Nuffield Orthopaedic Centre

About: Nuffield Orthopaedic Centre is a healthcare organization based out in Oxford, United Kingdom. It is known for research contribution in the topics: Population & Arthroplasty. The organization has 2082 authors who have published 2920 publications receiving 145718 citations.

Total knee arthroplasty fixation comparison of the early results of paired cemented versus uncemented porous coated anatomic knee prostheses

Abstract: The results of 18 matched pairs of Porous Coated Anatomic knee prostheses were studied to compare the early clinical and functional performance of cemented versus uncemented fixation with an average five-year follow-up period for both. The knee score improved from a preoperative average of 35 points to a postoperative average of 90 points in the cemented group, and from 38 points to 93 points in the uncemented group. In particular, the individual pain scores and the range-of-motion values were well matched at the three-, six-, and 12-month follow-up visits and showed a steady improvement. Subjectively, all patients were pleased with the results of surgery; one-third preferred the cemented side, one-third preferred the uncemented side, and one-third found no difference in the performance of either knee. The clinical and functional performance of knee prostheses in patients who had one cemented knee and one uncemented knee were comparable and possibly unrelated to the type of fixation method.

Measuring Limb Volume: Accuracy and Reliability of Tape Measurement Versus Perometer Measurement

Abstract: Background: Accurate limb volume measurement is key in the assessment of outcomes in lymphedema microsurgery. There are two commonly used methods as follows: manual circumferential measure...

Expression of BMP-4 mRNA during distraction osteogenesis in rabbits

Abstract: We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.

Risks and benefits of prophylaxis against venous thromboembolism in orthopaedic surgery

Abstract: W. Gillespie, DeanDunedin School of Medicine, PO Box 913, Dunedin, New Zealand.D. Murray, MD, FRCS, FRCS (Orth), Professor of Orthopaedic SurgeryNuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX37LD, UK.P. J. Gregg, MD, FRCS, Professor of Orthopaedic SurgeryThe Medical School, University of Newcastle upon Tyne, Newcastle uponTyne NE2 4HH, UK.D. Warwick, MD, FRCS, FRCS (Orth), Consultant Orthopaedic SurgeonSouthampton University Hospitals NHS Trust, Tremona Road, South-ampton SO16 6YD, UK.Correspondence should be sent to W. Gillespie©2000 British Editorial Society of Bone and Joint Surgery0301-620X/00/410452 $2.00

ISIS scanning: a useful assessment technique in the management of scoliosis.

Abstract: The value of surface topographical measurements in the assessment of curve progression in adolescent idiopathic scoliosis is demonstrated in a group of 51 patients. Cobb angles at the commencement of the study ranged from 10 degrees -55 degrees (mean 34.5 degrees), and the mean follow-up period was greater than 2 years. The surface shape method correctly identified curve evolution in 84% of the patient group. Of these, the eight patients who underwent spinal instrumentation were correctly predicted as candidates for surgery.