Institution
Paris Descartes University
Government•Paris, France•
About: Paris Descartes University is a government organization based out in Paris, France. It is known for research contribution in the topics: Population & Transplantation. The organization has 20987 authors who have published 37456 publications receiving 1206222 citations. The organization is also known as: Université Paris V-Descartes & Université de Paris V.
Topics: Population, Transplantation, Immune system, Cancer, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: A two-dose regimen with an adjuvanted 30 microg inactivated H5N1 vaccine was safe and showed an immune response consistent with European regulatory requirements for licensure of seasonal influenza vaccine.
415 citations
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Leiden University Medical Center1, University of Toronto2, Paris Descartes University3, Université de Montréal4, University of Groningen5, University of Crete6, University of Lisbon7, University of Southampton8, Istanbul University9, Autonomous University of Madrid10, Ghent University11, University of Giessen12, University College Cork13, University of Copenhagen14, Universidade Federal de Santa Catarina15, University of Naples Federico II16, Menzies Research Institute17
TL;DR: In the 3E (Evidence, Expertise, Exchange) Initiative of 2007-8, 751 rheumatologists from 17 countries participated in three separate rounds of discussions and Delphi votes as mentioned in this paper.
Abstract: Objectives: To develop evidence-based recommendations for the use of methotrexate in daily clinical practice in rheumatic disorders. Methods: 751 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2007–8 consisting of three separate rounds of discussions and Delphi votes. Ten clinical questions concerning the use of methotrexate in rheumatic disorders were formulated. A systematic literature search in Medline, Embase, Cochrane Library and 2005–7 American College of Rheumatology/European League Against Rheumatism meeting abstracts was conducted. Selected articles were systematically reviewed and the evidence was appraised according to the Oxford levels of evidence. Each country elaborated a set of national recommendations. Finally, multinational recommendations were formulated and agreement among the participants and the potential impact on their clinical practice was assessed. Results: A total of 16 979 references was identified, of which 304 articles were included in the systematic reviews. Ten multinational key recommendations on the use of methotrexate were formulated. Nine recommendations were specific for rheumatoid arthritis (RA), including the work-up before initiating methotrexate, optimal dosage and route, use of folic acid, monitoring, management of hepatotoxicity, long-term safety, mono versus combination therapy and management in the perioperative period and before/during pregnancy. One recommendation concerned methotrexate as a steroid-sparing agent in other rheumatic diseases. Conclusions: Ten recommendations for the use of methotrexate in daily clinical practice focussed on RA were developed, which are evidence based and supported by a large panel of rheumatologists, enhancing their validity and practical use.
415 citations
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TL;DR: A SIFT-like algorithm specifically dedicated to SAR imaging, which includes both the detection of keypoints and the computation of local descriptors, and an application of SAR-SIFT to the registration of SAR images in different configurations, particularly with different incidence angles is presented.
Abstract: The scale-invariant feature transform (SIFT) algorithm and its many variants are widely used in computer vision and in remote sensing to match features between images or to localize and recognize objects. However, mostly because of speckle noise, it does not perform well on synthetic aperture radar (SAR) images. In this paper, we introduce a SIFT-like algorithm specifically dedicated to SAR imaging, which is named SAR-SIFT. The algorithm includes both the detection of keypoints and the computation of local descriptors. A new gradient definition, yielding an orientation and a magnitude that are robust to speckle noise, is first introduced. It is then used to adapt several steps of the SIFT algorithm to SAR images. We study the improvement brought by this new algorithm, as compared with existing approaches. We present an application of SAR-SIFT to the registration of SAR images in different configurations, particularly with different incidence angles.
414 citations
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Marche Polytechnic University1, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico2, VU University Medical Center3, University of Palermo4, Paris Descartes University5, University of Bari6, Seconda Università degli Studi di Napoli7, University of Erlangen-Nuremberg8, Royal Hallamshire Hospital9, Beth Israel Deaconess Medical Center10, University of Oslo11, University of Parma12, Alexandra Hospital13, Oslo University Hospital14, University of Mainz15, Charité16, University of Bologna17, Harvard University18
TL;DR: Experts’ recommendations on how the diagnostic protocol should be performed for the confirmation of non-Celiac Gluten Sensitivity are reported, to help the clinician to reach a firm and positive diagnosis of NCGS.
