Showing papers by "Novartis published in 1970"

Human calcitonin. VI. Synthesis of calcitonin M

Abstract: A detailed account is given of the total synthesis of human calcitonin M, the hypocalcaemic hormone possessing the dotriacontapeptide sequence I. In the build up of I, the protected sequences 1–10 and 11–32 served as intermediates for the preparation of the protected precursor dotriacontapeptide 1–32 (II). While the synthesis of the fragment 1–10 has been reported previously [1], the present account includes a detailed description of the build up of the intermediate 11–32. Racemisation encountered in the synthesis of this fragment is discussed and conditions indicated in which it is minimized. From the final coupling step using dicyclohexylcarbodiimide-N-hydroxysuccinimide [3], the protected dotriacontapeptide II was obtained pure in a yield of 65% after counter-current distribution. In the removal by acidolysis of the protecting groups from II even under optimal conditions two side reactions occur: alkylation of the 8-methionine side chain and N to O acyl migration at the serine or threonine residues. By-products from these reactions were removed by counter-current distribution giving very pure I free of diastereoisomers and possessing the biological activity of highly purified natural calcitonin M. In the routine assay [4] after repeated testing its activity was evaluated at 100 ± 5 U/mg (calculated on content of free peptide).

Bis-methine compounds

Abstract: WHEREIN R2 and R4 each is alkylene, X is oxygen or nitrogen and R3 is alkylene which can be interrupted by an oxygen, sulfur or nitrogen atom, vinylene, ethynylene, cycloalkylene, cycloalkyldialkylene, arylene or naphthylene are useful as dyes for hydrophobic textile materials such as polyester fibers. Compounds having two cyanomethylideneaniline moieties linked together through the aniline nitrogen atom of each by a group having the formula

Diamino-s-triazines

Abstract: The disclosure covers diamino-s-triazines which are useful in polymer synthesis, such as polyimides. Also covered are dinitro-s-triazines which can be used as intermediates for the diamino compounds. The diamines are prepared by a condensation of 2-substituted-4,6-dichlorotriazines with diamines or with nitroamines. The product from the latter reaction can be reduced subsequently to diamines.

Apparatus for making prints from colour negatives

Abstract: AN APPARATUS FOR MAKING PRINTS FROM COLOUR NEGATIVES HAS ADJUSTABLE FILTERS FOR CONTROLLING THE COLOUR COMPOSITION OF THE PRINTING LIGHT WHICH ILLUMINATES THE NEGATIVE BEING PRINTED. THE REQUIRED COLOUR COMPOSITION IS DEPENDENT ON THE COLOUR DENSITIES OF THE NEGATIVE. TO MEASSURE THE COLOR DENSITIES THE PRINTING LIGHT IS SAMPLED BOTH BEFORE AND AFTER TRANSMISSION THROUGH THE NEGATIVE AND THE SAMPLES ANALYZED IN RESPECT TO THEIR PRIMARY COLOUR COMPONENTS. THE CORRESPONDING COMPONENTS OF THE LIGHT SAMPLES BEFORE AND AFTER THE NEGATIVE ARE COMPARED TO OBTAIN DIFFERENT SIGNALS REPRESENTING THE COLOUR DENSITIES OF THE NEGATIVE. THESE SIGNALS ARE USED IN TURN TO AUTOMATICALLY ADJUST THE FILTERS FOR THE CORRECT COLOUR COMPOSITION OF THE PRINTING LIGHT. A SHUTTER IS LOCATED BETWEEN THE NEGATIVE AND THE PRINTING MATERIAL AND IS OPENED TO EXPOSE THE LATTER ONCE THE PRINTING LIGHT HAS BEEN ADJUSTED. THE LIGHT SAMPLES ARE ALSO USED TO DERIVE BRIGHTNESS SIGNALS FOR CONTROLLING THE TIME FOR WHICH THE SHUTTER IS OPENED.

