Institution
Oswaldo Cruz Foundation
Facility•Rio de Janeiro, Brazil•
About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.
Topics: Population, Trypanosoma cruzi, Immune system, Leishmania, Health care
Papers published on a yearly basis
Papers
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TL;DR: It was verified that 19% of the animals' samples were above the limit recommended by WHO for human consumption, which refers to healthy adult, and data demonstrate that, although in low concentrations, there is already a contamination of fish and crustaceans from Sepetiba Bay.
255 citations
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TL;DR: This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities and approved pyrazole-containing drugs.
254 citations
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University of São Paulo1, Sao Paulo State University2, Federal University of São Paulo3, Federal University of Paraná4, Federal University of Mato Grosso do Sul5, Oswaldo Cruz Foundation6, Federal University of Uberlandia7, Translational Genomics Research Institute8, State University of Campinas9, Universidade Federal de Mato Grosso10
TL;DR: The present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management and emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression.
Abstract: Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P. lutzii ), has been reported in Rondonia, where the disease has reached epidemic levels, and in the Central West and Para. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.
252 citations
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TL;DR: It is demonstrated that ZIKV was circulating in Rio de Janeiro as early as January 2015, and pruritus, the second most common clinical sign presented by the confirmed cases, should be added to the PAHO case definition, while fever could be given less emphasis.
Abstract: Background
In 2015, Brazil was faced with the cocirculation of three arboviruses of major public health importance. The emergence of Zika virus (ZIKV) presents new challenges to both clinicians and public health authorities. Overlapping clinical features between diseases caused by
ZIKV, Dengue (DENV) and Chikungunya (CHIKV) and the lack of validated serological
assays for ZIKV make accurate diagnosis difficult.
Methodology / Principal Findings
The outpatient service for acute febrile illnesses in Fiocruz initiated a syndromic clinical observational study in 2007 to capture unusual presentations of DENV infections. In January
2015, an increase of cases with exanthematic disease was observed. Trained physicians
evaluated the patients using a detailed case report form that included clinical
assessment and laboratory investigations. The laboratory diagnostic algorithm included
assays for detection of ZIKV, CHIKV and DENV. 364 suspected cases of Zika virus disease
were identified based on clinical criteria between January and July 2015. Of these, 262
(71.9%) were tested and 119 (45.4%) were confirmed by the detection of ZIKV RNA. All of
the samples with sequence information available clustered within the Asian genotype. Conclusions / Significance
This is the first report of a ZIKV outbreak in the state of Rio de Janeiro, based on a large
number of suspected (n = 364) and laboratory confirmed cases (n = 119). We were able to
demonstrate that ZIKV was circulating in Rio de Janeiro as early as January 2015. The
peak of the outbreak was documented in May/June 2015. More than half of the patients
reported headache, arthralgia, myalgia, non-purulent conjunctivitis, and lower back pain,
consistent with the case definition of suspected ZIKV disease issued by the Pan American
Health Organization (PAHO). However, fever, when present, was low-intensity and shorttermed.
In our opinion, pruritus, the second most common clinical sign presented by the
confirmed cases, should be added to the PAHO case definition, while fever could be given
less emphasis. The emergence of ZIKV as a new pathogen for Brazil in 2015 underscores
the need for clinical vigilance and strong epidemiological and laboratory surveillance.
252 citations
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TL;DR: Different clinical presentations of vivax malaria infection present strong association with activation of pro-inflammatory responses and cytokine imbalance, which is of utmost importance to improve current knowledge about physiopathological concepts of this serious widespread disease.
Abstract: Despite clinical descriptions of severe vivax malaria cases having been reported, data regarding immunological and inflammatory patterns are scarce. In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease. Active and passive malaria case detections were performed during 2007 in Buritis, Rondonia, in the Brazilian Amazon. A total of 219 participants enrolled the study. Study individuals were classified according to the presence of Plasmodium vivax infection within four groups: non-infected (n = 90), asymptomatic (n = 60), mild (n = 50) and severe vivax infection (n = 19). A diagnosis of malaria was made by microscopy and molecular assays. Since at present no clear criteria define severe vivax malaria, this study adapted the consensual criteria from falciparum malaria. Patients with severe P. vivax infection were younger, had lived for shorter time in the endemic area, and recalled having experienced less previous malaria episodes than individuals with no malaria infection and with mild or asymptomatic infection. Strong linear trends were identified regarding increasing plasma levels of C reactive protein (CRP), serum creatinine, bilirubins and the graduation of disease severity. Plasma levels of tumour necrosis factor (TNF), interferon-gamma(IFN-gamma) and also IFN-gamma/interleukin-10 ratios were increased and exhibited a linear trend with gradual augmentation of disease severity. Both laboratory parameters of organ dysfunction and inflammatory cytokines were reduced during anti-parasite therapy in those patients with severe disease. Different clinical presentations of vivax malaria infection present strong association with activation of pro-inflammatory responses and cytokine imbalance. These findings are of utmost importance to improve current knowledge about physiopathological concepts of this serious widespread disease.
251 citations
Authors
Showing all 18833 results
Name | H-index | Papers | Citations |
---|---|---|---|
Douglas T. Golenbock | 123 | 317 | 61267 |
Guy A. Zimmerman | 109 | 328 | 39740 |
David Brown | 105 | 1257 | 46827 |
Liam Smeeth | 104 | 753 | 53433 |
Ann M. Dvorak | 99 | 437 | 41073 |
David C. Spray | 95 | 400 | 28732 |
Theodore A. Slotkin | 89 | 575 | 30070 |
Fernando Q. Cunha | 88 | 682 | 31501 |
Mauro M. Teixeira | 86 | 713 | 31301 |
Ricardo T. Gazzinelli | 86 | 340 | 28233 |
Peter F. Weller | 85 | 331 | 22005 |
João B. Calixto | 81 | 460 | 23029 |
Frederic J. Seidler | 80 | 372 | 19564 |
João Santana da Silva | 80 | 399 | 19060 |
Deborah Carvalho Malta | 77 | 706 | 61000 |