Nottingham Trent University

About: Nottingham Trent University is a education organization based out in Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 4702 authors who have published 12862 publications receiving 307430 citations. The organization is also known as: NTU & Trent Polytechnic.

Enterobacter sakazakii and other bacteria in powdered infant milk formula.

Abstract: Recently there has been considerable concern related to the presence of bacteria, in particular Enterobacter sakazakii, in powdered infant formula milk. This paper considers the bacteria in these products at point of sale, with reference to current microbiological testing and the need for good hygienic practice in their subsequent preparation before feeding. The ingestion of raised numbers of E. sakazakii resulting from temperature abuse after reconstitution is highlighted as well as the uncertain routes of E. sakazakii product contamination.

A Network-based view of regional growth

Abstract: The need to better understand the mechanisms underlying regional growth patterns is widely recognized. This article argues that regional growth is partly a function of the value created through inter-organizational flows of knowledge within and across regions. It is proposed that investment in calculative networks by organizations to access knowledge is a form of capital, termed network capital, which should be incorporated into regional growth models. The article seeks to develop a framework to capture the value of network capital within these models based on the spatial configuration and the nature of the knowledge flowing through networks.

The Cambridge handbook of communication disorders

Abstract: Many children and adults experience impairment of their communication skills. These communication disorders impact adversely on all aspects of these individuals’ lives. In thirty dedicated chapters, The Cambridge Handbook of Communication Disorders examines the full range of developmental and acquired communication disorders and provides the most up-to-date and comprehensive guide to the epidemiology, aetiology and clinical features of these disorders. The volume also examines how these disorders are assessed and treated by speech and language therapists and addresses recent theoretical developments in the fi eld. The handbook goes beyond wellknown communication disorders to include populations such as children with emotional disturbance, adults with non-Alzheimer’s dementias and people with personality disorders. Each chapter describes in accessible terms the most recent thinking and research in communication disorders. The volume is an ideal guide for academic researchers, graduate students and professionals in speech and language therapy.

Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.

Abstract: 'Tissue' transglutaminase (tTG) selectively accumulates in cells undergoing apoptosis both in vivo and in vitro. Considering the central role played by mitochondria in apoptosis, we investigated the relationships existing amongst tTG expression, apoptosis and mitochondrial function. To this aim we studied the mechanisms of apoptosis in a neuronal cell line (SK-N-BE (2)) in which the tTG-expression was driven by a constitutive promoter. Furthermore, a tet-off inducible promoter was also used in 3T3 fibroblastic cells used as control. Both cell lines, when expressing tTG, appeared 'sensitized' to apoptosis. Strikingly, we found major differences in the morphological features of mitochondria among cell lines in the absence of apoptotic stimuli. In addition, these ultrastructural characteristics were associated with specific functional features: (i) constitutively hyperpolarized mitochondria and (ii) increased reactive oxygen intermediates production. Importantly, after mitochondrial-mediated apoptosis by staurosporine, a rapid loss of mitochondrial membrane potential was found in tTG cells only. Taken together, these results seem to suggest that, via hyperpolarization, tTG might act as a 'sensitizer' towards apoptotic stimuli specifically targeted to mitochondria. These results could also be of pathogenetic relevance for those diseases that are characterized by increased tTG and apoptotic rate together with impaired mitochondrial function, e.g. in some neurodegenerative disease.

Strategic Practice, 'Discourse' and the Everyday Interactional Constitution of 'Power Effects':

Abstract: This paper responds to the empirical and analytical challenge that surrounds tracing the constitution of 'power effects of corporate strategy discourse' notably documented in Knights and Morgan's seminal contribution. To meet the empirical challenge,interaction is centralized and ethnographies of strategists at-work are extended to include audiorecording their naturally occurring talk-based interactive routines over time/space. To meet the analytical challenge, the paper turns to two distinct social science traditions—Habermas' critical social theory and ethnostudies set against the stance of 'supplementation'. Habermas' schema suggests a re-conceptualization of strategic practice as a process where strategists routinely draw upon four forms of knowledge, which arguably 'makes-up' any 'Discourse'. These knowledges concern the external, social and subjective domain with the overarching knowledge being language use. Each also raises associated validity claims. While brief, the ethnomethodological perspectiv...