Ochsner Medical Center

About: Ochsner Medical Center is a healthcare organization based out in New Orleans, Louisiana, United States. It is known for research contribution in the topics: Population & Heart failure. The organization has 980 authors who have published 1159 publications receiving 49961 citations. The organization is also known as: Ochsner Hospital & Ochsner Foundation Hospital.

Multiagent neoadjuvant chemotherapy and tumor response are associated with improved survival in pancreatic cancer.

Abstract: Background Neoadjuvant therapy (NT) for borderline resectable pancreatic cancer (BRPC) has evolved to include multi-agent regimens and chemoradiation. We report our experience and compare outcomes of initially resectable pancreatic cancer (IRPC) vs BRPC receiving NT across two eras of chemotherapy regimens. Methods Data were collected retrospectively on pancreaticoduodenectomy patients between January 2008 and October 2015. Outcomes and survival were compared based on patient, laboratory and treatment factors. Results 195 patients were included and 133 had IRPC and 62 BRPC. IRPC operations were shorter (449 min vs 520 min, p = 0.003), had less blood loss (663 ml vs 954 ml, p = 0.002) and involved fewer vascular resections (29% vs 76%, p = 0.002). The rate of R0 resection was identical (82%, p = 1) and the IRPC group had higher node-positive ratio (19.3% vs 7.2% p Conclusions BRPC patients treated with NT have similar morbidity and survival to their IRPC counterparts. Pathologic response and modern NT are associated with improved survival.

Physostigmine in tricyclic antidepressant overdose

Abstract: Acute accidental and suicidal overdosages are becoming common in emergency medicine Physostigmine salicylate (Antilirium) is the only parasympathomimetic drug capable of reversing both the central and peripheral manifestations of the anticholinergic syndrome caused by overdosage of tricyclic antidepressant drugs Physostigmine acts rapidly, within 5 to 20 minutes, dramatically reversing the toxic effects Because of the short duration of action, intoxication may recur and repeated doses may be necessary Four cases, successfully managed, are presented and the pertinent literature reviewed

Lanreotide vs octreotide LAR for patients with advanced gastroenteropancreatic neuroendocrine tumors: An observational time and motion analysis.

Abstract: BackgroundLanreotide and octreotide acetate suspension for injectable (LAR) are both recommended for clinical use in patients with locally advanced or metastatic gastroenteropancreatic neuroendocri...