Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Population. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Population, Catalysis, Thin film, Gene
Papers published on a yearly basis
Papers
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TL;DR: Loss of signal-transducing ability of gp130 with such a mutation coincided with disappearance of IL-6-induced tyrosine phosphorylation ofgp130, and the mutant cDNAs were transfected into murine interleukin 3-dependent cells to determine amino acid residues critical for generating the IL- 6-mediated growth signal.
Abstract: Interleukin 6 (IL-6) signal is transduced through gp130 that associates with a complex of IL-6 and IL-6 receptor. Truncations or amino acid substitutions offe introduced in the cytoplasmic region of human gp130, and the mutant cDNAs were transfected into murine interleukin 3-dependent cells to determine amino acid residues critical for generating the IL-6-mediated growth signal. In the 277-amino acid cytoplasmic region of gp130, a 61-amino acid region proximal to the transmembrane domain was sufficient for generating the growth signal. In this region, two short segments were significantly homologous with other cytokine-receptor family members. One segment is conserved in almost all members of the family, and the other is found especially in granulocyte colony-stimulating factor receptor, interleukin 2 receptor beta chain, erythropoietin receptor, KH97 (a granulocyte/macrophage colony-stimulating factor receptor-associated molecule), and interleukin 3 receptor. gp130 molecules with mutations in either of these two segments could not transduce growth signal. Loss of signal-transducing ability of gp130 with such a mutation coincided with disappearance of IL-6-induced tyrosine phosphorylation of gp130.
567 citations
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TL;DR: Patients generating patient-specific induced pluripotent stem cell cardiomyocytes from a ten-member family cohort carrying a hereditary HCM missense mutation (Arg663His) in the MYH7 gene are generated to help elucidate the mechanisms underlying HCM development and identify novel therapies for the disease.
567 citations
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Academic Center for Dentistry Amsterdam1, University of Helsinki2, New York University3, University of Missouri–Kansas City4, Osaka University5, Tel Aviv University6, Katholieke Universiteit Leuven7, University of Kentucky8, Kyushu University9, Université de Montréal10, Karolinska Institutet11, Aarhus University12, University of Siena13
TL;DR: There is a need for an updated consensus on a definition of bruxism as repetitive masticatory muscle activity characterised by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible to be confirmed.
Abstract: In 2013, consensus was obtained on a definition of bruxism as repetitive masticatory muscle activity characterised by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible and specified as either sleep bruxism or awake bruxism. In addition, a grading system was proposed to determine the likelihood that a certain assessment of bruxism actually yields a valid outcome. This study discusses the need for an updated consensus and has the following aims: (i) to further clarify the 2013 definition and to develop separate definitions for sleep and awake bruxism; (ii) to determine whether bruxism is a disorder rather than a behaviour that can be a risk factor for certain clinical conditions; (iii) to re-examine the 2013 grading system; and (iv) to develop a research agenda. It was concluded that: (i) sleep and awake bruxism are masticatory muscle activities that occur during sleep (characterised as rhythmic or non-rhythmic) and wakefulness (characterised by repetitive or sustained tooth contact and/or by bracing or thrusting of the mandible), respectively; (ii) in otherwise healthy individuals, bruxism should not be considered as a disorder, but rather as a behaviour that can be a risk (and/or protective) factor for certain clinical consequences; (iii) both non-instrumental approaches (notably self-report) and instrumental approaches (notably electromyography) can be employed to assess bruxism; and (iv) standard cut-off points for establishing the presence or absence of bruxism should not be used in otherwise healthy individuals; rather, bruxism-related masticatory muscle activities should be assessed in the behaviour's continuum.
566 citations
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TL;DR: In this paper, various kinds of new SPD mechanical properties of the ARB processed materials are indicated, and the authors show that the rolling in ARB is not only a deformation process but also a bonding process.
Abstract: Accumulative roll-Bonding (ARB) is a severe plastic deformation (SPD) process invented by the authors in order to fabricate ultrafine grained metallic materials. ARB is the only SPD process applicable to continuous production of bulky materials. In the process, 50 % rolled material is cut into two, stacked to be the initial dimension and then rolled again. In order to obtain one-body solid material, the rolling in ARB is not only a deformation process but also a bonding process (roll-bonding). By repeating this procedure, SPD of bulky materials can be realized. In this review paper, various kinds of new SPD mechanical properties of the ARB processed materials are indicated.
566 citations
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University of California, Irvine1, Oregon Health & Science University2, Merck & Co.3, University of Virginia4, Harvard University5, Thomas Jefferson University6, Yale University7, Astellas Pharma8, University of Wisconsin-Madison9, University of Ulm10, University of California, San Francisco11, University of Würzburg12, Rosalind Franklin University of Medicine and Science13, Vanderbilt University14, Osaka University15, Centre national de la recherche scientifique16, California Institute of Technology17, Stony Brook University18, Washington University in St. Louis19, King's College London20, New York University21, University of Utah22, Chiba University23, Max Planck Society24, Colorado State University25, University of California, Santa Barbara26, University of Tulsa27
TL;DR: An overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels as mentioned in this paper.
Abstract: This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels.1 The complete Compendium, including data tables for each member of the potassium channel family can be found at http://www.iuphar-db.org/iuphar-ic/.
566 citations
Authors
Showing all 84130 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
Thomas C. Südhof | 191 | 653 | 118007 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Yusuke Nakamura | 179 | 2076 | 160313 |
H. S. Chen | 179 | 2401 | 178529 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Kenji Kangawa | 153 | 1117 | 110059 |
Jongmin Lee | 150 | 2257 | 134772 |
Yoshio Bando | 147 | 1234 | 80883 |
Takeo Kanade | 147 | 799 | 103237 |
Olaf Reimer | 144 | 716 | 74359 |
Yuji Matsuzawa | 143 | 836 | 116711 |
Kim Nasmyth | 142 | 294 | 59231 |
Tasuku Honjo | 141 | 712 | 88428 |