Institution
Oswaldo Cruz Foundation
Facility•Rio de Janeiro, Brazil•
About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.
Topics: Population, Trypanosoma cruzi, Immune system, Leishmania, Health care
Papers published on a yearly basis
Papers
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TL;DR: Variants in the regulatory region shared by PARK2 and PACRG act as common risk factors for leprosy by using a systematic association scan of the chromosomal interval most likely to harbour this leproSy susceptibility locus.
Abstract: Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year1. It has long been thought that leprosy has a strong genetic component2, and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25–q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy and 17 markers located in a block of approx. 80 kilobases overlapping the 5′ regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.
428 citations
TL;DR: In Latin America, health-system reforms have produced a distinct approach to universal health coverage, underpinned by the principles of equity, solidarity, and collective action to overcome social inequalities as discussed by the authors.
428 citations
TL;DR: In this paper, the authors use the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015.
427 citations
TL;DR: This Series paper raises the parallel question of whether discrimination based on gender likewise becomes embodied, with negative consequences for health, as well as how gender-biased health research and health-care systems reinforce and reproduce gender inequalities, with serious implications for health.
417 citations
TL;DR: Positive interactions between components of whole plant extracts may explain evidence that crude plant extracts often have greater in vitro or/and in vivo antiplasmodial activity than isolated constituents at an equivalent dose.
Abstract: Background
In traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. There is evidence that crude plant extracts often have greater in vitro or/and in vivo antiplasmodial activity than isolated constituents at an equivalent dose. The aim of this paper is to review positive interactions between components of whole plant extracts, which may explain this.
416 citations
Authors
Showing all 18833 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas T. Golenbock | 123 | 317 | 61267 |
| Guy A. Zimmerman | 109 | 328 | 39740 |
| David Brown | 105 | 1257 | 46827 |
| Liam Smeeth | 104 | 753 | 53433 |
| Ann M. Dvorak | 99 | 437 | 41073 |
| David C. Spray | 95 | 400 | 28732 |
| Theodore A. Slotkin | 89 | 575 | 30070 |
| Fernando Q. Cunha | 88 | 682 | 31501 |
| Mauro M. Teixeira | 86 | 713 | 31301 |
| Ricardo T. Gazzinelli | 86 | 340 | 28233 |
| Peter F. Weller | 85 | 331 | 22005 |
| João B. Calixto | 81 | 460 | 23029 |
| Frederic J. Seidler | 80 | 372 | 19564 |
| João Santana da Silva | 80 | 399 | 19060 |
| Deborah Carvalho Malta | 77 | 706 | 61000 |