Institution
Ohio State University
Education•Columbus, Ohio, United States•
About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.
Topics: Population, Poison control, Galaxy, Cancer, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors show that most wetlands, when compared to methane emissions, do not have 25 times more CO2 sequestration than methane emissions; therefore, to many landscape managers and non specialists, most wetlands would be considered by some to be sources of climate warming or net radiative forcing.
Abstract: Wetland ecosystems provide an optimum natural environment for the sequestration and long-term storage of carbon dioxide (CO2) from the atmosphere, yet are natural sources of greenhouse gases emissions, especially methane. We illustrate that most wetlands, when carbon sequestration is compared to methane emissions, do not have 25 times more CO2 sequestration than methane emissions; therefore, to many landscape managers and non specialists, most wetlands would be considered by some to be sources of climate warming or net radiative forcing. We show by dynamic modeling of carbon flux results from seven detailed studies by us of temperate and tropical wetlands and from 14 other wetland studies by others that methane emissions become unimportant within 300 years compared to carbon sequestration in wetlands. Within that time frame or less, most wetlands become both net carbon and radiative sinks. Furthermore, we estimate that the world’s wetlands, despite being only about 5–8 % of the terrestrial landscape, may currently be net carbon sinks of about 830 Tg/year of carbon with an average of 118 g-C m−2 year−1 of net carbon retention. Most of that carbon retention occurs in tropical/subtropical wetlands. We demonstrate that almost all wetlands are net radiative sinks when balancing carbon sequestration and methane emissions and conclude that wetlands can be created and restored to provide C sequestration and other ecosystem services without great concern of creating net radiative sources on the climate due to methane emissions.
752 citations
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TL;DR: The authors found that the more attention media pay to a particular domain, the more the public will incorporate what they know about that domain into their overall judgment of the president, and that intervention in Central America loomed larger in the public's assessment of President Reagan's performance after the Iran-Contra disclosure than before.
Abstract: The disclosure that high officials within the Reagan administration had covertly diverted to the Nicaraguan Contras funds obtained from the secret sale of weapons to Iran provides us with a splendid opportunity to examine how the foundations of popular support shift when dramatic events occur. According to our theory of priming, the more attention media pay to a particular domain—the more the public is primed with it—the more citizens will incorporate what they know about that domain into their overall judgment of the president. Data from the 1986 National Election Study confirm that intervention in Central America loomed larger in the public's assessment of President Reagan's performance after the Iran-Contra disclosure than before. Priming was most pronounced for aspects of public opinion most directly implicated by the news coverage, more apparent in political notices' judgments than political experts', and stronger in the evaluations of Reagan's overall performance than in assessments of his character.
752 citations
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TL;DR: A formal 2-dimensional conception of autonomic space is proposed, and a quantitative model for its translation into a functional output surface is derived and has fundamental implications for the direction and interpretation of a wide array of psychophysiological studies.
Abstract: Contemporary findings reveal that the multiple modes of autonomic control do not lie along a single continuum extending from parasympathetic to sympathetic dominance but rather distribute within a 2-dimensional space. The physiological origins and empirical documentation for the multiple modes of autonomic control are considered. Then a formal 2-dimensional conception of autonomic space is proposed, and a quantitative model for its translation into a functional output surface is derived. It is shown that this model (a) accounts for much of the error variance that has traditionally plagued psychophysiological studies, (b) subsumes psychophysiological principles such as the law of initial values, (c) gives rise to formal laws of autonomic constraint, and (d) has fundamental implications for the direction and interpretation of a wide array of psychophysiological studies.
752 citations
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28 Aug 2005TL;DR: The notion of k-barrier coverage of a belt region using wireless sensors is defined, and efficient algorithms are proposed using which one can quickly determine, after deploying the sensors, whether a region is k- barrier covered.
