Institution
Ocean University of China
Education•Qingdao, China•
About: Ocean University of China is a education organization based out in Qingdao, China. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 27604 authors who have published 27886 publications receiving 440181 citations. The organization is also known as: Zhōngguó Hǎiyáng Dàxué & OUC.
Topics: Population, Sea surface temperature, Gene, Chemistry, Adsorption
Papers published on a yearly basis
Papers
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TL;DR: Practical, the manipulation of maternal immunity transfer can be used to enhance the survival rate of fish larvae, and the mode of action of complement components and yolk proteins has been explored, whereas that of all the other factors remains elusive.
Abstract: Both innate and adaptive immune-relevant factors are transferred from mother to offspring in fishes. These maternally-transferred factors include IgM, lysozymes, lectin, cathelicidin and complement components. Recently, yolk proteins, phosvitin and lipovitellin, have been shown to be maternally-transferred factors, functioning in the defense of teleost larvae against pathogens. Among these factors, the mode of action of complement components and yolk proteins has been explored, whereas that of all the other factors remains elusive. At present, the transfer mechanisms of maternally-derived immune factors are largely unknown although those of IgM and yolk protein transmission from mother to offspring have been reported in some fishes. Maternal transfer of immunity is affected by many elements, including biological factors, such as age and maturation, and environmental conditions experienced by brood fish, such as pathogens and nutritional supply. Practically, the manipulation of maternal immunity transfer can be used to enhance the survival rate of fish larvae.
108 citations
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TL;DR: This study provides strong evidence that the cellular proteasome is an important target of both gold(I) and gold(III)–dithiocarbamates, but distinct cellular mechanisms of action are responsible for their different overall effect.
Abstract: We have previously reported on a gold(III) complex, namely [AuBr(2)(DMDT)] (N,N-dimethyldithiocarbamate) showing potent in vitro and in vivo growth inhibitory activities toward human cancer cells and identifying the cellular proteasome as one of the major targets. However, the importance of the oxidation state of the gold center and the involved mechanism of action has yet to be established. Here we show that both gold(III)- and gold(I)-dithiocarbamato species, namely [AuBr(2)(ESDT)] (AUL12) and [Au(ESDT)](2) (AUL15), could inhibit the chymotrypsin-like activity of purified 20S proteasome and 26S proteasome in human breast cancer MDA-MB-231 cells, resulting in accumulation of ubiquitinated proteins and proteasome target proteins, and induction of cell death, but at significantly different levels. Gold(I)- and gold(III)-compound-mediated proteasome inhibition and cell death induction were completely reversed by the addition of a reducing agent, dithiothreitol or N-acetyl-L-cysteine, suggesting the involvement of redox processes. Furthermore, treatment of MDA-MB-231 cells with gold(III) compound (AUL12), but not the gold(I) analog (AUL15), resulted in the production of significant levels of reactive oxygen species. Our study provides strong evidence that the cellular proteasome is an important target of both gold(I) and gold(III)-dithiocarbamates, but distinct cellular mechanisms of action are responsible for their different overall effect.
108 citations
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TL;DR: It was shown that fucoidan intervention could relieve injury such as decreasing inflammation and increasing the expression of tight junction proteins, and 50 kDa fu coidan significantly increased the abundance of short chain fatty acid (SCFA) producer Coprococcus, Rikenella, and Butyricicoccus species within the intestinal mucosa.
Abstract: Cyclophosphamide (cy) is a widely used cancer drug. Many researchers have focused on the prevention and alleviation of its side effects, particularly damage to the intestinal mucosal barrier. In this study, we examined the effects of fucoidan, isolated from Acaudina molpadioides, on mice with intestinal mucosal damage induced by cyclophosphamide. Our results showed that fucoidan intervention could relieve injury such as decreasing inflammation and increasing the expression of tight junction proteins, and 50 kDa fucoidan significantly increased the abundance of short chain fatty acid (SCFA) producer Coprococcus, Rikenella, and Butyricicoccus (p < 0.05, p < 0.001, and p < 0.05, respectively) species within the intestinal mucosa compared with the cyclophosphamide group, as determined by 16S rDNA gene high-throughput sequencing. In addition, SCFAs, particularly propionate, butyrate, and total SCFAs, were increased in the feces, and SCFA receptors were upregulated in the small intestine. The protective effects of fucoidan on cyclophosphamide treatment may be associated with gut microflora, and 50 kDa fucoidan had superior effects. Therefore, fucoidan may have applications as an effective supplement to protect against intestinal mucosal barrier damage during chemotherapy.
108 citations
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TL;DR: Microbial activities and microbial abundance in HSFCW4 was found to be influenced by DO distribution and step-feeding, and thus improve TN removal, suggesting that artificial aeration combined with step- feeding could achieve high nitrogen removal in HS FCWs.
108 citations
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TL;DR: In this paper, Lactobacillus casei ATCC 393 was encapsulated with alginate, chitosan and carboxymethyl CHITosan by extrusion method and the product could increase the cell numbers of L. casei to be 108cfu/g in the dry state after storage at 4°C for 4 weeks.
108 citations
Authors
Showing all 27836 results
Name | H-index | Papers | Citations |
---|---|---|---|
Guangming Zeng | 146 | 1676 | 100743 |
Bin Wang | 126 | 2226 | 74364 |
Simon A. Wilde | 118 | 390 | 45547 |
Yusuke Yamauchi | 117 | 1000 | 51685 |
Xiaoming Li | 113 | 1932 | 72445 |
Baoshan Xing | 109 | 823 | 48944 |
Peng Wang | 108 | 1672 | 54529 |
Jun Yang | 107 | 2090 | 55257 |
Shang-Ping Xie | 105 | 441 | 36437 |
M. Santosh | 103 | 1344 | 49846 |
Qi Li | 102 | 1563 | 46762 |
Wei Liu | 102 | 2927 | 65228 |
Tao Wang | 97 | 2720 | 55280 |
Wei Wang | 95 | 3544 | 59660 |
Peng Li | 95 | 1548 | 45198 |