Ohio State University

About: Ohio State University is a education organization based out in Columbus, Ohio, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 102421 authors who have published 222715 publications receiving 8373403 citations. The organization is also known as: Ohio State & The Ohio State University.

Bayesian Statistics: An Introduction

Abstract: Bayesian Statistics is the school of thought that combines prior beliefs with the likelihood of a hypothesis to arrive at posterior beliefs. The first edition of Peter Lees book appeared in 1989, but the subject has moved ever onwards, with increasing emphasis on Monte Carlo based techniques.This new fourth edition looks at recent techniques such as variational methods, Bayesian importance sampling, approximate Bayesian computation and Reversible Jump Markov Chain Monte Carlo (RJMCMC), providing a concise account of the way in which the Bayesian approach to statistics develops as well as how it contrasts with the conventional approach. The theory is built up step by step, and important notions such as sufficiency are brought out of a discussion of the salient features of specific examples.This edition:Includes expanded coverage of Gibbs sampling, including more numerical examples and treatments of OpenBUGS, R2WinBUGS and R2OpenBUGS.Presents significant new material on recent techniques such as Bayesian importance sampling, variational Bayes, Approximate Bayesian Computation (ABC) and Reversible Jump Markov Chain Monte Carlo (RJMCMC).Provides extensive examples throughout the book to complement the theory presented.Accompanied by a supporting website featuring new material and solutions.More and more students are realizing that they need to learn Bayesian statistics to meet their academic and professional goals. This book is best suited for use as a main text in courses on Bayesian statistics for third and fourth year undergraduates and postgraduate students.

The Trouble With Overconfidence

Abstract: This paper presents a reconciliation of the three distinct ways in which the research literature has defined overconfidence: (1) overestimation of one's actual performance, (2) overplacement of one's performance relative to others, and (3) excessive precision in one's beliefs. Experimental evidence shows that reversals of the first two (apparent underconfidence), when they occur, tend to be on different types of tasks. On difficult tasks, people overestimate their actual performances but also believe that they are worse than others; on easy tasks, people underestimate their actual performances but believe they are better than others. This paper offers a straightforward theory that can explain these inconsistencies. Overprecision appears to be more persistent than either of the other two types of overconfidence, but its presence reduces the magnitude of both overestimation and overplacement.

Targeting microRNAs in cancer: rationale, strategies and challenges.

Abstract: MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate gene expression. Early studies have shown that miRNA expression is deregulated in cancer and experimental data indicate that cancer phenotypes can be modified by targeting miRNA expression. Based on these observations, miRNA-based anticancer therapies are being developed, either alone or in combination with current targeted therapies, with the goal to improve disease response and increase cure rates. The advantage of using miRNA approaches is based on its ability to concurrently target multiple effectors of pathways involved in cell differentiation, proliferation and survival. In this Review, we describe the role of miRNAs in tumorigenesis and critically discuss the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer.

Nanotribology: friction, wear and lubrication at the atomic scale

Abstract: Friction, wear and lubrication between materials in contact are of fundamental importance in many pure and applied sciences. Owing to the development of experimental and computer-simulation techniques for studying these phenomena at the atomic scale, an understanding is beginning to emerge of the molecular mechanisms of tribology in thin films and at surfaces.