Ocean University of China

About: Ocean University of China is a education organization based out in Qingdao, China. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 27604 authors who have published 27886 publications receiving 440181 citations. The organization is also known as: Zhōngguó Hǎiyáng Dàxué & OUC.

Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease.

Abstract: Recent findings that human serum contains stably expressed microRNAs (miRNAs) have revealed a great potential of serum miRNA signature as disease fingerprints to diagnosis. Here we used genome-wide serum miRNA expression analysis to investigate the value of serum miRNAs as biomarkers for the diagnosis of Alzheimer's disease (AD). Illumina HiSeq 2000 sequencing followed by individual quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assays was used to test the difference in levels of serum miRNAs between 50 AD patients and 50 controls in the screening stages. The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. MiR-98-5p, miR-885-5p, miR-483-3p, miR-342-3p, miR-191-5p, and miR-let-7d-5p displayed significantly different expression levels in AD patients compared with controls. Among the 6 miRNAs, miR-342-3p has the best sensitivity (81.5%) and specificity (70.1%) and was correlated to Mini-Mental State Examination score. This study identified six serum miRNAs that distinguish AD patients from healthy controls with high sensitivity and specificity. Serum miRNA panel (or miR-342-3p alone) may serve as a novel, noninvasive biomarker for AD.

Mesozoic, Not Paleoproterozoic SHRIMP U-Pb Zircon Ages of Two Liaoji Granites, Eastern Block, North China Craton

Abstract: The Paleoproterozoic Jiao-Liao-Ji orogen in the North China craton is composed mainly of the Liaohe Group (and its equivalents) and the Liaoji Granites. The latter have long been considered to be Paleoproterozoic in age, but have not been precisely constrained by reliable isotopic ages. CL and BSE images reveal the existence of both magmatic and xenocrystal/inherited zircons in one rock sample each from the Dandong and Gaoliduntai granites, two major Liaoji Granite intrusions. The magmatic zircons occur as either single grains or rims surrounding or truncating xenocrystal/inherited zircon cores, and are characterized by euhedral, prismatic grains with well-developed oscillatory zoning, whereas the xenocrystal/inherited zircons occur either as cores surrounded by the igneous zircon rims, or as single grains exhibiting weakly zoned bands. The magmatic zircons yielded ages of 157.4 ± 5.7 Ma and 156.3 ± 4.8 Ma for the Dandong and Gaoliduntai granites, respectively, indicating that these two plutons were empla...