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Institution

Oswaldo Cruz Foundation

FacilityRio de Janeiro, Brazil
About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.


Papers
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Journal ArticleDOI
TL;DR: A summary of the most relevant facts concerning to the control of human Chagas disease, since its discovery and according to the consensus of the majority of theauthors, is presented.
Abstract: SUMMARY OF THE PRINCIPAL EVENTS RELATEDTO HUMAN CHAGAS DISEASE CONTROL FROM1909 TO 1999 In order to have a general and chronologic com-prehension of the facts appointed above, the fol-lowing picture was prepared, showing the consid-ered most relevant facts concerning to the controlof human Chagas disease, since its discovery andaccording to the consensus of the majority of theauthors (Dias 1988, Coura 1997, Schofield & Dias1999): YEARS SUBJECT/OBSERVATION 1909 Carlos Chagas discovers the disease1911 Chagas proposes vector control andhousing improvement and describes thecongenital transmission of Trypanono-ma cruzi1913 Brumpt describes xenodiagnosis;Guerreiro and Machado develop comple-ment fixation test1916 Chagas emphasizes chronic heart disease1918 Souza Araujo promotes a law con-cern ing house improvement in endemicareas1919-22 N Larrier and S Campos study congenit-al transmission at experimental level1926 Mazza begins the MEPRA project inJujuy, Argentina1930-34 C Chagas and E Chagas employ EKG inchronic Chagas heart disease1932-36 Mazza claims for housing improvementand tries some classical drugs in Chagasdisease1935 IX MEPRA meeting; Romana describeshis eye portal of entry sign1935-44 Many acute cases are described in Ar-gentina, Brazil, Uruguay and Venezuela.Mazza warns about the risk of transfu-sion and oral (mother milk) transmission1943 Foundation of the Bambui center inMinas Gerais, Brazil, by EmmanuelDias, where trials are made of severalavailable insecticides (including cya-nidegas), physical methods (flame-thrower), housing improvement andcommunity participation1944-46 Still in Bambui, beginning of chronic car-diopathy systematization; failure of DDTagainst triatomines; Dias warns againstthe risk of transfusion disease1947-48 First laboratory trials against insects(Busvine & Barnes 1947) and descrip-tion of the action of HCH (gammexane)against triatomines (Dias & Pellegrino,Romana & Abalos); first large scale sur-vey employing serology and EKG innon-selected population (Bambui)1949 First regional serological survey of blooddonors (Pellegrino, in Belo Horizonte,Brazil); L Dao confirms in Venezuela thecongenital transmission of humanChagas disease; Ramos and Freitas carryon a serological and EKG inquiry inCassia dos Coqueiros, SP, Brazil1950-52 In Sao Paulo, Brazil, Nussensweig,Freitas and Amato Neto confirm trans-fusional transmitted Chagas disease. Thesame group employs successfully gen-tian violet as chemoprophylactic agentin blood banks. First large-scale trial withgammexane against triatomines inUberaba, Minas Gerais, Brazil (E Dias,Bustamante et al.)1955 First experimental trial attempting Tri-atoma infestans eradication in Bambui(E Dias)1956 Publication of the definitive systemati-zation of chronic heart Chagas diseasein Circulation by Laranja, Dias, Nobregaand Miranda1957-58 Re-description of Chagas disease diges-tive forms by Koberle and others. Im-portant serological and EKG survey inthe Cordoba region of Argentina, byRosenbaum and Cerisola. Important re-gional epidemiological surveys in Ven-ezuela, by Pifano et al.1959 Neghme and Schenone confirm in Chilethe results obtained in Bambui againstT. infestans . E Dias emphasises the con-cept of T. infestans eradication1960-70 Beginning of vector control in Sao Paulo,Brazil, and in Venezuela (NationalProgramme: using insecticide plus hous-

154 citations

Journal ArticleDOI
01 Feb 2003-Urology
TL;DR: The incidence of erectile dysfunction in Brazilian men was 2.5-fold higher than that in the Massachusetts Male Aging Study and increased with age, lower education, diabetes, hypertension, and benign prostatic hyperplasia.

154 citations

Journal ArticleDOI
TL;DR: The findings demonstrate that administration of curcumin was effective in preventing behavioral impairments, neuroinflammation, tau hyperphosphorylation as well as cell signaling disturbances triggered by Aβ in vivo, and suggest thatCur-LNC in a dose 20-fold lower presented similar neuroprotective results compared to the effective dose of free curcuming.

154 citations

Journal ArticleDOI
TL;DR: The current conventional diagnostic tools, such as complement fixation and immunodiffusion, are reviewed, the development of novel diagnostic reagents and methods are outlined, and their relative merits and disadvantages are discussed to the immunodiagnostic of this mycosis.

154 citations

Journal ArticleDOI
TL;DR: Experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages are discussed, and comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages.
Abstract: Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation, turnover of macromolecules and organelles, and defense against parasitic invaders. During the last 10-20 years, molecular components of the autophagic machinery have been discovered, revealing a complex interactome of proteins and lipids, which, in a concerted way, induce membrane formation to engulf cellular material and target it for lysosomal degradation. Here, our emphasis is autophagy in protists. We discuss experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages. Moreover, we describe how comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages, most probably as a consequence of diverse lifestyle adaptations. We also review experimental studies illustrating how several pathogenic protists either utilize autophagy mechanisms or manipulate host-cell autophagy in order to establish or maintain infection within a host. The essentiality of autophagy for the pathogenicity of many parasites, and the unique features of some of the autophagy-related proteins involved, suggest possible new targets for drug discovery. Further studies of the molecular details of autophagy in protists will undoubtedly enhance our understanding of the diversity and complexity of this cellular phenomenon and the opportunities it offers as a drug target.

153 citations


Authors

Showing all 18833 results

NameH-indexPapersCitations
Douglas T. Golenbock12331761267
Guy A. Zimmerman10932839740
David Brown105125746827
Liam Smeeth10475353433
Ann M. Dvorak9943741073
David C. Spray9540028732
Theodore A. Slotkin8957530070
Fernando Q. Cunha8868231501
Mauro M. Teixeira8671331301
Ricardo T. Gazzinelli8634028233
Peter F. Weller8533122005
João B. Calixto8146023029
Frederic J. Seidler8037219564
João Santana da Silva8039919060
Deborah Carvalho Malta7770661000
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202334
2022250
20212,842
20202,942
20192,404
20182,302