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Institution

Ohio State University

EducationColumbus, Ohio, United States
About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.


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22 Apr 1999
TL;DR: The design approach based on the regularization is generalized for mechanical systems and it is shown that stability of zero dynamics should be taken into account when the regular form consists of blocks of second-order equations.
Abstract: Introduction Examples of Dynamic Systems with Sliding Modes Sliding Modes in Relay and Variable Structure Systems Multidimensional Sliding Modes Outline of Sliding Mode Control Methodology Mathematical Background Problem Statement Regularization Equivalent Control Method Physical Meaning of Equivalent Control Existence Conditions Design Concepts Introductory Example Decoupling Regular Form Invariance Unit Control Second-Order Sliding Mode Control Sliding Mode Control of Pendulum Systems Design Methodology Cart Pendulum Rotational Inverted Pendulum (Model) Rotational Inverted Pendulum (Control) Simulation and Experiment Results for Rotational Inverted Pendulum Control of Linear Systems Eigenvalue Placement Invariant Systems Sliding Mode Dynamic Compensators Ackermanns Formula Output Feedback Sliding Mode Control Control of Time-Varying Systems Sliding Mode Observers Linear Asymptotic Observers Observers for Linear Time-Invariant Systems Observers for Linear Time-Varying Systems Observer for Linear Systems with Binary Output Integral Sliding Mode Motivation Problem Statement Design Principles Perturbation and Uncertainty Estimation Examples Summary The Chattering Problem Problem Analysis Boundary Layer Solution Observer-Based Solution Regular Form Solution Disturbance Rejection Solution State-Dependent Gain Method Equivalent Control-Dependent Gain Method Multiphase Chattering Suppression Comparing the Different Solutions Discrete-Time and Delay Systems Introduction to Discrete-Time Systems Discrete-Time Sliding Mode Concept Linear Discrete-Time Systems with Known Parameters Linear Discrete-Time Systems with Unknown Parameters Introduction to Systems with Delays and Distributed Systems Linear Systems with Delays Distributed Systems Summary Electric Drives DC Motors Permanent-Magnet Synchronous Motors Induction Motors Summary Power Converters DC/DC Converters Boost-Type AC/DC Converters DC/AC Converter Summary Advanced Robotics Dynamic Modeling Trajectory Tracking Control Gradient Tracking Control Application Examples Automotive Applications Air/Fuel Ratio Control Camless Combustion Engine Observer for Automotive Alternator

904 citations

Journal ArticleDOI
TL;DR: Critical issues that must be addressed include the need for more selective and effective boron delivery agents, the development of methods to provide semiquantitative estimates of tumor borons content before treatment, improvements in clinical implementation of BNCT, and a need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy.
Abstract: Background: Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield high linear energy transfer α particles and recoiling lithium-7 nuclei. Clinical interest in BNCT has focused primarily on the treatment of high-grade gliomas and either cutaneous primaries or cerebral metastases of melanoma, most recently, head and neck and liver cancer. Neutron sources for BNCT currently are limited to nuclear reactors and these are available in the United States, Japan, several European countries, and Argentina. Accelerators also can be used to produce epithermal neutrons and these are being developed in several countries, but none are currently being used for BNCT. Boron Delivery Agents: Two boron drugs have been used clinically, sodium borocaptate (Na 2 B 12 H 11 SH) and a dihydroxyboryl derivative of phenylalanine called boronophenylalanine. The major challenge in the development of boron delivery agents has been the requirement for selective tumor targeting to achieve boron concentrations (∼20 μg/g tumor) sufficient to deliver therapeutic doses of radiation to the tumor with minimal normal tissue toxicity. Over the past 20 years, other classes of boron-containing compounds have been designed and synthesized that include boron-containing amino acids, biochemical precursors of nucleic acids, DNA-binding molecules, and porphyrin derivatives. High molecular weight delivery agents include monoclonal antibodies and their fragments, which can recognize a tumor-associated epitope, such as epidermal growth factor, and liposomes. However, it is unlikely that any single agent will target all or even most of the tumor cells, and most likely, combinations of agents will be required and their delivery will have to be optimized. Clinical Trials: Current or recently completed clinical trials have been carried out in Japan, Europe, and the United States. The vast majority of patients have had high-grade gliomas. Treatment has consisted first of “debulking” surgery to remove as much of the tumor as possible, followed by BNCT at varying times after surgery. Sodium borocaptate and boronophenylalanine administered i.v. have been used as the boron delivery agents. The best survival data from these studies are at least comparable with those obtained by current standard therapy for glioblastoma multiforme, and the safety of the procedure has been established. Conclusions: Critical issues that must be addressed include the need for more selective and effective boron delivery agents, the development of methods to provide semiquantitative estimates of tumor boron content before treatment, improvements in clinical implementation of BNCT, and a need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy. If these issues are adequately addressed, then BNCT could move forward as a treatment modality.

