Ochsner Medical Center

About: Ochsner Medical Center is a healthcare organization based out in New Orleans, Louisiana, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 980 authors who have published 1159 publications receiving 49961 citations. The organization is also known as: Ochsner Hospital & Ochsner Foundation Hospital.

Donation After Cardiac Death

Abstract: The gap between the number of patients on the waiting list and the number of organs available for transplant is continuing to widen. Along with exploring living donation, donation after cardiac death (DCD) presents an excellent source of organs and adds to the supply of organs available for transplant. Results have shown that kidneys and pancreata from DCD donors do equally well in the long term. The results for livers from DCD donors have a higher rate of complications, but nonetheless, have acceptable results in terms of patient and graft survival.

Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia

Abstract: The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies.

Endoscopic Retrieval of Foreign Bodies

Abstract: Endoscopic retrieval of gastrointestinal foreign bodies is a commonly performed procedure among surgeons and gastroenterologists. Most true foreign body ingestions occur in young children 6 months to 6 years of age. Particular occupations, psychiatric diseases, and incarceration pose unique risks for foreign body ingestion. Food impaction occurs more commonly in adults, and is generally associated with underlying esophageal pathology. Colorectal foreign bodies most frequently occur during erotic stimulation, and may result in delayed presentation and incomplete histories due to embarrassment. Flexible endoscopy is the most efficacious approach to foreign body retrieval, with success rates greater than 95% and low procedure-related complications. Timely intervention reduces the risks of foreign body-related complications, such as complete obstruction, perforation, fistulization, or abscess formation.