Institution
Oswaldo Cruz Foundation
Facility•Rio de Janeiro, Brazil•
About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.
Topics: Population, Trypanosoma cruzi, Immune system, Leishmania, Health care
Papers published on a yearly basis
Papers
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TL;DR: The combination of the IgM and IgG ELISAs may be used to serologically diagnose dengue virus infections, since the IgGELISA can substitute for the HI test in characterizing the immune response to dengu virus infections.
142 citations
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TL;DR: Comparison of the compositions of oleoresins from Copaifera guianensis Desf.
142 citations
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TL;DR: The finding of an increased capillary density in effectively treated antihypertensives suggests that a cause-to-effect relationship between BP and capillarydensity should be evaluated in a long-term prospective follow-up.
142 citations
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TL;DR: The results indicate problematic nutritional status in the Brazilian elderly, particularly women.
Abstract: This paper presents the nutritional status of the elderly Brazilian population (60 years and older) based on a probabilistic sample survey in 1989. Nutritional assessment used the BMI (kg/m2), with cut-off points recommended by the WHO (1995). Socio-demographic variables included age, gender, region and place of residence in the country (urban/rural area), income, education, and housing conditions. Prevalence rates for thinness (BMI < 18.5) and overweight (BMI ( 25) were 7.8% and 30.4% in men and 8.4% and 50.2% in women, higher than in the young adult population. Thinness was more frequent in older women, in rural areas from the Midwest/Northeast regions (women) and Southeast/Midwest (men), in groups with lower income, less schooling, and worse housing conditions. Overweight was more frequent in women from urban areas in the South and Southeast and groups with higher income, more schooling, and better housing conditions. The results indicate problematic nutritional status in the Brazilian elderly, particularly women.
142 citations
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University of New South Wales1, Oswaldo Cruz Foundation2, University of Cambridge3, Newcastle University4, Albert Einstein College of Medicine5, French Institute of Health and Medical Research6, University of Montpellier7, University of Edinburgh8, Columbia University9, National and Kapodistrian University of Athens10, Harokopio University11, University of Thessaly12, The Chinese University of Hong Kong13, Tai Po Hospital14, Seoul National University Bundang Hospital15, New Generation University College16, UPRRP College of Natural Sciences17, Yonsei University18, Australian National University19, University of São Paulo20, Kyushu University21, Central South University22, Fukuoka Institute of Technology23, National University of Singapore24, University of Zaragoza25, Ministry of Science and Innovation26
TL;DR: Cognitive performance declined with age, and more rapidly with increasing age, across samples from diverse ethnocultural groups and geographical regions, suggesting that different rates of cognitive decline might contribute to the global variation in dementia prevalence.
Abstract: BACKGROUND: The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related decline in cognitive test performance varied among international cohort studies of cognitive aging. We also determined the extent to which sex, educational attainment, and apolipoprotein E e4 allele (APOE*4) carrier status were associated with decline.
METHODS AND FINDINGS: We harmonized longitudinal data for 14 cohorts from 12 countries (Australia, Brazil, France, Greece, Hong Kong, Italy, Japan, Singapore, Spain, South Korea, United Kingdom, United States), for a total of 42,170 individuals aged 54-105 y (42% male), including 3.3% with dementia at baseline. The studies began between 1989 and 2011, with all but three ongoing, and each had 2-16 assessment waves (median = 3) and a follow-up duration of 2-15 y. We analyzed standardized Mini-Mental State Examination (MMSE) and memory, processing speed, language, and executive functioning test scores using linear mixed models, adjusted for sex and education, and meta-analytic techniques. Performance on all cognitive measures declined with age, with the most rapid rate of change pooled across cohorts a moderate -0.26 standard deviations per decade (SD/decade) (95% confidence interval [CI] [-0.35, -0.16], p < 0.001) for processing speed. Rates of decline accelerated slightly with age, with executive functioning showing the largest additional rate of decline with every further decade of age (-0.07 SD/decade, 95% CI [-0.10, -0.03], p = 0.002). There was a considerable degree of heterogeneity in the associations across cohorts, including a slightly faster decline (p = 0.021) on the MMSE for Asians (-0.20 SD/decade, 95% CI [-0.28, -0.12], p < 0.001) than for whites (-0.09 SD/decade, 95% CI [-0.16, -0.02], p = 0.009). Males declined on the MMSE at a slightly slower rate than females (difference = 0.023 SD/decade, 95% CI [0.011, 0.035], p < 0.001), and every additional year of education was associated with a rate of decline slightly slower for the MMSE (0.004 SD/decade less, 95% CI [0.002, 0.006], p = 0.001), but slightly faster for language (-0.007 SD/decade more, 95% CI [-0.011, -0.003], p = 0.001). APOE*4 carriers declined slightly more rapidly than non-carriers on most cognitive measures, with processing speed showing the greatest difference (-0.08 SD/decade, 95% CI [-0.15, -0.01], p = 0.019). The same overall pattern of results was found when analyses were repeated with baseline dementia cases excluded. We used only one test to represent cognitive domains, and though a prototypical one, we nevertheless urge caution in generalizing the results to domains rather than viewing them as test-specific associations. This study lacked cohorts from Africa, India, and mainland China.
CONCLUSIONS: Cognitive performance declined with age, and more rapidly with increasing age, across samples from diverse ethnocultural groups and geographical regions. Associations varied across cohorts, suggesting that different rates of cognitive decline might contribute to the global variation in dementia prevalence. However, the many similarities and consistent associations with education and APOE genotype indicate a need to explore how international differences in associations with other risk factors such as genetics, cardiovascular health, and lifestyle are involved. Future studies should attempt to use multiple tests for each cognitive domain and feature populations from ethnocultural groups and geographical regions for which we lacked data.
142 citations
Authors
Showing all 18833 results
Name | H-index | Papers | Citations |
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Douglas T. Golenbock | 123 | 317 | 61267 |
Guy A. Zimmerman | 109 | 328 | 39740 |
David Brown | 105 | 1257 | 46827 |
Liam Smeeth | 104 | 753 | 53433 |
Ann M. Dvorak | 99 | 437 | 41073 |
David C. Spray | 95 | 400 | 28732 |
Theodore A. Slotkin | 89 | 575 | 30070 |
Fernando Q. Cunha | 88 | 682 | 31501 |
Mauro M. Teixeira | 86 | 713 | 31301 |
Ricardo T. Gazzinelli | 86 | 340 | 28233 |
Peter F. Weller | 85 | 331 | 22005 |
João B. Calixto | 81 | 460 | 23029 |
Frederic J. Seidler | 80 | 372 | 19564 |
João Santana da Silva | 80 | 399 | 19060 |
Deborah Carvalho Malta | 77 | 706 | 61000 |