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Showing papers by "Oklahoma State University–Stillwater published in 2007"


Journal ArticleDOI
TL;DR: Current literature examining associations between components of the family context and children and adolescents' emotion regulation (ER) and a tripartite model of familial influence posited that children learn about ER through observational learning, modeling and social referencing.
Abstract: This article reviews current literature examining associations between components of the family context and children and adolescents' emotion regulation (ER). The review is organized around a tripartite model of familial influence. Firstly, it is posited that children learn about ER through observational learning, modeling and social referencing. Secondly, parenting practices specifically related to emotion and emotion management affect ER. Thirdly, ER is affected by the emotional climate of the family via parenting style, the attachment relationship, family expressiveness and the marital relationship. The review ends with discussions regarding the ways in which child characteristics such as negative emotionality and gender affect ER, how socialization practices change as children develop into adolescents, and how parent characteristics such as mental health affect the socialization of ER.

2,091 citations


Journal ArticleDOI
TL;DR: The proposed VSNR metric is generally competitive with current metrics of visual fidelity; it is efficient both in terms of its low computational complexity and in termsof its low memory requirements; and it operates based on physical luminances and visual angle (rather than on digital pixel values and pixel-based dimensions) to accommodate different viewing conditions.
Abstract: This paper presents an efficient metric for quantifying the visual fidelity of natural images based on near-threshold and suprathreshold properties of human vision. The proposed metric, the visual signal-to-noise ratio (VSNR), operates via a two-stage approach. In the first stage, contrast thresholds for detection of distortions in the presence of natural images are computed via wavelet-based models of visual masking and visual summation in order to determine whether the distortions in the distorted image are visible. If the distortions are below the threshold of detection, the distorted image is deemed to be of perfect visual fidelity (VSNR = infin)and no further analysis is required. If the distortions are suprathreshold, a second stage is applied which operates based on the low-level visual property of perceived contrast, and the mid-level visual property of global precedence. These two properties are modeled as Euclidean distances in distortion-contrast space of a multiscale wavelet decomposition, and VSNR is computed based on a simple linear sum of these distances. The proposed VSNR metric is generally competitive with current metrics of visual fidelity; it is efficient both in terms of its low computational complexity and in terms of its low memory requirements; and it operates based on physical luminances and visual angle (rather than on digital pixel values and pixel-based dimensions) to accommodate different viewing conditions.

1,153 citations


Journal ArticleDOI
TL;DR: In this article, a review focuses on recent advances, with emphasis on integration of small RNAs in stress regulatory networks, and shows that smallRNAs are involved in plant stress responses.

829 citations


Journal ArticleDOI
TL;DR: In 2 time-lagged samples, the authors found that motivation mediates the emotional exhaustion-job performance relationship and participants appear to target their investment of resources in response to emotional exhaustion to develop social support through social exchange.
Abstract: The literature concerning the relationship between emotional exhaustion and performance led researchers to raise questions about the extent to which the variables are related. In 2 time-lagged samples, the authors found that motivation mediates the emotional exhaustion-job performance relationship. Moreover, the authors found that participants appear to target their investment of resources in response to emotional exhaustion to develop social support through social exchange; specifically, emotional exhaustion was associated with communion striving resources that were manifest in the form of organizational citizenship behaviors targeted at individuals. Implications of this relationship for theories of burnout and for management practice are discussed.

755 citations


Journal ArticleDOI
TL;DR: A review of neutrino mass physics can be found in this paper, where the authors summarize what can be learned about neutrinos interactions as well as the nature of new physics beyond the Standard Model from various proposed Neutrino experiments.
Abstract: This paper is a review of the present status of neutrino mass physics, which grew out of an APS sponsored study of neutrinos in 2004. After a discussion of the present knowledge of neutrino masses and mixing and some popular ways to probe the new physics implied by recent data, it summarizes what can be learned about neutrino interactions as well as the nature of new physics beyond the Standard Model from the various proposed neutrino experiments. The intriguing possibility that neutrino mass physics may be at the heart of our understanding of a long standing puzzle of cosmology, i.e. the origin of matter?antimatter asymmetry is also discussed.

