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Institution

Osaka University

EducationOsaka, Japan
About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Population. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.
Topics: Laser, Population, Catalysis, Thin film, Gene


Papers
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Journal ArticleDOI
TL;DR: The tissue distribution of CSK was investigated and whether CSK could phosphorylate the negative regulatory sites of src family kinases other than p60c-src was examined, raising the possibility that CSK might act as a universal regulator for src family Kinases.

491 citations

Journal ArticleDOI
TL;DR: It is shown that overexpression of an inactive mutant of Atg4B, a protease that processes pro-LC3 paralogues, inhibits autophagic degradation and lipidation of LC3Paralogues in mammalian cells.
Abstract: In the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes In mammalian cells, the existence of multiple Atg8 homologues (referred to as LC3 paralogues) has hampered genetic analysis of the lipidation of LC3 paralogues Here, we show that overexpression of an inactive mutant of Atg4B, a protease that processes pro-LC3 paralogues, inhibits autophagic degradation and lipidation of LC3 paralogues Inhibition was caused by sequestration of free LC3 paralogues in stable complexes with the Atg4B mutant In mutant overexpressing cells, Atg5- and ULK1-positive intermediate autophagic structures accumulated The length of these membrane structures was comparable to that in control cells; however, a significant number were not closed These results show that the lipidation of LC3 paralogues is involved in the completion of autophagosome formation in mammalian cells This study also provides a powerful tool for a wide variety of studies of autophagy in the future

491 citations

Journal ArticleDOI
TL;DR: Graphene, a two-dimensional layer of sp(2)-hybridized carbon atoms, can be viewed as a sheet of benzene rings fused together, leading to an entire family of phenalenyl derivatives--'open-shell graphene fragments'--that are of substantial interest from the standpoint of fundamental science as well as in view of their potential applications in materials chemistry, in particular quantum electronic devices.
Abstract: Graphene, a two-dimensional layer of sp(2)-hybridized carbon atoms, can be viewed as a sheet of benzene rings fused together. Three benzene rings can be combined in three different ways, to yield linear anthracene and angular phenanthrene, where the rings share two C-C bonds, and the phenalenyl structure where three C-C bonds are shared between the rings. This third structure contains an uneven number of carbon atoms and, hence, in its neutral state, an uneven number of electrons--that is, it is a radical. All three structures may be viewed as being sections of graphene. Extension of this concept leads to an entire family of phenalenyl derivatives--'open-shell graphene fragments'--that are of substantial interest from the standpoint of fundamental science as well as in view of their potential applications in materials chemistry, in particular quantum electronic devices. Here we discuss current trends and challenges in this field.

490 citations

Journal ArticleDOI
17 Jun 1994-Cell
TL;DR: It is reported that embryonic fibroblasts from mice with a null mutation in the IRF-1 gene can be transformed by expression of an activated c-Ha-ras oncogene and could be a critical determinant of oncogen-induced cell transformation or apoptosis.

490 citations

Journal ArticleDOI
TL;DR: It is demonstrated that aryl hydrocarbon receptor (Ahr) has an important regulatory function in the commitment of Th17 cells and participates in Th17 cell differentiation through regulating Stat1 activation, a finding that constitutes additional mechanisms in the modulation of Th 17 cell development.
Abstract: IL-17-producing T helper cells (Th17) have been recently identified as a previously undescribed subset of helper T cells. Here, we demonstrate that aryl hydrocarbon receptor (Ahr) has an important regulatory function in the commitment of Th17 cells. Ahr was robustly induced under Th17-polarizing conditions. Ahr-deficient naive T cells showed a considerable loss in the ability to differentiate into Th17 cells when induced by TGF-β plus IL-6. We were able to demonstrate that Ahr interacts with Stat1 and Stat5, which negatively regulate Th17 development. Whereas Stat1 activation returned to its basal level in Ahr wild type naive T cells 24 h after stimulation with TGF-β plus IL-6, Stat1 remained activated in Ahr-deficient naive T cells after stimulation. These results indicate that Ahr participates in Th17 cell differentiation through regulating Stat1 activation, a finding that constitutes additional mechanisms in the modulation of Th17 cell development.

489 citations


Authors

Showing all 84130 results

NameH-indexPapersCitations
Shizuo Akira2611308320561
Thomas C. Südhof191653118007
Tadamitsu Kishimoto1811067130860
Yusuke Nakamura1792076160313
H. S. Chen1792401178529
Hyun-Chul Kim1764076183227
Masayuki Yamamoto1711576123028
Kenji Kangawa1531117110059
Jongmin Lee1502257134772
Yoshio Bando147123480883
Takeo Kanade147799103237
Olaf Reimer14471674359
Yuji Matsuzawa143836116711
Kim Nasmyth14229459231
Tasuku Honjo14171288428
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023139
2022637
20216,914
20206,865
20196,462
20186,189