Institution
Ohio State University
Education•Columbus, Ohio, United States•
About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.
Topics: Population, Poison control, Galaxy, Cancer, Breast cancer
Papers published on a yearly basis
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TL;DR: It is proposed that there are alternative tumour-promoting activities for the E2F family, which are independent of cell cycle regulation.
Abstract: Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating the RB pathway have been identified in almost every human malignancy. The E2F transcription factors function in cell cycle control and are intimately regulated by RB. Studies of model organisms have revealed conserved functions for E2Fs during development, suggesting that the cancer-related proliferative roles of E2F family members represent a recent evolutionary adaptation. However, given that some human tumours have concurrent RB1 inactivation and E2F amplification and overexpression, we propose that there are alternative tumour-promoting activities for the E2F family, which are independent of cell cycle regulation.
855 citations
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TL;DR: In this article, the authors explore the relationship among experience, environment, and performance at the subsidiary level and find that the intensity and diversity of host country experience is an important predictor of subunit performance.
Abstract: Does organizational learning as measured by experience in a host country affect international expansion performance? If so, does such a relationship between experience and performance hold over time? How do the environmental forces in the host country affect such a relationship? Focusing on organizational learning by multinational enterprises (MNEs) operating in a transition economy, this study answers these three critical questions by exploring the relationships among experience, environment, and performance at the subsidiary level. Based on a recent survey of 108 MNE subunits operating in China, we find that the intensity and diversity of host country experience is an important predictor of subunit performance. While the positive effect of the intensity of experience on performance diminishes over time, the impact of the diversity of experience on performance remains unchanged. Moreover, for MNEs experiencing greater environmental dynamism, complexity, and hostility, there is a stronger positive relationship between experience and performance.
855 citations
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TL;DR: The authors of as mentioned in this paper showed that approximately 30%-40% of all baryons in the present-day universe reside in a warm-hot intergalactic medium (WHIM), with temperatures in the range 105 < T < 107 K. This is a generic prediction from six hydrodynamic simulations of currently favored structure formation models having a wide variety of numerical methods, input physics, volumes, and spatial resolutions.
Abstract: Approximately 30%-40% of all baryons in the present-day universe reside in a warm-hot intergalactic medium (WHIM), with temperatures in the range 105 < T < 107 K. This is a generic prediction from six hydrodynamic simulations of currently favored structure formation models having a wide variety of numerical methods, input physics, volumes, and spatial resolutions. Most of these warm-hot baryons reside in diffuse large-scale structures with a median overdensity around 10-30, not in virialized objects such as galaxy groups or galactic halos. The evolution of the WHIM is primarily driven by shock heating from gravitational perturbations breaking on mildly nonlinear, nonequilibrium structures such as filaments. Supernova feedback energy and radiative cooling play lesser roles in its evolution. WHIM gas may be consistent with observations of the 0.25 keV X-ray background without being significantly heated by nongravitational processes because the emitting gas is very diffuse. Our results confirm and extend previous work by Cen & Ostriker and Dave et al.
854 citations
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Institute of Arctic and Alpine Research1, Stony Brook University2, University of Gothenburg3, Marine Biological Laboratory4, University of Alberta5, University of Basel6, University of Zurich7, University of British Columbia8, Ohio State University9, Michigan State University10, University of Oulu11, Université du Québec à Trois-Rivières12, Cold Regions Research and Engineering Laboratory13, Komarov Botanical Institute14, King's College London15, Florida International University16, University of Bergen17, University of Wyoming18, University of London19
TL;DR: Results indicate that key phenological events such as leaf bud burst and flowering occurred earlier in warmed plots throughout the study period; however, there was little impact on growth cessation at the end of the season.
Abstract: The International Tundra Experiment (ITEX) is a collaborative, multisite experiment using a common temperature manipulation to examine variability in species response across climatic and geographic gradients of tundra ecosystems. ITEX was designed specifically to examine variability in arctic and alpine species response to increased temperature. We compiled from one to four years of experimental data from 13 different ITEX sites and used meta-analysis to analyze responses of plant phenology, growth, and reproduction to experimental warming. Results indicate that key phenological events such as leaf bud burst and flowering occurred earlier in warmed plots throughout the study period; however, there was little impact on growth cessation at the end of the season. Quantitative measures of vegetative growth were greatest in warmed plots in the early years of the experiment, whereas reproductive effort and success increased in later years. A shift away from vegetative growth and toward reproductive effort and success in the fourth treatment year suggests a shift from the initial response to a secondary response. The change in vegetative response may be due to depletion of stored plant reserves, whereas the lag in reproductive response may be due to the formation of flower buds one to several seasons prior to flowering. Both vegetative and reproductive responses varied among life-forms; herbaceous forms had stronger and more consistent vegetative growth responses than did woody forms. The greater responsiveness of the herbaceous forms may be attributed to their more flexible morphology and to their relatively greater proportion of stored plant reserves. Finally, warmer, low arctic sites produced the strongest growth responses, but colder sites produced a greater reproductive response. Greater resource investment in vegetative growth may be a conservative strategy in the Low Arctic, where there is more competition for light, nutrients, or water, and there may be little opportunity for successful germination or seedling development. In contrast, in the High Arctic, heavy investment in producing seed under a higher temperature scenario may provide an opportunity for species to colonize patches of unvegetated ground. The observed differential response to warming suggests that the primary forces driving the response vary across climatic zones, functional groups, and through time.
854 citations
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TL;DR: The role of AR in androgen-independent cancer cells is not to direct the androgen -dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgens-independent growth.
853 citations
Authors
Showing all 103197 results
Name | H-index | Papers | Citations |
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Paul M. Ridker | 233 | 1242 | 245097 |
George Davey Smith | 224 | 2540 | 248373 |
Carlo M. Croce | 198 | 1135 | 189007 |
Eric J. Topol | 193 | 1373 | 151025 |
Bernard Rosner | 190 | 1162 | 147661 |
David H. Weinberg | 183 | 700 | 171424 |
Anil K. Jain | 183 | 1016 | 192151 |
Michael I. Jordan | 176 | 1016 | 216204 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Richard K. Wilson | 173 | 463 | 260000 |
Yang Yang | 164 | 2704 | 144071 |
Brian L Winer | 162 | 1832 | 128850 |
Jian-Kang Zhu | 161 | 550 | 105551 |
Elaine R. Mardis | 156 | 485 | 226700 |
R. E. Hughes | 154 | 1312 | 110970 |