496 citations


Journal ArticleDOI
TL;DR: The Oklahoma Mesonet as mentioned in this paper is a multipurpose network with more than 110 surface observing stations that send data every 5 min to an operations center for data quality assurance, product generation, and dissemination.
Abstract: Established as a multipurpose network, the Oklahoma Mesonet operates more than 110 surface observing stations that send data every 5 min to an operations center for data quality assurance, product generation, and dissemination. Quality-assured data are available within 5 min of the observation time. Since 1994, the Oklahoma Mesonet has collected 3.5 billion weather and soil observations and produced millions of decision-making products for its customers.

463 citations


Journal ArticleDOI
TL;DR: This survey reviews the latest developments in DNA motif finding algorithms and reports to correctly detect the motifs that have been previously detected by laboratory experimental approaches, and some algorithms were able to find novel motifs.
Abstract: Background: Unraveling the mechanisms that regulate gene expression is a major challenge in biology. An important task in this challenge is to identify regulatory elements, especially the binding sites in deoxyribonucleic acid (DNA) for transcription factors. These binding sites are short DNA segments that are called motifs. Recent advances in genome sequence availability and in highthroughput gene expression analysis technologies have allowed for the development of computational methods for motif finding. As a result, a large number of motif finding algorithms have been implemented and applied to various motif models over the past decade. This survey reviews the latest developments in DNA motif finding algorithms. Results: Earlier algorithms use promoter sequences of coregulated genes from single genome and search for statistically overrepresented motifs. Recent algorithms are designed to use phylogenetic footprinting or orthologous sequences and also an integrated approach where promoter sequences of coregulated genes and phylogenetic footprinting are used. All the algorithms studied have been reported to correctly detect the motifs that have been previously detected by laboratory experimental approaches, and some algorithms were able to find novel motifs. However, most of these motif finding algorithms have been shown to work successfully in yeast and other lower organisms, but perform significantly worse in higher organisms. Conclusion: Despite considerable efforts to date, DNA motif finding remains a complex challenge for biologists and computer scientists. Researchers have taken many different approaches in developing motif discovery tools and the progress made in this area of research is very encouraging. Performance comparison of different motif finding tools and identification of the best tools have proven to be a difficult task because tools are designed based on algorithms and motif models that are diverse and complex and our incomplete understanding of the biology of regulatory mechanism does not always provide adequate evaluation of underlying algorithms over motif models.

448 citations


Book
01 Jan 2007
TL;DR: Experimental auctions circumvent this problem by allowing individuals to exchange real money for real goods in an active market as mentioned in this paper, which represents a promising means for eliciting non-market values, and is a valuable resource to graduate students, practitioners and researchers concerned with the design and utilization of experimental auctions in applied economic and marketing research.
Abstract: Economists, psychologists, and marketers are interested in determining the monetary value people place on non-market goods for a variety of reasons: to carry out cost-benefit analysis, to determine the welfare effects of technological innovation or public policy, to forecast new product success, and to understand individual and consumer behavior. Unfortunately, many currently available techniques for eliciting individuals' values suffer from a serious problem in that they involve asking individuals hypothetical questions about intended behavior. Experimental auctions circumvent this problem because they involve individuals exchanging real money for real goods in an active market. This represents a promising means for eliciting non-market values. Lusk and Shogren provide a comprehensive guide to the theory and practice of experimental auctions. It will be a valuable resource to graduate students, practitioners and researchers concerned with the design and utilization of experimental auctions in applied economic and marketing research.

445 citations


Journal ArticleDOI
TL;DR: Empirical findings could be used to prepare businesses for the similar epidemics, such as a deadly bird-flu epidemic, indicating a significant impact of the SARS outbreak on hotel stock performance.

422 citations


Journal ArticleDOI
TL;DR: Two hybrid approaches for modeling IDS are presented as a hierarchical hybrid intelligent system model (DT-SVM) and an ensemble approach combining the base classifiers to maximize detection accuracy and minimize computational complexity.

