Institution
Paris Descartes University
Government•Paris, France•
About: Paris Descartes University is a government organization based out in Paris, France. It is known for research contribution in the topics: Population & Transplantation. The organization has 20987 authors who have published 37456 publications receiving 1206222 citations. The organization is also known as: Université Paris V-Descartes & Université de Paris V.
Topics: Population, Transplantation, Immune system, Cancer, Pregnancy
Papers published on a yearly basis
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TL;DR: The genetic, immunological, and clinical features of patients with inborn errors of IFN-γ-dependent immunity, as well as the high level of allelic heterogeneity, are reviewed.
523 citations
University of Turin1, Ludwig Maximilian University of Munich2, Dresden University of Technology3, Radboud University Nijmegen4, Tohoku University5, Paris Descartes University6, University of Queensland7, University of Wrocław8, Ljubljana University Medical Centre9, Mayo Clinic10, University of Mississippi11, Hudson Institute of Medical Research12
TL;DR: Consensus was reached for criteria for six outcomes based on blood pressure, use of antihypertensive drugs, plasma potassium and aldosterone concentrations, and plasma renin concentrations or activities based on clinical and biochemical outcomes.
523 citations
Paris Descartes University1, Cedars-Sinai Medical Center2, University of Alberta3, Johns Hopkins University4, University of Paris5, Autonomous University of Barcelona6, Westmead Hospital7, Harvard University8, University of Texas Medical Branch9, Yeshiva University10, University of Cologne11, Mayo Clinic12, University of Maryland, Baltimore13, Charité14, Leiden University15, University of Manitoba16, Washington University in St. Louis17, NewYork–Presbyterian Hospital18, University of North Carolina at Chapel Hill19, University of Pittsburgh20, University of California, Los Angeles21, Hammersmith Hospital22, Cornell University23, Northwestern University24
TL;DR: Improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification are included.
522 citations
TL;DR: A novel mechanism of tumor escape by which VEGF-A directly triggers Treg proliferation which is inhibited by VEGf-A/VEGFR-2 blockade and anti-VEGF-A therapies also have immunologic effects that may be used with a therapeutic goal in the future.
Abstract: A central pathway of tumor angiogenesis also has a pivotal role in driving immune escape, illustrating a tight integration of pathways driving malignant progression.
522 citations
TL;DR: Aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations, which are validated in an independent cohort of 77 ACCs.
Abstract: Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous. We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs. ZNRF3, encoding a cell surface E3 ubiquitin ligase, was the most frequently altered gene (21%) and is a potential new tumor suppressor gene related to the β-catenin pathway. Our integrated genomic analyses further identified two distinct molecular subgroups with opposite outcome. The C1A group of ACCs with poor outcome displayed numerous mutations and DNA methylation alterations, whereas the C1B group of ACCs with good prognosis displayed specific deregulation of two microRNA clusters. Thus, aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations.
520 citations
Authors
Showing all 21023 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Guido Kroemer | 236 | 1404 | 246571 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| Jean-Laurent Casanova | 144 | 842 | 76173 |
| Alain Fischer | 143 | 770 | 81680 |
| Maxime Dougados | 134 | 1054 | 69979 |
| Carlos López-Otín | 126 | 494 | 83933 |
| Giuseppe Viale | 123 | 740 | 72799 |
| Thierry Poynard | 119 | 668 | 64548 |
| Lorenzo Galluzzi | 118 | 477 | 71436 |
| Shahrokh F. Shariat | 118 | 1637 | 58900 |
| Richard E. Tremblay | 116 | 685 | 45844 |
| Olivier Hermine | 111 | 1026 | 43779 |
| Yehezkel Ben-Ari | 110 | 459 | 44293 |
| Loïc Guillevin | 108 | 800 | 51085 |
| Gérard Socié | 107 | 920 | 44186 |