Paris Descartes University

TL;DR: Remodeling of gap junctions occurs early in Naxos disease, presumably because of abnormal linkage between mechanical junctions and the cytoskeleton, and Gap junction remodeling may produce a coupling defect which, combined with the subsequent development of pathologic changes in myocardium, could contribute to a highly arrhythmogenic substrate and enhance the risk of sudden death in Nxos disease.

TL;DR: The findings strongly support the idea that, although pediatric mastocytosis can spontaneously regress, it is a clonal disease most commonly associated with activating mutations in c-KIT.

TL;DR: Premature vascular aging and arterial stiffening are observed with progression of chronic kidney disease and in end-stage renal disease and this accelerated aging is associated with outward remodeling of large vessels, characterized by increased arterial radius not totally compensated for by artery wall hypertrophy.

TL;DR: Investigation of the incidence and prevalence of juvenile idiopathic arthritis in Europe for 2010 found that the number of affected children can be useful, especially with the new treatment possibilities.