409 citations


Journal ArticleDOI
TL;DR: In this article, a comparison of the performance of 68 void fraction correlations based on unbiased data set (2845 data points) covering wide range of parameters than previous assessments was made.

Proceedings ArticleDOI
03 Jun 2007
TL;DR: An open source, variation aware Process Design Kit (PDK), based on Scalable CMOS design rules, down to 45 nm, for use in VLSI research, education and small businesses is discussed.
Abstract: This paper discusses an open source, variation aware Process Design Kit (PDK), based on Scalable CMOS design rules, down to 45 nm,for use in VLSI research, education and small businesses. This kit includes all the necessary layout design rules and extraction command decks to capture layout dependent systematic variation and perform statistical circuit analysis. The kit also includes a standard cell and pad library with the necessary support files to enable full chip place and route and verification for System on Chip designs. Test chips designed with this PDK are designed in such a way so that they can be fabricated by fabrication facilities allowing validation of the design rules so that the rules may be used in future multi-project runs and design contests.

Journal ArticleDOI
TL;DR: This study provides a first large scale cloning and characterization of wheat miRNAs and their predicted targets, and indicates that both conserved and wheat-specific miRNas play important roles in wheat growth and development, stress responses and other physiological processes.
Abstract: MicroRNAs (miRNAs) are a class of small, non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition. So far, identification of miRNAs has been limited to a few model plant species, such as Arabidopsis, rice and Populus, whose genomes have been sequenced. Wheat is one of the most important cereal crops worldwide. To date, only a few conserved miRNAs have been predicted in wheat and the computational identification of wheat miRNAs requires the genome sequence, which is unknown. To identify novel as well as conserved miRNAs in wheat (Triticum aestivum L.), we constructed a small RNA library. High throughput sequencing of the library and subsequent analysis revealed the identification of 58 miRNAs, comprising 43 miRNA families. Of these, 35 miRNAs belong to 20 conserved miRNA families. The remaining 23 miRNAs are novel and form 23 miRNA families in wheat; more importantly, 4 of these new miRNAs (miR506, miR510, miR514 and miR516) appear to be monocot-specific. Northern blot analysis indicated that some of the new miRNAs are preferentially expressed in certain tissues. Based on sequence homology, we predicted 46 potential targets. Thus, we have identified a large number of monocot-specific and wheat-specific miRNAs. These results indicate that both conserved and wheat-specific miRNAs play important roles in wheat growth and development, stress responses and other physiological processes. This study led to the discovery of 58 wheat miRNAs comprising 43 miRNA families; 20 of these families are conserved and 23 are novel in wheat. It provides a first large scale cloning and characterization of wheat miRNAs and their predicted targets.

Journal ArticleDOI
01 Apr 2007
TL;DR: This article focuses on model-driven DSS built using decision analysis, optimization, and simulation technologies; implementation using spreadsheet and web technologies; issues associated with the user interface; and behavioral and technical research questions.
Abstract: In some decision situations, quantitative models embedded in a Decision Support System (DSS) can help managers make better decisions. Model-driven DSS use algebraic, decision analytic, financial, simulation, and optimization models to provide decision support. This category of DSS is continuing to evolve, but research can resolve a variety of behavioral and technical issues that impact system performance, acceptance and adoption. This article includes a brief survey of prior research. It focuses on model-driven DSS built using decision analysis, optimization, and simulation technologies; implementation using spreadsheet and web technologies; issues associated with the user interface; and behavioral and technical research questions.

