Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Population. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Population, Catalysis, Thin film, Gene
Papers published on a yearly basis
Papers
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TL;DR: A transgenic mouse line carrying the CAG-cre transgene in which the cre gene is under control of the cytomegalovirus immediate early enhancer-chicken beta-actin hybrid (CAG) promoter is developed, and Cre mRNA and/or protein are retained in mature oocytes irrespective of the transmission of the C AG-cre Transgene, resulting in efficient Cre-mediated recombination of paternally derived target genes upon fertilization.
512 citations
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Osaka University1, University of Tsukuba2, University of the Ryukyus3, Sapporo Medical University4, Kyushu University5, Fukushima Medical University6, Jichi Medical University7, Niigata University8, Nagoya University9, Tohoku University10, Okayama University11, Hamamatsu University School of Medicine12
TL;DR: Although the Japanese coefficient improves the accuracy of G FR estimation of the original MDRD study equation, a new equation is needed for more accurate estimation of GFR in Japanese patients with CKD stages 3 and 4.
Abstract: Background
Accurate estimation of the glomerular filtration rate (GFR) is crucial for the detection of chronic kidney disease (CKD). In clinical practice, GFR is estimated from serum creatinine using the Modification of Diet in Renal Disease (MDRD) study equation or the Cockcroft-Gault (CG) equation instead of the time-consuming method of measured clearance for exogenous markers such as inulin. In the present study, the equations originally developed for a Caucasian population were tested in Japanese CKD patients, and modified with the Japanese coefficient determined by the data.
511 citations
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TL;DR: The synthesis and functions of a polyphenylene-based conjugated microporous polymer (PP-CMP), recently designed and synthesized by Suzuki polycondensation reaction, are described, which demonstrates the usefulness of CMPs in the exploration of pi-electronic functions, in addition to their gas adsorption properties thus far reported.
Abstract: The molecular design of light-harvesting antennae requires not only the segregation of a large number of chromophore units in a confined nanospace but also the cooperation of these units in achieving highly efficient energy transduction. This article describes the synthesis and functions of a polyphenylene-based conjugated microporous polymer (PP-CMP). PP-CMP was recently designed and synthesized by Suzuki polycondensation reaction and used as an antenna for the noncovalent construction of a light-harvesting system. In contrast to linear polyphenylene, PP-CMP consists of conjugated three-dimensional polyphenylene scaffolds and holds inherent porous structure with uniform pore size (1.56 nm) and large surface area (1083 m2 g−1). It emits blue photoluminescence, is capable of excitation energy migration over the framework, and enables rapid transportation of charge carrier with intrinsic mobility as high as 0.04 cm2 V−1 s−1. The microporous structure of PP-CMP allows for the spatial confinement of energy-ac...
511 citations
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TL;DR: Data is presented that suggest that YF-17D activates multiple Toll-like receptors on dendritic cells (DCs) to elicit a broad spectrum of innate and adaptive immune responses, and highlights the potential of vaccination strategies that use combinations of different TLR ligands to stimulate polyvalent immune responses.
Abstract: The live attenuated yellow fever vaccine 17D (YF-17D) is one of the most effective vaccines available, with a 65-yr history of use in >400 million people globally. Despite this efficacy, there is presently no information about the immunological mechanisms by which YF-17D acts. Here, we present data that suggest that YF-17D activates multiple Toll-like receptors (TLRs) on dendritic cells (DCs) to elicit a broad spectrum of innate and adaptive immune responses. Specifically, YF-17D activates multiple DC subsets via TLRs 2, 7, 8, and 9 to elicit the proinflammatory cytokines interleukin (IL)-12p40, IL-6, and interferon-α. Interestingly, the resulting adaptive immune responses are characterized by a mixed T helper cell (Th)1/Th2 cytokine profile and antigen-specific CD8+ T cells. Furthermore, distinct TLRs appear to differentially control the Th1/Th2 balance; thus, whilst MyD88-deficient mice show a profound impairment of Th1 cytokines, TLR2-deficient mice show greatly enhanced Th1 and Tc1 responses to YF-17D. Together, these data enhance our understanding of the molecular mechanism of action of YF-17D, and highlight the potential of vaccination strategies that use combinations of different TLR ligands to stimulate polyvalent immune responses.
511 citations
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TL;DR: In this paper, a chiral unitary approach for meson-baryon interactions was used to generate two octets of J π = 1/2 − baryon states, which are degenerate in the limit of exact SU(3) symmetry, and a singlet.
510 citations
Authors
Showing all 84130 results
Name | H-index | Papers | Citations |
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Shizuo Akira | 261 | 1308 | 320561 |
Thomas C. Südhof | 191 | 653 | 118007 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Yusuke Nakamura | 179 | 2076 | 160313 |
H. S. Chen | 179 | 2401 | 178529 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Kenji Kangawa | 153 | 1117 | 110059 |
Jongmin Lee | 150 | 2257 | 134772 |
Yoshio Bando | 147 | 1234 | 80883 |
Takeo Kanade | 147 | 799 | 103237 |
Olaf Reimer | 144 | 716 | 74359 |
Yuji Matsuzawa | 143 | 836 | 116711 |
Kim Nasmyth | 142 | 294 | 59231 |
Tasuku Honjo | 141 | 712 | 88428 |