Reinforced plastics materials

Abstract: THE INVENTION RELATES TO PROCESS FOR PRODUCING A RESINIMPREGNATED TAPE FROM A PLURALITY OF TOWS OF FIBRES WHICH COMPRISES IMPREGNATING THE SAID TOWS WITH A SOLUTION OF A FIRST RESIN IN A VOLATILE SOLVENT, SHAPING EACH TOW INTO THE FORM OF A RIBBON OF SUBSTANTIALLY CONSTANT WIDTH, REMOVING SUBSTANTIALLY ALL THE SOLVENT FROM EACH RIBBON, ALIGNING THE IMPREGNATED RIBBONS IN AN ABUTTING EDGETO-EDGE RELATIONSHIP, AND CONTACTING THE UPPER AND LOWER SURFACES OF THE ALIGNED RIBBONS WITH A SECOND RESIN UNDER CONDITIONS SUCH THAT THE SAID SECOND RESIN FLOWS ABOUT THE RIBBONS TO FORM A COHERENT RESIN-IMPREGNATED TAPE THEREFROM.

Alkylated diphenylamines as stabilizers

Abstract: The use of tris 2,4,4''-alkyldiphenylamines for stabilizing organic material and compositions thereof especially synthetic lubricating oils. Such compositions are stabilized against oxidative deterioration.

Process for hardening water-soluble polymers

Abstract: The present invention relates to a process for hardening watersoluble polymers, especially gelatine in the form of photographic emulsions with bis-acryloylimide. This hardener combines low molecular weight with a very great hardening capacity.

Process for protecting organic material from the action of ultraviolet rays

Abstract: This invention refers to a process for protecting organic materials that can be damaged by ultraviolet rays, from the action of ultraviolet rays, wherein asymmetrical oxalic acid diarylamides of the general formula A-NH-CO-CO-NH-B where A and B are different from each other and each represents a benzene or naphthalene residue, these residues A and B (a) being free from hydroxyl groups in the ortho-positions to the amide nitrogen atom and (b) containing if desired substituents that contain no more than 20 carbon atoms and do not displace the absorption maximum of the compound towards values above 400 m mu , are applied to said materials, as well as compositions containing said oxalic acid diarylamides.

N-substituted pyrazolo-pyrimidines

Abstract: COMPOUND OF THE FORMULAE 1-R1,4-R'',6-R"-1H-PYRAZOLO(3,4-D)PYRIMIDINE AND 2-R1,4-R'' ,6-R"-2H-PYRAZOLO(3,4-D)PYRIMIDINE IN WHICH R1 STANDS FOR BRANCHED ALKYL, ALKENYL OR CYCLOALKYL HAVING AT LEAST 3 CARBON ATOMS OR HYDROXYALKYL, R'' STANDS FOR FREE OR SUBSTITUTED AMINO, HYDRAZINO, HALOGEN OR FREE OR ETHERIFIED MERCAPTO, AND R" STANDS FOR HYDROGEN, ALKYL OR FOR R'' FOR EXAMPLE: THE 1-ISOPROPYL-4-(NPROPYLAMINO)-PYRAZOLO(3,4-D)PYRIMIDINE. USE: CORONARY DILATING, DIURETIC ANALGETIC OR ANTIBACTERIAL AGENTS.

Resins produced from the reaction of epoxides and dimethylol-propionic acid

Abstract: COATING SYSTEMS APPLICABLE BY CONVENTIONAL COATING TECHNIQUES AS WELL AS BY ELECTROPHORETIC COATING ARE PROVIDED BY REACTING A HYDROXYCARBOXYLIC ACID SUCH AS DIMETHYLOPROPIONIC ACID WITH AN EPOXY RESIN AND OPTIONALLY ANY OF A DIBASIC ACID AND A DIOL IN THE ABSENCE OF AN EXTERNALLY ADDED ESTERIFICATION CATALYST AND CURING THE THUS OBTAINED PRODUCT. A VARIETY OF COATING SYSTEMS IS OBTAINED INCLUDING WATER-SOLUBLE RESINS OBTAINED BY NEUTRALIZING WITH AN AMINE THE REACTION PRODUCT PRIOR TO CURING.