904 citations

Journal ArticleDOI
TL;DR: The state factor approach is used to highlight the role of important aspects of climate, substrate, organisms, relief, and time in differentiating urban from non-urban areas, and for determining heterogeneity within spatially extensive metropolitan areas.

903 citations

Journal ArticleDOI
TL;DR: This study randomly assigned women with node-positive or high-risk node-negative breast cancer who were treated with breast-conserving surgery and adjuvant systemic therapy to undergo whole-breast irradiation plus regional nodal irradiation (including internal mammary, supraclavicular, and axillary lymph nodes).
Abstract: BackgroundMost women with breast cancer who undergo breast-conserving surgery receive whole-breast irradiation. We examined whether the addition of regional nodal irradiation to whole-breast irradiation improved outcomes. MethodsWe randomly assigned women with node-positive or high-risk node-negative breast cancer who were treated with breast-conserving surgery and adjuvant systemic therapy to undergo either whole-breast irradiation plus regional nodal irradiation (including internal mammary, supraclavicular, and axillary lymph nodes) (nodal-irradiation group) or whole-breast irradiation alone (control group). The primary outcome was overall survival. Secondary outcomes were disease-free survival, isolated locoregional disease-free survival, and distant disease-free survival. ResultsBetween March 2000 and February 2007, a total of 1832 women were assigned to the nodal-irradiation group or the control group (916 women in each group). The median follow-up was 9.5 years. At the 10-year follow-up, there was n...

903 citations

Journal ArticleDOI
TL;DR: In this article, a new gas-grain chemical network was introduced, where a wide array of complex species may be formed by reactions involving radicals, and several of these species were detected in hot cores.
Abstract: Gas-phase processes were long thought to be the key formation mechanisms for complex organic molecules in star-forming regions. However, recent experimental and theoretical evidence has cast doubt on the efficiency of such processes. Grain-surface chemistry is frequently invoked as a solution, but until now there have been no quantitative models taking into account both the high degree of chemical complexity and the evolving physical conditions of star-forming regions. Here, we introduce a new gas-grain chemical network, wherein a wide array of complex species may be formed by reactions involving radicals. The radicals we consider (H, OH, CO, HCO, CH3, CH3O, CH2OH, NH, and NH2) are produced primarily by cosmic ray-induced photodissociation of the granular ices formed during the colder, earlier stages of evolution. The gradual warm up of the hot core is crucial to the formation of complex molecules, allowing the more strongly bound radicals to become mobile on grain surfaces. This type of chemistry is capable of reproducing the high degree of complexity seen in Sgr B2(N), and can explain the observed abundances and temperatures of a variety of previously detected complex organic molecules, including structural isomers. Many other complex species are predicted by this model, and several of these species may be detectable in hot cores. Differences in the chemistry of high- and low-mass star formation are also addressed; greater chemical complexity is expected where evolution timescales are longer.

902 citations


Authors

Showing all 103197 results

NameH-indexPapersCitations
Paul M. Ridker2331242245097
George Davey Smith2242540248373
Carlo M. Croce1981135189007
Eric J. Topol1931373151025
Bernard Rosner1901162147661
David H. Weinberg183700171424
Anil K. Jain1831016192151
Michael I. Jordan1761016216204
Kay-Tee Khaw1741389138782
Richard K. Wilson173463260000
Yang Yang1642704144071
Brian L Winer1621832128850
Jian-Kang Zhu161550105551
Elaine R. Mardis156485226700
R. E. Hughes1541312110970
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023261
20221,234
20219,945
20209,944
20199,052
20188,656