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Institution

Oregon State University

EducationCorvallis, Oregon, United States
About: Oregon State University is a education organization based out in Corvallis, Oregon, United States. It is known for research contribution in the topics: Population & Climate change. The organization has 28192 authors who have published 64044 publications receiving 2634108 citations. The organization is also known as: Oregon Agricultural College & OSU.


Papers
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Journal ArticleDOI
TL;DR: The HPO’s interoperability with other ontologies has enabled it to be used to improve diagnostic accuracy by incorporating model organism data and plays a key role in the popular Exomiser tool, which identifies potential disease-causing variants from whole-exome or whole-genome sequencing data.
Abstract: The Human Phenotype Ontology (HPO)-a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases-is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world. Its detailed descriptions of clinical abnormalities and computable disease definitions have made HPO the de facto standard for deep phenotyping in the field of rare disease. The HPO's interoperability with other ontologies has enabled it to be used to improve diagnostic accuracy by incorporating model organism data. It also plays a key role in the popular Exomiser tool, which identifies potential disease-causing variants from whole-exome or whole-genome sequencing data. Since the HPO was first introduced in 2008, its users have become both more numerous and more diverse. To meet these emerging needs, the project has added new content, language translations, mappings and computational tooling, as well as integrations with external community data. The HPO continues to collaborate with clinical adopters to improve specific areas of the ontology and extend standardized disease descriptions. The newly redesigned HPO website (www.human-phenotype-ontology.org) simplifies browsing terms and exploring clinical features, diseases, and human genes.

532 citations

Journal ArticleDOI
TL;DR: This paper shows how this method is based on the construction of the generalized inverse from the singular value decomposition of a set of CD spectra corresponding to proteins whose secondary structures are known from X-ray crystallography without resorting to least-squares fitting and standard matrix inversion techniques.

531 citations

Journal ArticleDOI
28 Jun 1991-Science
TL;DR: It appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior, and these binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya.
Abstract: Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.

531 citations

Journal ArticleDOI
TL;DR: In this paper, the authors developed a light use efficiency (LUE) daily GPP model from eddy covariance (EC) measurements, which is driven by only four variables: normalized difference vegetation index (NDVI), photosynthetically active radiation (PAR), air temperature, and the Bowen ratio of sensible to latent heat flux (used to calculate moisture stress).

529 citations


Authors

Showing all 28447 results

NameH-indexPapersCitations
Robert Stone1601756167901
Menachem Elimelech15754795285
Thomas J. Smith1401775113919
Harold A. Mooney135450100404
Jerry M. Melillo13438368894
John F. Thompson132142095894
Thomas N. Williams132114595109
Peter M. Vitousek12735296184
Steven W. Running12635576265
Vincenzo Di Marzo12665960240
J. D. Hansen12297576198
Peter Molnar11844653480
Michael R. Hoffmann10950063474
David Pollard10843839550
David J. Hill107136457746
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023105
2022375
20213,156
20203,109
20193,017
20182,987