Ochsner Medical Center

About: Ochsner Medical Center is a healthcare organization based out in New Orleans, Louisiana, United States. It is known for research contribution in the topics: Population & Heart failure. The organization has 980 authors who have published 1159 publications receiving 49961 citations. The organization is also known as: Ochsner Hospital & Ochsner Foundation Hospital.

Imaging Modalities for Evaluation of Intestinal Obstruction.

Abstract: It is essential for the colon and rectal surgeon to understand the evaluation and management of patients with both small and large bowel obstructions. Computed tomography is usually the most appropriate and accurate diagnostic imaging modality for most suspected bowel obstructions. Additional commonly used imaging modalities include plain radiographs and contrast imaging/fluoroscopy, while less commonly utilized imaging modalities include ultrasonography and magnetic resonance imaging. Regardless of the imaging modality used, interpretation of imaging should involve a systematic, methodological approach to ensure diagnostic accuracy.

A de novo deletion of CALN1 in a male with a bilateral diaphragmatic defect does not definitely cause this malformation

Abstract: A De Novo Deletion of CALN1 in a Male With a Bilateral Diaphragmatic Defect Does Not Definitely Cause This Malformation Anne M. Slavotinek,* Jill A. Rosenfeld, Ryan Chao, Dimitry Niyazov, Marthand Eswara, Patricia I. Bader, David W. Stockton, Pawel Stankiewicz, and Margaret P. Adam Division of Genetics, Department of Pediatrics, University of California, San Francisco, San Francisco, California Signature Genomic Laboratories, Spokane, Washington Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington Department of Pediatrics, Ochsner Clinic Foundation, New Orleans, Louisiana Pediatric Genetics & Metabolic Disorders Service, Sutter Medical Center, Sacramento, California Northeast Indiana Genetic Counseling Center, Parkview Health Systems, Wayne, Indiana Division of Genetic and Metabolic Disorders, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas Division of Genetic Medicine, Department of Pediatrics, Seattle Children’s Hospital, Seattle, Washington

Achieving antihyperglycemic treatment goals with incretin-related therapies.

Abstract: The management of type 2 diabetes mellitus (T2DM) remains challenging. Limitations associated with many current therapies include hypoglycemia and weight gain. An increased understanding of the pathophysiology of T2DM has led to the development of incretin-related antihyperglycemic therapies. These agents enhance insulin secretion and inhibit inappropriate glucagon secretion, both in a glucose-dependent manner. As a result, they can lower blood glucose levels with a low risk of hypoglycemia or weight gain. Incretin-based therapies, the dipeptidyl peptidase 4 inhibitors and the glucagonlike peptide-1 receptor agonists, are now integrated into T2DM treatment algorithms. Trial data and clinical experience have shown that these agents are efficacious and generally well tolerated.

Neuroendocrinology of the Hypothalamus and Pituitary Axes

Abstract: The hypothalamus and pituitary gland which are, respectively, the approximate sizes of an almond and a bean seed form an integral part of the interface between the endocrine system and the central nervous system. The hypothalamus in addition is central in coordinating various metabolic, autonomic, and behavioral responses to environmental stimuli. These effects are mediated to less degree by neuronal connections with the rest of the brain and more so via the synthesis and secretion of myriad neurohormones which include stimulatory (releasing) and inhibitory hormones. These hormones and the secondary humoral factors whose secretion they modulate have central roles in the homeostatic control of processes as diverse as hunger, appetite, energy balance, temperature control, sleep regulation, other circadian rhythms, reproductive function, and social behavioral activities including affection and aggression. This chapter highlights the neuroendocrine functional relationships of the hypothalamic and pituitary axes to the rest of human systemic function.