Nottingham Trent University

About: Nottingham Trent University is a education organization based out in Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 4702 authors who have published 12862 publications receiving 307430 citations. The organization is also known as: NTU & Trent Polytechnic.

New insights on the genetic etiology of Alzheimer’s and related dementia

Abstract: Alzheimer’s disease (AD) is a severe and incurable neurodegenerative disease, and the failure to find effective treatments suggests that the underlying pathology remains poorly understood. Due to its strong heritability, deciphering the genetic landscape of AD and related dementia (ADD) is a unique opportunity to advance our knowledge. We completed a meta-analysis of genome-wide association studies (39,106 clinically AD-diagnosed cases, 46,828 proxy-ADD cases and 401,577 controls) with the most promising signals followed-up in 25,392 independent AD cases and 276,086 controls. We report 75 risk loci for ADD, including 42 novel ones. Pathway-enrichment analyses confirm the involvement of amyloid/Tau pathways, highlight the role of microglia and its potential interaction with APP metabolism. Numerous genes exhibited differential expression or splicing in AD-related conditions and gene prioritization implies EGFR signaling and TNF-α pathway through LUBAC complex. We also generated a novel polygenic risk score strongly associated with the risk of future dementia or progression from mild cognitive impairment to dementia. In conclusion, by more than doubling the number of loci associated with ADD risk, our study offers new insights into the pathophysiological processes underlying AD and offers additional therapeutic entry-points and tools for translational genomics.

Change in drag, apparent slip and optimum air layer thickness for laminar flow over an idealised superhydrophobic surface

Abstract: Analytic results are derived for the apparent slip length, the change in drag and the optimum air layer thickness of laminar channel and pipe flow over an idealised superhydrophobic surface, i.e. a gas layer of constant thickness retained on a wall. For a simple Couette flow the gas layer always has a drag reducing effect, and the apparent slip length is positive, assuming that there is a favourable viscosity contrast between liquid and gas. In pressure-driven pipe and channel flow blockage limits the drag reduction caused by the lubricating effects of the gas layer; thus an optimum gas layer thickness can be derived. The values for the change in drag and the apparent slip length are strongly affected by the assumptions made for the flow in the gas phase. The standard assumptions of a constant shear rate in the gas layer or an equal pressure gradient in the gas layer and liquid layer give considerably higher values for the drag reduction and the apparent slip length than an alternative assumption of a vanishing mass flow rate in the gas layer. Similarly, a minimum viscosity contrast of four must be exceeded to achieve drag reduction under the zero mass flow rate assumption whereas the drag can be reduced for a viscosity contrast greater than unity under the conventional assumptions. Thus, traditional formulae from lubrication theory lead to an overestimation of the optimum slip length and drag reduction when applied to superhydrophobic surfaces, where the gas is trapped.

The effectiveness of vehicle security devices and their role in the crime drop

Abstract: Car theft in the UK fell two-thirds from the mid-1990s as part of more widespread crime drops, and has been attributed to improved vehicle security. This study develops a Security Impact Assessment Tool (SIAT) to gauge the contribution of individual security devices and their combination. The metric of impact derived is termed the Security Protection Factor (SPF). Cars with central locking plus an electronic immobilizer, and often an alarm, are found to be ‘SPF 25’, that is, they were up to 25 times less likely to be stolen than those without security. That impact is greater than expected from the individual contributions of those devices, and is attributed to interaction effects. Tracking devices are found to be particularly effective but rarer. Protective effects were greater against theft of cars than against theft from cars or attempts, almost certainly reflecting the difficulty imposed on thieves by electronic immobilizers. It is suggested that this type of analysis could be usefully extended to other crime types and security combinations. The analysis also lends support to a ‘security hypothesis’ component of an explanation for the major national and international crime drops that is based in the criminologies of everyday life.

Depression, Internet Gaming Disorder, and the Moderating Effect of the Gamer-Avatar Relationship: an Exploratory Longitudinal Study

Abstract: Research into Internet gaming disorder (IGD) literature largely uses cross-sectional designs and seldom examines gaming context-related factors. Therefore, the present study combined a cross-sectional and longitudinal design to examine depression and the gamer-avatar relationship (GAR) as risk factors in the development of IGD among emerging adults. IGD behaviors of 125 gamers (64 online gamers, Mage = 23.3 years, SD = 3.4; 61 offline gamers, Mage = 23.0 years, SD = 3.4) were assessed using the nine-item Internet Gaming Disorder Scale Short Form (IGDS-SF9; Pontes and Griffiths Revista Argentina de Ciencias del Comportamiento, 7, 102–118, 2015a; Computers in Human Behavior, 45, 137–143, 2015b). The Self-Presence Scale (Ratan and Dawson Communication Research, 2015) and the Beck Depression Inventory (Beck et al. 1996) were also used to assess gamers’ levels of GAR and depressive symptoms, respectively. Regression and moderation analyses revealed that depression and the GAR act as individual risk factors in the development of IGD over time. Furthermore, the GAR exacerbates the IGD risk effect of depression.

The State, Skilled Labour Markets, and Immigration: The Case of Doctors in England

Abstract: Most recent research on skilled migration focuses on those working in the financial sectors and there has been very little work in Europe on the migration of people in welfare sectors. In this paper we seek to explore some of the complexities of shifting labour markets and immigration regulations and their influence on the geography of migration of doctors to England. We argue that state regulations, both of immigration and those governing the medical labour force, have been altered to meet the specificities of internal labour-market shortages and that the level of the state remains a useful analytical level for understanding the skilled migration of doctors.