Institution
Osaka University
Education•Osaka, Japan•
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Population. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Population, Catalysis, Thin film, Gene
Papers published on a yearly basis
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TL;DR: This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols.
Abstract: The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize specific structures of microorganisms. Among them, Toll-like receptors (TLRs) are capable of sensing organisms ranging from bacteria to fungi, protozoa, and viruses, and play a major role in innate immunity. However, TLRs recognize pathogens either on the cell surface or in the lysosome/endosome compartment. Recently, cytoplasmic PRRs have been identified to detect pathogens that have invaded cytosols. In this review, we focus on the functions of PRRs in innate immunity and their downstream signaling cascades.
2,049 citations
15 Apr 2010
TL;DR: Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
Abstract: The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
2,041 citations
TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.
2,018 citations
TL;DR: In this paper, Cundall's Distinct Element Method (P.A.Cundall and O.L. Strack, 1979) is used to model contact forces between particles.
2,015 citations
TL;DR: The dissection of FoxP3(+) cells into subsets enables one to analyze Treg cell differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP 3(+) subpopulations.
1,979 citations
Authors
Showing all 84130 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Shizuo Akira | 261 | 1308 | 320561 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Yusuke Nakamura | 179 | 2076 | 160313 |
| H. S. Chen | 179 | 2401 | 178529 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Yoshio Bando | 147 | 1234 | 80883 |
| Takeo Kanade | 147 | 799 | 103237 |
| Olaf Reimer | 144 | 716 | 74359 |
| Yuji Matsuzawa | 143 | 836 | 116711 |
| Kim Nasmyth | 142 | 294 | 59231 |
| Tasuku Honjo | 141 | 712 | 88428 |