Osaka University

About: Osaka University is a education organization based out in Osaka, Japan. It is known for research contribution in the topics: Laser & Catalysis. The organization has 83778 authors who have published 185669 publications receiving 5158122 citations. The organization is also known as: Ōsaka daigaku.

Toll-like receptor function and signaling.

Abstract: Mammals sense pathogen invasion through pattern-recognition receptors. A group of transmembrane proteins, Toll-like receptors (TLRs), play critical roles as pattern-recognition receptors. They are mainly expressed on antigen-presenting cells, such as macrophages or dendritic cells, and their signaling activates antigen-presenting cells to provoke innate immunity and to establish adaptive immunity. Each TLR has common effects, such as inflammatory cytokine induction or upregulation of costimulatory molecule expression, but also has its specific function, exemplified by type I IFN-inducing ability. These immunoadjuvant effects are not only critical in antimicrobial immunity but are also involved in manifestations of autoimmunity. Furthermore, some TLR agonists are now promising therapeutic tools for various immune disorders, including allergy. Therefore understanding molecular mechanisms on TLRs should be quite useful in the development of therapeutic maneuvers against allergy and autoimmune diseases.

Regulatory T cells in tumor immunity

Abstract: Recent studies have revealed that Foxp3(+)CD25(+)CD4(+) regulatory T cells (Tregs), which are physiologically engaged in the maintenance of immunological self-tolerance, play critical roles for the control of antitumor immune responses. For example, a large number of Foxp3(+)Tregs infiltrate into tumors, and systemic removal of Foxp3(+)Tregs enhances natural as well as vaccine-induced antitumor T-cell responses. Tregs are recruited to tumor tissues via chemokines, such as CCL22 binding to CCR4 expressed by Tregs. They appear to expand and become activated in tumor tissues and in the draining lymph nodes by recognizing tumor-associated antigens as well as normal self-antigen expressed by tumor cells. These results indicate that cancer vaccines targeting tumor-associated self-antigens may potentially expand/activate Tregs and hamper effective antitumor immune responses, and that tumor immunity can therefore be enhanced by depleting Tregs, attenuating Treg suppressive function, or rendering effector T cells refractory to Treg-mediated suppression. Recent attempts have indeed demonstrated that combinations of monoclonal antibodies capable of modulating Treg functions synergistically enhance antitumor activity and are more effective than a single monoclonal antibody therapy. Combination therapy targeting a variety of molecules expressed in antigen-presenting cells, effector T cells and Tregs is envisaged to be a promising anticancer immunotherapy.

RoboCup: The Robot World Cup Initiative

Abstract: The Robot World Cup Initiative (R, oboCup) is attempt to foster AI and intelligent rohoties research by providing a standard problem where wide range of technologies especially concerning multi-agent research (:an be integrated and examined. The first RoboCup competition is to be, heht at. IJCAI-97, Nagoya. In order for a robot team to actually perform a soccer game. various technologies must I)e incorl)orated including: design principles of autononmus agents, multi-agent collaboration, strategy acquisition, real-time rea.~oning, robotics, and sensor-fllsion. Unlike AAAI robot competition, which is tuned for a single heavy-duty slow-moving robot. RoboCup is a task for a team of multiple f‘ast-moving robots under a dynamic environmen(. Although RoboCnp’s final target is a worhl cup with real robots, RoboCup offers a soft.ware platform for reseaxch on the software aspects of RoboCup. This paper describes teclini(’M challenges involw~d in RoboCup, rules, and simulation environment.