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Showing papers by "Ocean University of China published in 1998"


Journal ArticleDOI
TL;DR: The results strongly suggest that taurine Schiff base copper complexes, as potent proteasome inhibitors, have great potential to be developed into novel anticancer drugs.
Abstract: Schiff bases have been intensively investigated due to their antibacterial and antitumor properties. Copper is a cofactor essential for the tumor angiogenesis processes, whereas other transition metals are not. Consistently, high serum or tissue levels of copper were found in many types of human cancer including breast, prostate, colon, lung, and brain, supporting the idea that copper could be used as a novel selective target for cancer therapies. In the current study we hypothesize that a synthetic taurine Schiff base copper complex (Compound 1) could suppress tumor cell growth via the direct inhibition of proteasomal activity. Compound 1 potently inhibits the activity of purified 20S and 26S proteasome in human breast cancer MDA-MB-231 and leukemia Jurkat T cells. Inhibition of tumor cellular proteasomal activity by Compound 1 results in the accumulation of ubiquitinated protein and the proteasome target proteins p27 and Bax, followed by the induction of apoptosis. Our results strongly suggest that taurine Schiff base copper complexes, as potent proteasome inhibitors, have great potential to be developed into novel anticancer drugs.

46 citations


Journal ArticleDOI
TL;DR: A simple and sensitive fluorimetric method for the determination of epinephrine is described in this paper, which is based on the reaction of Epinephrine with o-phenylenediamine in alkaline medium and the addition of 0.2% (v/v) acetone enhances the fluorescence 50-fold.

45 citations



Journal ArticleDOI
TL;DR: A fluorescence method for the selective determination of DNA in the presence of RNA was developed and revealed that double-stranded DNA can enhance remarkably the fluorescence intensity of THAQ-Be2+, while RNA cannot.

22 citations


Journal Article
Liu S1, Su K
TL;DR: This paper described a HPLC method for determining dimethyl fumarate (DMF), a new antimicrobial preservative, and the sample size and peak area showed a linear relationship with regression equation.

11 citations


Journal ArticleDOI
TL;DR: In this paper, a cross-flow ultrafiltration technique was used to separate colloidal organic carbon (COC) from natural water, and COC in three water samples that were collected from Huanghe, Changjiang and Qiantang River was determined.
Abstract: Cross-flow ultrafiltration techniques havc been used to separate colloidal organic carbon (COC) from natural water, and COC in three water samples that were collected from Huanghe, Changjiang and Qiantang River was determined. On average, COC comprised about 68.6% of the total dissolved organic carbon. The abundance of COC suggested that COC could play important roles in input fluxes and biogeochemistry of organic carbon.

3 citations