10-oxo-10 11-dihydro-dibenzazepine derivative

Abstract: 10 - OXO - 10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPINE-5-CARBOXAMIDE HAS A DEPRESSANT EFFECT ON THE CENTRAL NERVOUS SYSTEM; THE COMPOUNDS IS THE ACTIVE INGREDIENT OF PHARMACEUTICAL COMPOSITIONS AND IS USEFUL FOR THE TREATMENT OF PYSCHOSOMATIC DISTURBANCES, OF EPILEPSY AND OF TRIGEMINAL NEURALGIA.

Derivatives of 7-aminocephalosporanic acid

Abstract: 7-AMINOPYRIDINIUMACETYLAMINO-CEPHALOSPORANIC ACIDS AND DERIVATIVES THEREOF. THE NEW COMPOUNDS HAVE ANTIBACTERIAL PROPERTIES.

Alpha-methylol-benzoin-sulphonic acid esters

Abstract: THE INVENTION PROVIDES NOVEL A-METHYLOL-BENZOIN-SULPHONIC ACID ESTERS WHICH MAY BE MANUFACTURED BY REACTINGG EQUIVALENT AMOUNTS OF AN A-HYDROXY-METHYLBENZOIN AND A SULPHONIC ACID ESTER CHLORIDE IN THE PRESENCE OF A HYDROGEN CHLORIDE BINDING AGENT. THE NOVEL COMPOUNDS DECOMPOSE ON IRRADIATION WITH UV LIGHT UNDER LIBERATION OF THE CORRESPONDING SULPHONIC ACID. THEREFORE, THEY ARE SUITABLE FOR USE AS CIRING CATALYSTS WHICH CAN BE ACTIVATED BY UV-RAYS FOR ACID-CURABLE RESINS OR RESIN COMPOSITIONS.

Process for the manufacture of peptides containing cystine

Abstract: Process for the manufacture of peptides containing cystine Abstract of the Disclosure Process for the manufacture of peptides which contain more than one disulphide bond characterised in that in one or two aminoacid sequences containing cysteine, in which disulphide bonds are to be produced, two cysteine radicals which are to be linked are protected by a mercapto-protective group R1 of the aralkyl type, two further cysteine radicals are protected by an acylaminomethyl group R2, the protective groups R1 are removed by treatment with iodine in the presence of a polyhalogenated lower aliphatic hydroxy compound or oxo compound, or a corresponding lower alkanoic acid lower alkyl ester, at the same time forming the disulphide bond between these cysteine radicals, which were protected by R1, and at any desired point after removal of the polyhalogenated compound the second disulphide bridge is formed in the usual manner.

Pharmaceutical compositions and methods employing substituted derivatives of 2-anilinophenylacetic acids and esters

Abstract: PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED 2-ANILINOPHENYLACETIC ACIDS, THEIR ESTERS AND SALTS HAVE DESIRABLE ABSORPTION PATTERNS FOR PROTECTING THE SKIN AGAINST THE IRRITATING EFFECT OF ULTRAVIOLET LIGHT AND ARE ALSO ANTI-INFLAMMATORYAGENTS. TYPICAL EMBODIMENTS ARE COMPOSITIONS CONTAINING 2-(2,6-DICHLOROANILINO) PHENYLACETIC ACID, THE SODIUM SALT THEREOF AND THE METHYL ESTER THEREOF.

New bis-naphthoxazolyl-derivatives

Abstract: WHEREIN U denotes a diphenyl radical bonded in the 4,4''-position to the oxazole rings and U1 and U2 denote naphthalene radicals fused to the oxazole rings, and wherein up to four positions capable of substitution in U; U1 and U2 can be substituted with optionally substituted alkyl groups, halogen or optionally functionally modified sulphonic acid groups and up to 2 positions capable of substitution can be substituted with optionally substituted phenyl groups, phenylalkyl groups, -SO2-phenyl, nitrile or optionally functionally modified carboxyl groups. The naphthoxazole compounds are useful as optical brightening agents. The present invention relates to new azole derivatives of the naphthoxazole type which in the most general case correspond to the formula

Lower alkylthiomethylene containing phenols

Abstract: Mono and dimethylene thioethers of dialkyl phenols are prepared by reacting dialkyl phenols at elevated temperatures with formaldehyde and the respective mercapto compound in an inert solvent in the presence of an alkaline compound.

