scispace - formally typeset
Search or ask a question
Institution

Osaka University

EducationOsaka, Japan
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Population. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Population, Catalysis, Thin film, Gene


Papers
More filters
Journal ArticleDOI
Shizuo Akira1
TL;DR: Toll-like receptors are essential in the host defense against microbial pathogens and evoke inflammatory responses and the molecular mechanisms by which TLRs induce differential gene expression are now beginning to be clarified.

625 citations

Journal ArticleDOI
TL;DR: A biweekly 8 mg/kg infusion of MRA was well tolerated, normalized the acute-phase responses, and suggests a clinical effect in active Crohn's disease.

625 citations

Journal ArticleDOI
TL;DR: Sublobar resection should be considered as an alternative for stage IA non-small cell lung cancers 2 cm or less, even in low-risk patients, and could lay the foundation for starting randomized controlled trials anew.

624 citations

Journal ArticleDOI
TL;DR: In this paper, the authors showed that nanoparticles with diameters of 70 nm and 35 nm can cause pregnancy complications when injected intravenously into pregnant mice, and that these detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups.
Abstract: The increasing use of nanomaterials has raised concerns about their potential risks to human health Recent studies have shown that nanoparticles can cross the placenta barrier in pregnant mice and cause neurotoxicity in their offspring, but a more detailed understanding of the effects of nanoparticles on pregnant animals remains elusive Here, we show that silica and titanium dioxide nanoparticles with diameters of 70 nm and 35 nm, respectively, can cause pregnancy complications when injected intravenously into pregnant mice The silica and titanium dioxide nanoparticles were found in the placenta, fetal liver and fetal brain Mice treated with these nanoparticles had smaller uteri and smaller fetuses than untreated controls Fullerene molecules and larger (300 and 1,000 nm) silica particles did not induce these complications These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups

624 citations

Journal ArticleDOI
12 Jan 2012-Nature
TL;DR: It is concluded that stars are orbited by planets as a rule, rather than the exception, and that of stars host Jupiter-mass planets 0.5–10 au (Sun–Earth distance) from their stars.
Abstract: Most known extrasolar planets (exoplanets) have been discovered using the radial velocity or transit methods. Both are biased towards planets that are relatively close to their parent stars, and studies find that around 17–30% of solar-like stars host a planet. Gravitational microlensing on the other hand, probes planets that are further away from their stars. Recently, a population of planets that are unbound or very far from their stars was discovered by microlensing. These planets are at least as numerous as the stars in the Milky Way. Here we report a statistical analysis of microlensing data (gathered in 2002–07) that reveals the fraction of bound planets 0.5–10 au (Sun–Earth distance) from their stars. We find that 17^(+16)_(-9)% of stars host Jupiter-mass planets (0.3–10 M_J, where M_J = 318 M_⊕ plus and M_⊕ plus is Earth’s mass). Cool Neptunes (10–30 M_⊕ plus) and super-Earths (5–10 M_⊕ plus) are even more common: their respective abundances per star are 52^(+22)_(-29)% and 62^(+35)_(-73)% . We conclude that stars are orbited by planets as a rule, rather than the exception.

623 citations


Authors

Showing all 84130 results

NameH-indexPapersCitations
Shizuo Akira2611308320561
Thomas C. Südhof191653118007
Tadamitsu Kishimoto1811067130860
Yusuke Nakamura1792076160313
H. S. Chen1792401178529
Hyun-Chul Kim1764076183227
Masayuki Yamamoto1711576123028
Kenji Kangawa1531117110059
Jongmin Lee1502257134772
Yoshio Bando147123480883
Takeo Kanade147799103237
Olaf Reimer14471674359
Yuji Matsuzawa143836116711
Kim Nasmyth14229459231
Tasuku Honjo14171288428
Network Information
Related Institutions (5)
Kyoto University
217.2K papers, 6.5M citations

97% related

Nagoya University
128.2K papers, 3.2M citations

97% related

University of Tokyo
337.5K papers, 10.1M citations

97% related

Tohoku University
170.7K papers, 3.9M citations

97% related

University of Tsukuba
79.4K papers, 1.9M citations

97% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023139
2022637
20216,914
20206,865
20196,462
20186,189