Abstract: Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease or wheat allergy. Given the lack of a NCGS biomarker, there is the need for standardizing the procedure leading to the diagnosis confirmation. In this paper we report experts’ recommendations on how the diagnostic protocol should be performed for the confirmation of NCGS. A full diagnostic procedure should assess the clinical response to the gluten-free diet (GFD) and measure the effect of a gluten challenge after a period of treatment with the GFD. The clinical evaluation is performed using a self-administered instrument incorporating a modified version of the Gastrointestinal Symptom Rating Scale. The patient identifies one to three main symptoms that are quantitatively assessed using a Numerical Rating Scale with a score ranging from 1 to 10. The double-blind placebo-controlled gluten challenge (8 g/day) includes a one-week challenge followed by a one-week washout of strict GFD and by the crossover to the second one-week challenge. The vehicle should contain cooked, homogeneously distributed gluten. At least a variation of 30% of one to three main symptoms between the gluten and the placebo challenge should be detected to discriminate a positive from a negative result. The guidelines provided in this paper will help the clinician to reach a firm and positive diagnosis of NCGS and facilitate the comparisons of different studies, if adopted internationally.
414 citations
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Technische Universität München1, Ludwig Maximilian University of Munich2, Max Planck Society3, University of Tübingen4, Paris Descartes University5, Boston Children's Hospital6, University of Paris7, French Institute of Health and Medical Research8, Centre national de la recherche scientifique9, Newcastle University10, Paracelsus Private Medical University of Salzburg11, University of Düsseldorf12
TL;DR: The power of transcriptome sequencing is demonstrated to molecularly diagnose 10% of mitochondriopathy patients and identify candidate genes for the remainder, and examples of intronic loss-of-function variants with pathological relevance are provided.
Abstract: Across a variety of Mendelian disorders, ∼50-75% of patients do not receive a genetic diagnosis by exome sequencing indicating disease-causing variants in non-coding regions. Although genome sequencing in principle reveals all genetic variants, their sizeable number and poorer annotation make prioritization challenging. Here, we demonstrate the power of transcriptome sequencing to molecularly diagnose 10% (5 of 48) of mitochondriopathy patients and identify candidate genes for the remainder. We find a median of one aberrantly expressed gene, five aberrant splicing events and six mono-allelically expressed rare variants in patient-derived fibroblasts and establish disease-causing roles for each kind. Private exons often arise from cryptic splice sites providing an important clue for variant prioritization. One such event is found in the complex I assembly factor TIMMDC1 establishing a novel disease-associated gene. In conclusion, our study expands the diagnostic tools for detecting non-exonic variants and provides examples of intronic loss-of-function variants with pathological relevance.
414 citations
Authors
Showing all 21023 results
Name | H-index | Papers | Citations |
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Guido Kroemer | 236 | 1404 | 246571 |
Cyrus Cooper | 204 | 1869 | 206782 |
Jean-Laurent Casanova | 144 | 842 | 76173 |
Alain Fischer | 143 | 770 | 81680 |
Maxime Dougados | 134 | 1054 | 69979 |
Carlos López-Otín | 126 | 494 | 83933 |
Giuseppe Viale | 123 | 740 | 72799 |
Thierry Poynard | 119 | 668 | 64548 |
Lorenzo Galluzzi | 118 | 477 | 71436 |
Shahrokh F. Shariat | 118 | 1637 | 58900 |
Richard E. Tremblay | 116 | 685 | 45844 |
Olivier Hermine | 111 | 1026 | 43779 |
Yehezkel Ben-Ari | 110 | 459 | 44293 |
Loïc Guillevin | 108 | 800 | 51085 |
Gérard Socié | 107 | 920 | 44186 |