Phosphinic acids and esters of alkylated p-hydroxyphenylalkanes

Abstract: Phosphinic acids and their esters of alkylated phydroxyphenylalkanes are prepared from alkylated p-hydroxyphenylalkyl halides and phosphorus halides in the presence of a complexing metal halide Lewis acid followed by a dissociation of the reaction complex with water to form the corresponding phosphinic acid or with an alcohol followed by water to form the corresponding phosphinic ester. The phosphinic acids are useful as intermediates in preparing the phosphinates which in turn are useful as stabilizers of organic materials which are subject to oxidative deterioration.

Technique for lathe grinding multifocal contact lenses

Abstract: A multifocal or bifocal contact lens is made on a convention radius turning lathe has two supports, one for the work or lens blank and the other for the tool. The tool is rotated about an axis fixed on its support so that the point of the tool describes a circle. The blank is held fixed on its support. Upon relative angular movement of the supports, a spherical segment is cut in the blank, with the center of curvature falling along the axis of rotation of the tool whereby monocentricity is achieved. By such grinding technique, a segment for near view may be formed having a desirable configuration in which nasal rotation of the lens is noncritical.

Analogues of human thyrocalcitonin modified with corresponding amino acids of salmon thyrocalcitonin and derivatives thereof

Abstract: HYPOCALCAEMIC PEPTIDE AMIDES OF THE FORMULA H-CYS-GLY-ASN-LEU-SER-THR-CYS-X-LEU-GLY-THR-TYR-THR-GLNASP-PHE-ASN-LYS-PHE -HIS-THR-PHE-PRO-GLN-THR-ALA-ILEGLY-VAL-GLY-ALA-PRO-NH2, WHERE THE CYS RESIDUES ARE JOINED. WHEREIN X REPRESENTS THE RADICAL OF L-METHIONINE, L-VALINE, L-NORVALINE, L-LEUCINE, L-ISOLEUCINE, L-NORLEUCINE OR L-A-AMINOBUTYRIC ACID AND WHEREIN AT LEAST ONE OF THE AMINOACIDS IN POSITIONS 13, 12, 16, 17, 19, 20, 22 AND 24 IS REPLACED BY ANOTHER AMONOACID, NAMELY L-THREONINE11 BY L-LYSINE, L-TYROSINE12 BY L-LEUCINE, L-PHENYLALANINE16 BY L-LEUCINE, L-ASPARAGING17 BY L-HISTIDINE, L-PHENYLALANINE19 BY L-LEUCINE, L-HISTIDINE20 BY L-GLUTAMINE, LPHENYLALANINE22 BY L-TYROSINE AND L-GLUTAMINE24 BY L-ARGININE.

N-OCTADECYL 3,5-DI-t-BUTYL-4-HYDROXYBENZOATE

Abstract: IN WHICH Y'' HAS A VALUE OF FROM SIX TO 20 INCLUSIVELY, ARE USEFUL IN THE STABILIZATION OF A VARIETY OF ORGANIC MATERIALS NORMALLY SUBJECT TO OXIDATIVE DETERIORATION. Organic polymeric substances such as polyolefins, lubricating oils, waxes and resins are among the organic materials stabilized. Alkyl dialkylhydroxybenzoates of the formula:

Carboxy terminated polyamides and diepoxides

Abstract: A curable composition which can be converted into crystalline plastics at an elevated temperature, characterized in that it contains long-chain polyamide-dicarboxylic acids of the formula IN WHICH R1 and R2 each are members selected from the group consisting of branched alkylene, linear alkylene, branched alkenylene and linear alkenylene residue, and a is an integer of at least 2, preferably 2 - 10, as well as diepoxy compounds and, if desired, also antioxidants, and in which for every epoxide group equivalent 0.7 to 1.2, preferably 0.9 to 1.1 equivalent of carboxyl groups is present.