Journal ArticleDOI
TL;DR: Commercial tick vaccines for cattle based on the Boophilus microplus Bm86 gut antigen have proven to be a feasible tick control method that offers a cost-effective, environmentally friendly alternative to the use of acaricides.
Abstract: Ticks are important ectoparasites of domestic and wild animals, and tick infestations economically impact cattle production worldwide. Control of cattle tick infestations has been primarily by application of acaricides which has resulted in selection of resistant ticks and environmental pollution. Herein we discuss data from tick vaccine application in Australia, Cuba, Mexico and other Latin American countries. Commercial tick vaccines for cattle based on the Boophilus microplus Bm86 gut antigen have proven to be a feasible tick control method that offers a cost-effective, environmentally friendly alternative to the use of acaricides. Commercial tick vaccines reduced tick infestations on cattle and the intensity of acaricide usage, as well as increasing animal production and reducing transmission of some tick-borne pathogens. Although commercialization of tick vaccines has been difficult owing to previous constraints of antigen discovery, the expense of testing vaccines in cattle, and company restructuring, the success of these vaccines over the past decade has clearly demonstrated their potential as an improved method of tick control for cattle. Development of improved vaccines in the future will be greatly enhanced by new and efficient molecular technologies for antigen discovery and the urgent need for a tick control method to reduce or replace the use of acaricides, especially in regions where extensive tick resistance has occurred.

Journal ArticleDOI
TL;DR: A framework of information on Tribolium immunity is established, which may serve as a stepping stone for future genetic analyses of defense responses in a nondrosophiline genetic model insect.
Abstract: Tribolium castaneum is a species of Coleoptera, the largest and most diverse order of all eukaryotes. Components of the innate immune system are hardly known in this insect, which is in a key phylogenetic position to inform us about genetic innovations accompanying the evolution of holometabolous insects. We have annotated immunity-related genes and compared them with homologous molecules from other species. Around 300 candidate defense proteins are identified based on sequence similarity to homologs known to participate in immune responses. In most cases, paralog counts are lower than those of Drosophila melanogaster or Anopheles gambiae but are substantially higher than those of Apis mellifera. The genome contains probable orthologs for nearly all members of the Toll, IMD, and JAK/STAT pathways. While total numbers of the clip-domain serine proteinases are approximately equal in the fly (29), mosquito (32) and beetle (30), lineage-specific expansion of the family is discovered in all three species. Sixteen of the thirty-one serpin genes form a large cluster in a 50 kb region that resulted from extensive gene duplications. Among the nine Toll-like proteins, four are orthologous to Drosophila Toll. The presence of scavenger receptors and other related proteins indicates a role of cellular responses in the entire system. The structures of some antimicrobial peptides drastically differ from those in other orders of insects. A framework of information on Tribolium immunity is established, which may serve as a stepping stone for future genetic analyses of defense responses in a nondrosophiline genetic model insect.

Journal ArticleDOI
TL;DR: In this article, two oxidation protocols, sonication in 8 M HNO3 at 40 °C and reflux in 2.6 M H NO3, have been examined using carbon nanotubes produced by the CoMoCat, HiPco, and pulsed laser vaporization (PLV) methods.
Abstract: Oxidation of single-walled carbon nanotubes (SWNTs) with nitric acid increases their dispersability in water, methanol, and N,N-dimethylformamide. Two oxidation protocols, sonication in 8 M HNO3 at 40 °C and reflux in 2.6 M HNO3, have been examined using SWNTs produced by the CoMoCat, HiPco, and pulsed laser vaporization (PLV) methods. The dispersability of all types of nanotubes increased substantially after 1 h of sonication and after 2−4 h of reflux. Longer treatments resulted in little further improvement in dispersability and at reflux degraded the SWNTs. Stable dispersions of CoMoCat SWNTs in DMF at concentrations as high as 0.4 g/L were achieved without the use of surfactants or polymers. Raman spectroscopy showed greater covalent functionalization of the SWNTs by the reflux procedure than by the sonication procedure. Concurrent with improved dispersability, oxidation resulted in smaller diameters and shorter lengths as determined from AFM images, which show mostly bundles rather than individual tu...

Journal ArticleDOI
TL;DR: This paper explored the influence of perceived IT beliefs, task-technology fit, attitude, self-efficacy, and subjective norm on behavioral intention of adopting information technology in hotels in Hangzhou, China.

