Oswaldo Cruz Foundation

About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.

Enfermedades crónica no transmisibles en Brasil: prioridad para enfrentar e investigar

Abstract: Las enfermedades cronicas no transmisibles representan la mayor carga de morbimortalidad en Brasil. En 2011, el Ministerio de Salud Brasileno lanzo un Plan de Acciones Estrategicas para Enfrentar las enfermedades cronicas no transmisibles, enfatizando acciones poblacionales para controlar las enfermedades cardiovasculares, diabetes, cancer y enfermedad respiratoria cronica, predominantemente por el control del cigarro, inactividad fisica, alimentacion inadecuada y uso perjudicial de alcohol. A pesar de la produccion cientifica significativa sobre tales enfermedades y sus factores de riesgo en Brasil, pocos son los estudios de cohorte en este tema. En este contexto, el Estudio Longitudinal de la Salud del Adulto (ELSA-Brasil) acompana 15.105 servidores publicos del pais. Sus datos reflejan la realidad brasilena de altas prevalencias de diabetes e hipertension y de los factores de riesgo. La diversidad de las informaciones producidas permitira profundizar el entendimiento causal de tales enfermedades y subsidiar politicas publicas para enfrentarlas.

Risco e proteção: em busca de um equilíbrio promotor de resiliência

Abstract: The article analyzes the relationship of the resilience with unfavorable life events and protection factors The sample of that study belonged to 997 school adolescents of the public schools of Sao Goncalo/RJ As measure of resilience was used the Resilience Scale developed by Wagnild & Young (1993) To measure Life Events were used scale of physical violence (Straus, 1979) and psychological violence (Pitzer & Drummond, 1997), violence items in the school and in the place, violence among siblings and among parents, sexual violence and others As protection factors were used the Scale of Social Support of Shebourne e Stewart (Chor, Grip, Lopes & Farstein, 2001), the Scale of Self-Esteem of Rosemberg (1989), family supervision, relationship with friends and teachers It was observed that the negative life events didn't present relationship with the resilience On the other hand, the appraised protection factors were shown all correlated with the resilience

Broad Repertoire of the CD4+ Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes

Abstract: A vigorous hepatitis C virus (HCV)-specific Th cell response is regarded as essential to the immunological control of HCV viremia. The aim of this study was to comprehensively define the breadth and specificity of dominant HCV-specific CD4(+) T cell epitopes in large cohorts of subjects with chronic and spontaneously resolved HCV viremia. Following in vitro stimulation of PBMC, HCV-specific cell cultures from each subject were screened with an overlapping panel of synthetic 20-mer peptides spanning the entire HCV polyprotein. Of 22 subjects who spontaneously controlled HCV viremia, all recognized at least one of a group of six epitopes situated within the nonstructural (NS) proteins NS3, NS4, and NS5, each of which was detected by >30% of subjects, but most subjects recognized additional, more heterogeneous specificities. In contrast, none of the most frequently targeted epitopes was detected by >5% of persons with chronic infection. The most frequently recognized peptides showed promiscuous binding to multiple HLA-DR molecules in in vitro binding assays and were restricted by different HLA-DR molecules in functional assays in different persons. These data demonstrate that predominant CD4(+) T cell epitopes in persons with resolved HCV infection are preferentially located in the nonstructural proteins and are immunogenic in the context of multiple class II molecules. This comprehensive characterization of CD4(+) T cell epitopes in resolved HCV infection provides important information to facilitate studies of immunopathogenesis and HCV vaccine design and evaluation.

Towards a paradigm shift in the treatment of chronic Chagas disease

Abstract: Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Peron"; Argentina