Institution
Paris Descartes University
Government•Paris, France•
About: Paris Descartes University is a government organization based out in Paris, France. It is known for research contribution in the topics: Population & Transplantation. The organization has 20987 authors who have published 37456 publications receiving 1206222 citations. The organization is also known as: Université Paris V-Descartes & Université de Paris V.
Topics: Population, Transplantation, Immune system, Cancer, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: The cancer-cell-intrinsic and -extrinsics factors that regulate metastasis are outlined, the key role of natural killer cells in the control of metastatic dissemination is discussed, and potential therapeutic approaches to prevent or target metastatic disease are presented.
476 citations
University of Amsterdam1, Utrecht University2, University of Virginia3, Brown University4, Bond University5, University of Sydney6, Ottawa Hospital Research Institute7, University of Ottawa8, University of California, San Francisco9, VU University Medical Center10, Beth Israel Deaconess Medical Center11, Boston Children's Hospital12, Northwestern University13, University of Oxford14, Paris Descartes University15
TL;DR: An updated list of 30 essential items that should be included in every report of a diagnostic accuracy study is presented, which incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD.
Abstract: Incomplete reporting has been identified as a major source of avoidable waste in biomedical research. Essential information is often not provided in study reports, impeding the identification, critical appraisal, and replication of studies. To improve the quality of reporting of diagnostic accuracy studies, the Standards for Reporting of Diagnostic Accuracy Studies (STARD) statement was developed. Here we present STARD 2015, an updated list of 30 essential items that should be included in every report of a diagnostic accuracy study. This update incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD. As such, STARD 2015 may help to improve completeness and transparency in reporting of diagnostic accuracy studies.
476 citations
TL;DR: Amoxicillin plus clavulanic acid was not non-inferior to emergency appendicectomy for treatment of acute appendicitis and Identification of predictive markers on CT scans might enable improved targeting of antibiotic treatment.
475 citations
Northwestern University1, Lucile Packard Children's Hospital2, University of Pennsylvania3, University of Sydney4, Royal Prince Alfred Hospital5, Centenary Institute6, University of Paris7, Mahidol University8, University of California, Los Angeles9, Université Paris-Saclay10, Paris Descartes University11, Pierre-and-Marie-Curie University12, German Cancer Research Center13, Children's Hospital Oakland Research Institute14, Harvard University15
TL;DR: Gene therapy with autologous CD34+ cells transduced with the BB305 vector reduced or eliminated the need for long‐term red‐cell transfusions in 22 patients with severe β‐thalassemia without serious adverse events related to the drug product.
Abstract: Background Donor availability and transplantation-related risks limit the broad use of allogeneic hematopoietic-cell transplantation in patients with transfusion-dependent β-thalassemia. After previously establishing that lentiviral transfer of a marked β-globin (βA-T87Q) gene could substitute for long-term red-cell transfusions in a patient with β-thalassemia, we wanted to evaluate the safety and efficacy of such gene therapy in patients with transfusion-dependent β-thalassemia. Methods In two phase 1–2 studies, we obtained mobilized autologous CD34+ cells from 22 patients (12 to 35 years of age) with transfusion-dependent β-thalassemia and transduced the cells ex vivo with LentiGlobin BB305 vector, which encodes adult hemoglobin (HbA) with a T87Q amino acid substitution (HbAT87Q). The cells were then reinfused after the patients had undergone myeloablative busulfan conditioning. We subsequently monitored adverse events, vector integration, and levels of replication-competent lentivirus. Efficac...
474 citations
TL;DR: This work reports strong association between FCGR3B copy number and risk of systemic lupus erythematosus, microscopic polyangiitis and Wegener's granulomatosis in two independent cohorts from the UK and France.
Abstract: Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P = 2.9 x 10(-4)) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 x 10(-3)) and France (P = 1.1 x 10(-4)). We did not observe this association in the organ-specific Graves' disease or Addison's disease. Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity.
472 citations
Authors
Showing all 21023 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Guido Kroemer | 236 | 1404 | 246571 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| Jean-Laurent Casanova | 144 | 842 | 76173 |
| Alain Fischer | 143 | 770 | 81680 |
| Maxime Dougados | 134 | 1054 | 69979 |
| Carlos López-Otín | 126 | 494 | 83933 |
| Giuseppe Viale | 123 | 740 | 72799 |
| Thierry Poynard | 119 | 668 | 64548 |
| Lorenzo Galluzzi | 118 | 477 | 71436 |
| Shahrokh F. Shariat | 118 | 1637 | 58900 |
| Richard E. Tremblay | 116 | 685 | 45844 |
| Olivier Hermine | 111 | 1026 | 43779 |
| Yehezkel Ben-Ari | 110 | 459 | 44293 |
| Loïc Guillevin | 108 | 800 | 51085 |
| Gérard Socié | 107 | 920 | 44186 |