Journal ArticleDOI
TL;DR: Infection assays, metabolic profiling, and gene expression results indicate that the intact COR molecule is required for both suppression of SA-mediated defense responses and full disease symptom development in tomato.
Abstract: The roles of the phytotoxin coronatine (COR) and salicylic acid (SA)-mediated defenses in the interaction of Pseudomonas syringae pv. tomato DC3000 and tomato (Solanum lycopersicum) were investigated. Unlike findings reported for Arabidopsis thaliana, DC3000 mutants impaired for production of COR or one of its components, coronafacic acid (CFA) or coronamic acid (CMA), induced distinctly different disease lesion phenotypes in tomato. Tomato plants inoculated with the CFA- CMA- mutant DB29 showed elevated transcript levels of SlICS, which encodes isochorismate synthase, an enzyme involved in SA biosynthesis in S. lycopersicum. Furthermore, expression of genes encoding SA-mediated defense proteins were elevated in DB29-inoculated plants compared with plants inoculated with DC3000, suggesting that COR suppresses SlICS-mediated SA responses. Sequence analysis of SlICS revealed that it encodes a protein that is 55 and 59.6% identical to the A. thaliana ICS-encoded proteins AtICS1 and AtICS2, respectively. Tomato plants silenced for SlICS were hypersusceptible to DC3000 and accumulated lower levels of SA after infection with DC3000 compared with inoculated wild-type tomato plants. Unlike what has been shown for A. thaliana, the COR- mutant DB29 was impaired for persistence in SlICS-silenced tomato plants; thus, COR has additional roles in virulence that are SA independent and important in the latter stages of disease development. In summary, the infection assays, metabolic profiling, and gene expression results described in this study indicate that the intact COR molecule is required for both suppression of SA-mediated defense responses and full disease symptom development in tomato.

Journal ArticleDOI
TL;DR: It is shown that for iron phthalocyanine a Kondo temperature in spectroscopic measurements which is well above room temperature is found, and that the signal of the resonance depends strongly on the adsorption site of the molecule on a gold surface.
Abstract: Kondo resonances are a very precise measure of spin-polarized transport through magnetic impurities. However, the Kondo temperature, indicating the thermal range of stability of the magnetic properties, is very low. By contrast, we find for iron phthalocyanine a Kondo temperature in spectroscopic measurements which is well above room temperature. It is also shown that the signal of the resonance depends strongly on the adsorption site of the molecule on a gold surface. Experimental data are verified by extensive numerical simulations, which establish that the coupling between iron states and states of the substrate depends strongly on the adsorption configuration.

Journal ArticleDOI
TL;DR: The authors found that individual differences in political skill and perceptions of organizational support will be negatively related to burnout and will also moderate the relationship between perceived role conflict and burnout, and that perceived organizational support was associated with less emotional exhaustion and depersonalization.
Abstract: Drawing from previous research on the effect of role conflict on burnout and the Conservation of Resources theory, the authors propose that individual differences in political skill and perceptions of organizational support will be negatively related to burnout and will also moderate the relationship between perceived role conflict and burnout. In a sample of 120 professional employees, political skill was associated with less depersonalization and feelings of reduced personal accomplishment and moderated the role conflict-reduced personal accomplishment relationship. Perceived organizational support was associated with less emotional exhaustion and depersonalization and moderated the role conflict-emotional exhaustion relationship. Implications of results are discussed and directions for future research are offered.

Journal ArticleDOI
TL;DR: In this paper, the authors present a procedure for standard application of hydrologic/water quality models, which is an adaptation and extension of steps identified from relevant literature including guidance provided by the U.S. Environmental Protection Agency.
Abstract: This paper presents a procedure for standard application of hydrologic/water quality models. To date, most hydrologic/water quality modeling projects and studies have not utilized formal protocols, but rather have employed ad hoc approaches. The procedure proposed is an adaptation and extension of steps identified from relevant literature including guidance provided by the U.S. Environmental Protection Agency. This protocol provides guidance for establishing written plans prior to conducting modeling efforts. Eleven issues that should be addressed in model application plans were identified and discussed in the context of hydrologic/water quality studies. A graded approach for selection of the level of documentation for each item was suggested. The creation and use of environmental modeling plans is increasingly important as the results of modeling projects are used in decision-making processes that have significant implications. Standard modeling application protocols similar to the proposed procedure herein provide modelers with a roadmap to be followed, reduces modelers’ bias, enhances the reproducibility of model application studies, and eventually improves acceptance of modeling outcomes.

