Ohio State University

About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.

Daily cost of an intensive care unit day: the contribution of mechanical ventilation.

Abstract: Objective:To quantify the mean daily cost of intensive care, identify key factors associated with increased cost, and determine the incremental cost of mechanical ventilation during a day in the intensive care unit.Design:Retrospective cohort analysis using data from NDCHealth’s Hospital Patient Lev

MiR-15a and miR-16-1 cluster functions in human leukemia.

Abstract: MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles in human diseases, including cancer. Each miRNA is predicted to regulate hundreds of transcripts, but only few have experimental validation. In chronic lymphocytic leukemia (CLL), the most common adult human leukemia, miR-15a and miR-16-1 are lost or down-regulated in the majority of cases. After our previous work indicating a tumor suppressor function of miR-15a/16-1 by targeting the BCL2 oncogene, here, we produced a high-throughput profiling of genes modulated by miR-15a/16-1 in a leukemic cell line model (MEG-01) and in primary CLL samples. By combining experimental and bioinformatics data, we identified a miR-15a/16-1-gene signature in leukemic cells. Among the components of the miR-15a/16-1 signature, we observed a statistically significant enrichment in AU-rich elements (AREs). By examining the Gene Ontology (GO) database, a significant enrichment in cancer genes (such as MCL1, BCL2, ETS1, or JUN) that directly or indirectly affect apoptosis and cell cycle was found.

Maintenance Strategies and Romantic Relationship Type, Gender and Relational Characteristics

Abstract: This study examines the manner in which perceptions of relational maintenance strategies used in romantic dyads vary according to relationship type (married, engaged, seriously dating and dating) and gender. Additionally, this study investigates how perceptions of partners' maintenance behaviors differentially affect the relational characteristics of control mutuality, commitment, liking and satisfaction. Research assumptions were cast within a developmental framework. Five maintenance strategies were derived through factor analyses: positivity, assurances, openness, sharing tasks and social networks. Results indicate that relationship type moderately affected perceptions of partner maintenance strategies and gender weakly affected perceptions of maintenance behaviors. The findings also reveal that positivity, assurances and sharing tasks were consistent and strong predictors of control mutuality, commitment, liking and satisfaction.

Investigating variation in replicability: A “Many Labs” replication project

Abstract: Although replication is a central tenet of science, direct replications are rare in psychology. This research tested variation in the replicability of 13 classic and contemporary effects across 36 independent samples totaling 6,344 participants. In the aggregate, 10 effects replicated consistently. One effect – imagined contact reducing prejudice – showed weak support for replicability. And two effects – flag priming influencing conservatism and currency priming influencing system justification – did not replicate. We compared whether the conditions such as lab versus online or US versus international sample predicted effect magnitudes. By and large they did not. The results of this small sample of effects suggest that replicability is more dependent on the effect itself than on the sample and setting used to investigate the effect.