Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Population. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Population, Catalysis, Thin film, Gene
Papers published on a yearly basis
Papers
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United States Naval Research Laboratory1, Brookhaven National Laboratory2, Space Sciences Laboratory3, Kingsborough Community College4, University of Münster5, Michigan State University6, Osaka University7, Jet Propulsion Laboratory8, Lawrence Livermore National Laboratory9, Kobe University10, European Synchrotron Radiation Facility11, Washington University in St. Louis12, University of Chicago13, École normale supérieure de Lyon14, University of New Mexico15, Kyushu University16, University of Tokyo17, University of Washington18, Lawrence Berkeley National Laboratory19, University of Jena20, University of Hawaii21, American Museum of Natural History22, Case Western Reserve University23, University of Hyogo24, United States Geological Survey25, Imperial College London26, State University of New York System27, Open University28, Stanford University29
TL;DR: The bulk of the comet 81P/Wild 2 samples returned to Earth by the Stardust spacecraft appear to be weakly constructed mixtures of nanometer-scale grains, with occasional much larger ferromagnesian silicates, Fe-Ni sulfides,Fe-Ni metal, and accessory phases.
Abstract: The bulk of the comet 81P/Wild 2 (hereafter Wild 2) samples returned to Earth by the Stardust spacecraft appear to be weakly constructed mixtures of nanometer-scale grains, with occasional much larger (over 1 micrometer) ferromagnesian silicates, Fe-Ni sulfides, Fe-Ni metal, and accessory phases. The very wide range of olivine and low-Ca pyroxene compositions in comet Wild 2 requires a wide range of formation conditions, probably reflecting very different formation locations in the protoplanetary disk. The restricted compositional ranges of Fe-Ni sulfides, the wide range for silicates, and the absence of hydrous phases indicate that comet Wild 2 experienced little or no aqueous alteration. Less abundant Wild 2 materials include a refractory particle, whose presence appears to require radial transport in the early protoplanetary disk.
644 citations
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TL;DR: It is demonstrated that macrophage inducible C-type lectin (Mincle) is an essential receptor for TDM, a mycobacterial cell wall glycolipid that is the most studied immunostimulatory component of M. tuberculosis.
Abstract: Tuberculosis remains a fatal disease caused by Mycobacterium tuberculosis, which contains various unique components that affect the host immune system. Trehalose-6,6'-dimycolate (TDM; also called cord factor) is a mycobacterial cell wall glycolipid that is the most studied immunostimulatory component of M. tuberculosis. Despite five decades of research on TDM, its host receptor has not been clearly identified. Here, we demonstrate that macrophage inducible C-type lectin (Mincle) is an essential receptor for TDM. Heat-killed mycobacteria activated Mincle-expressing cells, but the activity was lost upon delipidation of the bacteria; analysis of the lipid extracts identified TDM as a Mincle ligand. TDM activated macrophages to produce inflammatory cytokines and nitric oxide, which are completely suppressed in Mincle-deficient macrophages. In vivo TDM administration induced a robust elevation of inflammatory cytokines in sera and characteristic lung inflammation, such as granuloma formation. However, no TDM-induced lung granuloma was formed in Mincle-deficient mice. Whole mycobacteria were able to activate macrophages even in MyD88-deficient background, but the activation was significantly diminished in Mincle/MyD88 double-deficient macrophages. These results demonstrate that Mincle is an essential receptor for the mycobacterial glycolipid, TDM.
644 citations
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TL;DR: In this article, a virtual synchronous generator (VSG) with alternating moment of inertia (OMO) was proposed to enhance the response of the virtual machine in tracking the steady-state frequency.
Abstract: The virtual synchronous generator (VSG) is a control scheme applied to the inverter of a distributed generating unit to support power system stability by imitating the behavior of a synchronous machine. The VSG design of our research incorporates the swing equation of a synchronous machine to express a virtual inertia property. Unlike a real synchronous machine, the parameters of the swing equation of the VSG can be controlled in real time to enhance the fast response of the virtual machine in tracking the steady-state frequency. Based on this concept, the VSG with alternating moment of inertia is elaborated in this paper. The damping effect of the alternating inertia scheme is investigated by transient energy analysis. In addition, the performance of the proposed inertia control in stability of nearby machines in power system is addressed. The idea is supported by simulation and experimental results, which indicates remarkable performance in the fast damping of oscillations.
644 citations
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TL;DR: SOCS-1 is suggested as an essential, negative regulator in LPS responses that protects the host from harmful overresponses to LPS and may provide new insight into the endotoxin-induced fatal syndrome that occasionally occurs following infection.
644 citations
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TL;DR: Although the developers of the Positive and Negative Syndrome Scale (PANSS) grouped items into three subscales, factor analyses indicate that a five-factor model better characterizes PANSS data, but lack of consensus on which model to use limits the comparability of PANSS variables across studies.
643 citations
Authors
Showing all 84130 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
Thomas C. Südhof | 191 | 653 | 118007 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Yusuke Nakamura | 179 | 2076 | 160313 |
H. S. Chen | 179 | 2401 | 178529 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Kenji Kangawa | 153 | 1117 | 110059 |
Jongmin Lee | 150 | 2257 | 134772 |
Yoshio Bando | 147 | 1234 | 80883 |
Takeo Kanade | 147 | 799 | 103237 |
Olaf Reimer | 144 | 716 | 74359 |
Yuji Matsuzawa | 143 | 836 | 116711 |
Kim Nasmyth | 142 | 294 | 59231 |
Tasuku Honjo | 141 | 712 | 88428 |