Journal ArticleDOI
TL;DR: In this paper, the authors used HPLC and flame atomic absorption spectrophotometry (AAS) for phytate analysis of foods from enset and tef in Southern Ethiopia.

Journal ArticleDOI
TL;DR: In this article, the authors demonstrate the importance of streambank composition and stratigraphy in controlling seepage flow and quantify correlation of seepages flow/erosion with precipitation, stream stage and soil pore water pressure.
Abstract: Limited information exists on one of the mechanisms governing sediment input to streams: streambank erosion by ground water seepage. The objective of this research was to demonstrate the importance of streambank composition and stratigraphy in controlling seepage flow and to quantify correlation of seepage flow/erosion with precipitation, stream stage and soil pore water pressure. The streambank site was located in Northern Mississippi in the Goodwin Creek watershed. Soil samples from layers on the streambank face suggested less than an order of magnitude difference in vertical hydraulic conductivity (Ks) with depth, but differences between lateral Ks of a concretion layer and the vertical Ks of the underlying layers contributed to the propensity for lateral flow. Goodwin Creek seeps were not similar to other seeps reported in the literature, in that eroded sediment originated from layers underneath the primary seepage layer. Subsurface flow and sediment load, quantified using 50 cm wide collection pans, were dependent on the type of seep: intermittent low-flow (LF) seeps (flow rates typically less than 0·05 L min−1), persistent high-flow (HF) seeps (average flow rate of 0·39 L min−1) and buried seeps, which eroded unconsolidated bank material from previous bank failures. The timing of LF seeps correlated to river stage and precipitation. The HF seeps at Goodwin Creek began after rainfall events resulted in the adjacent streambank reaching near saturation (i.e. soil pore water pressures greater than −5 kPa). Seep discharge from HF seeps reached a maximum of 1·0 L min−1 and sediment concentrations commonly approached 100 g L−1. Buried seeps were intermittent but exhibited the most significant erosion rates (738 g min−1) and sediment concentrations (989 g L−1). In cases where perched water table conditions exist and persistent HF seeps occur, seepage erosion and bank collapse of streambank sediment may be significant. Copyright © 2007 John Wiley & Sons, Ltd.

Journal ArticleDOI
TL;DR: In this paper, optical sensor readings of normalized difference vegetation index (NDVI) and plant height measurements were collected on individual corn plants at various growth stages ranging from V8 to V10 (collar of 10th leaf unfolded) growth stage can distinguish individual plants and provide information as to their biomass accumulation and N uptake.
Abstract: As research intensifies on developing precision agricultural practices for corn (Zea mays L.) production, an important component will be to identify the scale at which these practices should be implemented. We hypothesized that optical sensing can be used to measure individual corn plant biomass and N uptake. A 3-yr study was conducted at three locations in Oklahoma. Optical sensor readings of normalized difference vegetation index (NDVI) and plant height measurements were collected on individual corn plants at various growth stages ranging from V8 (collar of eighth leaf unfolded) to VT (last branch of the tassel is completely visible) and correlated with individual plant biomass, forage yield per unit area occupied by the plant, and N uptake of that plant. Individual plant height measurement, collected before reproductive growth, was a good predictor of plant biomass across the six site years of the study (r 2 = 0.81). The index of NDVI X plant height provided the highest correlation with by-plant forage yield on an area basis. Optical sensor and plant height measurements collected at the V8 to V10 (collar of 10th leaf unfolded) growth stage can distinguish individual plants and provide information as to their biomass accumulation and N uptake. This research demonstrates that by-plant information can be collected and used to direct high resolution N applications. The index, NDVI X plant height, may be used to refine midseason fertilizer N rates based on expected N removal and by-plant measurements at or before V10.