Abstract: In old times, castles were surrounded by moats (deep trenches filled with water, and even alligators) to thwart or discourage intrusion attempts. One can now replace such barriers with stealthy and wireless sensors. In this paper, we develop theoretical foundations for laying barriers of wireless sensors. We define the notion of k-barrier coverage of a belt region using wireless sensors. We propose efficient algorithms using which one can quickly determine, after deploying the sensors, whether a region is k-barrier covered. Next, we establish the optimal deployment pattern to achieve k-barrier coverage when deploying sensors deterministically. Finally, we consider barrier coverage with high probability when sensors are deployed randomly. We introduce two notions of probabilistic barrier coverage in a belt region -- weak and strong barrier coverage. While weak barrier-coverage with high probability guarantees the detection of intruders as they cross a barrier of stealthy sensors, a sensor network providing strong barrier-coverage with high probability (at the expense of more sensors) guarantees the detection of all intruders crossing a barrier of sensors, even when the sensors are not stealthy. Both types of barrier coverage require significantly less number of sensors than full-coverage, where every point in the region needs to be covered. We derive critical conditions for weak k-barrier coverage, using which one can compute the minimum number of sensors needed to provide weak k-barrier coverage with high probability in a given belt region. Deriving critical conditions for strong k-barrier coverage for a belt region is still an open problem.
751 citations
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TL;DR: The extant genetic and phenotypic heterogeneity in CRC leads to the conclusion that it is no longer appropriate to discuss the genetics of CRC without defining the specific hereditary CRC syndrome of concern, and a detailed differential diagnosis of the several hereditary CRC variants is provided.
Abstract: Familial colorectal cancer (CRC) is a major public health problem by virtue of its relatively high frequency. Some 15-20% of all CRCs are familial. Among these, familial adenomatous polyposis (FAP), caused by germline mutations in the APC gene, accounts for less than 1%. Hereditary non-polyposis colorectal cancer (HNPCC), also called Lynch syndrome, accounts for approximately 5-8% of all CRC patients. Among these, some 3% are mutation positive, that is, caused by germline mutations in the DNA mismatch repair genes that have so far been implicated (MLH1, MSH2, MSH6, PMS1, and PMS2). Most of the remaining patients belonging to HNPCC or HNPCC-like families are still molecularly unexplained. Among the remaining familial CRCs, a large proportion is probably caused by gene mutations and polymorphisms of low penetrance, of which the I1307K polymorphism in the APC gene is a prime example. Molecular genetic findings have enabled hereditary CRC to be divided into two groups: (1) tumours that show microsatellite instability (MSI), occur more frequently in the right colon, have diploid DNA, harbour characteristic mutations such as transforming growth factor ‚ type II receptor and BAX, and behave indolently, of which HNPCC is an example; and (2) tumours with chromosomal instability (CIN), which tend to be left sided, show aneuploid DNA, harbour characteristic mutations such as K-ras, APC, and p53, and behave aggressively, of which FAP is an example. This review focuses most heavily on the clinical features, pathology, molecular genetics, surveillance, and management including prophylactic surgery in HNPCC. Because of the diYculty in diagnosing HNPCC, a detailed diVerential diagnosis of the several hereditary CRC variants is provided. The extant genetic and phenotypic heterogeneity in CRC leads to the conclusion that it is no longer appropriate to discuss the genetics of CRC without defining the specific hereditary CRC syndrome of concern. Therefore, it is important to ascertain cancer of all anatomical sites, as well as non-cancer phenotypic stigmata (such as the perioral and mucosal pigmentations in PeutzJeghers syndrome), when taking a family cancer history. (J Med Genet 1999;36:801‐818)
751 citations
Authors
Showing all 103197 results
Name | H-index | Papers | Citations |
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Paul M. Ridker | 233 | 1242 | 245097 |
George Davey Smith | 224 | 2540 | 248373 |
Carlo M. Croce | 198 | 1135 | 189007 |
Eric J. Topol | 193 | 1373 | 151025 |
Bernard Rosner | 190 | 1162 | 147661 |
David H. Weinberg | 183 | 700 | 171424 |
Anil K. Jain | 183 | 1016 | 192151 |
Michael I. Jordan | 176 | 1016 | 216204 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Richard K. Wilson | 173 | 463 | 260000 |
Yang Yang | 164 | 2704 | 144071 |
Brian L Winer | 162 | 1832 | 128850 |
Jian-Kang Zhu | 161 | 550 | 105551 |
Elaine R. Mardis | 156 | 485 | 226700 |
R. E. Hughes | 154 | 1312 | 110970 |