Nottingham Trent University

About: Nottingham Trent University is a education organization based out in Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 4702 authors who have published 12862 publications receiving 307430 citations. The organization is also known as: NTU & Trent Polytechnic.

Industry 4.0 and circular economy: Operational excellence for sustainable reverse supply chain performance

Abstract: The present research proposes a roadmap to the excellence of operations for sustainable reverse supply chain/logistics by the joint implementation of principles of Industry 4.0 (I4.0) and ReSOLVE model of circular economy (CE) approaches. The connection between I4.0 and CE is unveiled by addressing the case-based model affecting the economic and environmental performances imparting two important dimensions: (i) the information sharing with the reverse logistics system is in real-time mode, and (ii) diffusion of green product in the market. The effectiveness of the virtual world in I4.0 environment is explored using simulation of reverse logistics model involving operations such as inventory and production planning policy, family-based dispatching rules of remanufacturing, and additive manufacturing. The remanufacturing model examines the trade-off between set-up delays and the availability of green transportation. For managerial insights, Taguchi experimental design framework has been used for the analysis. Based on the trade-off analysis between environmental and economic performances, the findings of the paper suggest appropriate combinations of information-sharing and family-based dispatching rules. Further, the findings suggest that, given the I4.0 and circular capabilities, it is necessary to focus on the cost of the socially influenced operations involving factors such as collection investment and size of the end-user market that governs the product returns. Therefore, in the present paper, the integration of I4.0 and CE represents a real-time decision model for the sustainable reverse logistics system.

An overview of the fundamentals of the chemistry of silica with relevance to biosilicification and technological advances

Abstract: Biomineral formation is widespread in nature, and occurs in bacteria, single-celled protists, plants, invertebrates, and vertebrates. Minerals formed in the biological environment often show unusual physical properties (e.g. strength, degree of hydration) and often have structures that exhibit order on many length scales. Biosilica, found in single-celled organisms through to higher plants and primitive animals (sponges), is formed from an environment that is undersaturated with respect to silicon, and under conditions of approximately neutral pH and relatively low temperatures of 4-40 °C compared to those used industrially. Formation of the mineral may occur intracellularly or extracellularly, and specific biochemical locations for mineral deposition that include lipids, proteins and carbohydrates are known. In most cases, the formation of the mineral phase is linked to cellular processes, an understanding of which could lead to the design of new materials for biomedical, optical and other applications. In this contribution, we describe the aqueous chemistry of silica, from uncondensed monomers through to colloidal particles and 3D structures, that is relevant to the environment from which the biomineral forms. We then describe the chemistry of silica formation from alkoxides such as tetraethoxysilane, as this and other silanes have been used to study the chemistry of silica formation using silicatein, and such precursors are often used in the preparation of silicas for technological applications. The focus of this article is on the methods, experimental and computational, by which the process of silica formation can be studied, with an emphasis on speciation.

Chemokines induce migrational responses in human breast carcinoma cell lines

Abstract: Chemokines have been shown to chemoattract and activate different leukocyte populations. Here we report the in vitro effect of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, regulated on activation, normal T-cells, expressed and secreted (RANTES), monocyte chemotactic protein-1 (MCP-1), interleukin-8 (IL-8), interferon inducible protein-10 (IP-10), neutrophil-activating peptide-2 (NAP-2), growth-related protein (GRO)-alpha and GRO-gamma, on the migration of 3 human breast carcinoma cell lines, MCF-7, T47D and ZR-75-1, using a microchemotaxis chamber to assess migration across fibronectin-coated polycarbonate membranes. MCF-7 cells responded chemotactically to all chemokines tested in a pattern which was dose and time dependent, although responses to the different chemokines were variable. ZR-75-1 responded to MIP-1beta and GRO-alpha, giving maximum migration indices of 3.7 and 5.3, respectively, and exhibited a migratory response to MIP-1alpha, IL-8 and MCP-1 although to a lower degree. T47D was unresponsive to the chemokines tested, but both MCF-7 and T47D cells bound radiolabelled ligands with binding constants (Kd) ranging from 0.6 to 2.2 nM and 0.6 to 2.1 nM, respectively. The specificity of the chemotactic response of MCF-7 to MIP-1alpha and MIP-1beta was confirmed using chemokine-specific neutralising antibodies and heat denaturation, and was demonstrated to involve G protein and cyclic AMP signalling pathways. MIP-1beta and MIP-1alpha were shown to induce changes in the organisation of the actin cytoskeleton and the level of F-actin in MCF-7 cells, as determined using flow cytometric analysis and confocal microscopy. Our results show that breast carcinoma cells can respond to chemokines, and suggests a potential role for these molecules in the process of tumour cell migration, invasion and metastasis.

Entrepreneurship, innovation and regional growth: a network theory

Abstract: Despite the growing acknowledgement that entrepreneurship is an important driver of regional innovation and growth, the role of the networks in these processes has been less formally examined. In order to address this gap, this paper proposes that the relationship between entrepreneurship, innovation and regional growth is governed by a series of network dynamics. Drawing upon aspects of endogenous growth theory and the knowledge spillover theory of entrepreneurship, it is proposed that the nature of the networks formed by entrepreneurial firms is a key determinant of regional growth differentials. In particular, network capital, in the form of investments in strategic relations to gain access to knowledge, is considered to mediate the relationship between entrepreneurship and innovation-based regional growth. It is suggested that network dynamics should be further incorporated into theories concerning the link between knowledge spillovers, entrepreneurship and regional growth. The paper concludes with a series of theoretical, entrepreneurial and policy implications emerging from the study.

A Nitrogen-Rich 2D sp 2 -Carbon-Linked Conjugated Polymer Framework as a High-Performance Cathode for Lithium-Ion Batteries

Abstract: A two-dimensional (2D) sp2 -carbon-linked conjugated polymer framework (2D CCP-HATN) has a nitrogen-doped skeleton, a periodical dual-pore structure and high chemical stability. The polymer backbone consists of hexaazatrinaphthalene (HATN) and cyanovinylene units linked entirely by carbon-carbon double bonds. Profiting from the shape-persistent framework of 2D CCP-HATN integrated with the electrochemical redox-active HATN and the robust sp2 carbon-carbon linkage, 2D CCP-HATN hybridized with carbon nanotubes shows a high capacity of 116 mA h g-1 , with high utilization of its redox-active sites and superb cycling stability (91 % after 1000 cycles) and rate capability (82 %, 1.0 A g-1 vs. 0.1 A g-1 ) as an organic cathode material for lithium-ion batteries.