Journal ArticleDOI
TL;DR: The authors suggest that a 3-dimensional modified NEP Scale for Children, with 10 instead of 15 items and revised wording, is appropriate for use with children aged 10-12 years.
Abstract: The authors revised and validated the New Ecological Paradigm (NEP) Scale for use with upper elementary students Researchers use the NEP Scale extensively with adults, but it was not designed for children Interviews with 5th grade students helped the authors revise the NEP Scale for use with children The authors spent 2 years validating the modified instrument with larger numbers of students After analyzing their results, the authors suggest that a 3-dimensional modified NEP Scale for Children, with 10 instead of 15 items and revised wording, is appropriate for use with children aged 10-12 years

Journal ArticleDOI
TL;DR: Proper sample handling, storage, and interpretation of the erythron, serum iron indices, leukon, and acute-phase proteins for cattle, sheep, and goats is addressed.
Abstract: The complete blood cell count can provide valuable diagnostic and prognostic information when coupled with a thorough physical examination. This article addresses proper sample handling, storage, and interpretation of the erythron, serum iron indices, leukon, and acute-phase proteins for cattle, sheep, and goats.

Journal ArticleDOI
TL;DR: In this article, the authors examined how online traveler's decision-making paradigm may vary according to the traveler's personal innovativeness level, by utilizing Fishbein and Ajzen's (1975, Belief, attitude, intention and behavior).

Journal ArticleDOI
TL;DR: Systematic studies are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations.
Abstract: Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC). Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment. Extensive literature search was conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLA DR13 is consistently associated with HBV clearance globally. HLADRB1*11/*12 alleles and DQB1*0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class I molecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific therapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations.

Journal ArticleDOI
TL;DR: In this article, the authors investigated the effects of different fertilization treatments on total and DTPA-extractable micronutrients in soils and in crops after 16 year fertilization experiments in Fengqiu County, Henan Province, China.
Abstract: Micronutrient status in soils and crops can be affected by different fertilization practices during a long-term field experiment. This paper investigated the effects of different fertilization treatments on total and DTPA-extractable micronutrients in soils and micronutrients in crops after 16 year fertilization experiments in Fengqiu County, Henan Province, China. The treatments of the long-term experiment included combinations of various rates of N, P and K in addition to two rates of organic fertilizer (OF) treatments. Winter wheat and summer maize were planted annually. Soil macro- and micronutrients along with pH and organic matter (OM) were analyzed. Grains and above ground parts of both crops in the final year were harvested and analyzed for Cu, Zn, Fe and Mn. The results showed that soil Cu, Zn, Fe and Mn concentrations did not change among the different treatments to a significant level, except for a slight decrease of soil Zn in the CK (no fertilizer application) compared to the OF treatment. The DTPA-extractable soil Zn, Fe and Mn concentrations increased from 0.41 to 1.08 mg kg −1 , from 10.3 to 17.7 mg kg −1 , and from 9.7 to 11.8 mg kg −1 , respectively, with increasing soil OM content, thus showing the importance of soil OM in micronutrient availability for crops. The NPK treatment also had higher DTPA-extractable micronutrient concentrations in soil. Deficiency of N or P resulted in a low yield but high micronutrient concentrations in crops except Cu in maize stalks. Higher available soil P significantly decreased crop micronutrients, possibly because of their precipitation as metal phosphates. Maize stalks contained higher concentrations of micronutrients than those of wheat straw, whereas wheat grain had higher micronutrients than those of corn grain. The transfer coefficients (TCs) of micronutrients from straw to grain were significantly different between winter wheat (1.63–2.52 for Cu; 2.31–3.82 for Zn; no change for Fe; 0.55–0.84 for Mn) and summer maize (0.24–0.50 for Cu; 0.50–1.21 for Zn; 0.02–0.04 for Fe; 0.07–0.10 for Mn). In conclusion, application of organic matter significantly increased the DTPA-extractable concentrations of Zn, Fe and Mn compared to the CK, grain and vegetative tissue in the CK and NK had higher micronutrient concentrations than those in other treatments.