Coupler-aspirator-valve assembly

Abstract: A coupler-aspirator-valve assembly includes a coupler-aspirator having two flow passages joining in a nozzle. Each flow passage communicates with a chamber. One of the chambers houses a valve stem which couples to a valveless propellant cartridge. The other of the chambers houses a product container valve stem which couples to a valveless product container assembly.

Process for producing hardenable epoxy resin compositions

Abstract: A PROCESS FOR PRODUCING EPOXIDE COMPOSITIONS USEFUL IN A VARIETYOF APPLICATIONS ESPECIALLY IN COMPRESSION MOLDING IS DISCLOSED. A LOW-BOILING SINGLE OR FORMULATED SOLVENT IS USED TO DISSOLVE THE APPROPRIATE RESIN AND A CURING AGENT THEREFOR AND SAID SOLUTION USED TO COAT OR IMPREGNATE A SUITABLE REINFORCEMENT MATERIAL, PREFERABLY A CONTINUOUS ROVING TYPE. THE SOLVENT IS THEN DRIVEN OFF UNDER CONDITIONS WHCH BY VIRTUE OF THE NATURE OF THE SOLVENT PERMIT SOLVENT EVAPORATION WITHOUT A SUBSTANTIAL PRECURING OF EPOXY RESIN.

Process for the recovery of hydrophilic antibiotics

Abstract: The isolation of cephalosporin C from solutions containing it in admixture with impurities stemming from the fermentation broth by adsorption on macroporous, non-ionic adsorption resins with large surface.

Method and apparatus for coding messages

Abstract: A method and apparatus for coding messages is provided comprising coding the clear information by an encoding program generated by a secret basic code and modified by selected parts of a non-secret supplementary code, the coded information be recorded together with the whole of the supplementary code on a common record medium. The selection of parts of the supplementary code is controlled by the secret basic code.

2-amino-4-aryl-quinolines

Abstract: 2-Amino-4-aryl-quinolines, e.g. those of the formula ACYL DERIVATIVES, QUATERNARIES AND SALTS THEREOF, EXHIBIT ANTIINFLAMMATORY EFFECTS.

Multi-component dispenser and valve

Abstract: A dispenser includes a container enclosing several fluid components in isolated sac chambers. The chambers communicate through a valve with at least one passage in a coupler-aspirator. An aerosol propellant cartridge with a valve couples with another passage in the coupler-aspirator. The valve includes a stationary stem and a movable stem member. The sac chambers have adaptors which communicate with the valve. The adaptors may be unitary or individual.

Self-sealing and locking collar and container

Abstract: A container having an annular neck is sealed liquid tight to a cap having two annular flanges. The neck fits between the two flanges, the inner surface of the neck creating a seal with the outer surface of the inner flange, and the outer diameter of the neck having an annular bead which creates a seal with the inner surface of the outer flange. The thickness of the neck at the bead is greater than the space between the flanges. The outer diameter of the inner flange is greater than the inner diameter of the neck. The cap and container may be made of dissimilar plastic materials. The cap may snap or screw onto the container. Locking means may be provided to prevent removal of the cap from the container.

Air pressure operated dispenser

Abstract: A dispensing device in which the product to be dispensed is aspirated and sprayed by the discharged pressurized air. A valve assembly has a product flow path therethrough and a compressed air flow path therethrough. The valve stem of the assembly is actuated to open the flow paths, and aspirating means is provided at the upper end of said stem for bringing one end of each of said flow paths together. A piston-cylinder assembly is provided on the device having a cylinder with one end around the end of the compressed air flow path, a piston slidable in the cylinder, and a piston rod on said piston and extending out of the other end of said cylinder. A product containing sac has a neck thereon sealed around the end of the product flow path. An actuator means is connected between the piston rod and the valve assembly for moving the valve stem relative to the valve body for opening the flow paths when the piston is moved to the inner end of the cylinder adjacent the valve assembly to provide a predetermined amount of compressed air.