

Is there evidence of learned helplessness in horses

Abstract: Learned helplessness can be defined as a psychological condition whereby individuals learn that they have no control over unpleasant or harmful conditions, that their actions are futile and that they are helpless. In a series of experiments in which dogs were exposed to inescapable shocks it was found that this lack of control subsequently interfered with the ability to learn an avoidance task. There is evidence that both neural adaptations and behavioural despair occur in response to uncontrollable aversive experiences in rodents, although this has yet to be demonstrated in other species such as horses. However, it has been suggested that certain traditional methods of horse training and some behavioral modification techniques may involve aversive conditions over which the horse has little or no control. When training and management procedures are repeatedly unpleasant for the horse and there is no clear association between behavior and outcome, this is likely to interfere with learning and performance, in addition to compromising welfare. This paper reviews published literature and anecdotal evidence to explore the possibility that the phenomenon ‘learned helplessness’ occurs in the horse.