scispace - formally typeset
Search or ask a question
Institution

ParisTech

EducationParis, France
About: ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Residual stress & Finite element method. The organization has 1888 authors who have published 1965 publications receiving 55532 citations. The organization is also known as: Paris Institute of Technology & ParisTech Développement.


Papers
More filters
Journal ArticleDOI
TL;DR: An Ion Torrent’s PGM-based routine diagnostic procedure for BRCA1/2 sequencing is developed, and the pipeline described can be adapted by any user of PGM for diagnostic purposes.
Abstract: To meet challenges in terms of throughput and turnaround time, many diagnostic laboratories are shifting from Sanger sequencing to higher throughput next-generation sequencing (NGS) platforms. Bearing in mind that the performance and quality criteria expected from NGS in diagnostic or research settings are strikingly different, we have developed an Ion Torrent's PGM-based routine diagnostic procedure for BRCA1/2 sequencing. The procedure was first tested on a training set of 62 control samples, and then blindly validated on 77 samples in parallel with our routine technique. The training set was composed of difficult cases, for example, insertions and/or deletions of various sizes, large-scale rearrangements and, obviously, mutations occurring in homopolymer regions. We also compared two bioinformatic solutions in this diagnostic context, an in-house academic pipeline and the commercially available NextGene software (Softgenetics). NextGene analysis provided higher sensitivity, as four previously undetected single-nucleotide variations were found. Regarding specificity, an average of 1.5 confirmatory Sanger sequencings per patient was needed for complete BRCA1/2 screening. Large-scale rearrangements were identified by two distinct analyses, that is, bioinformatics and fragment analysis with electrophoresis profile comparison. Turnaround time was enhanced, as a series of 30 patients were sequenced by one technician, making the results available for the clinician in 10 working days following blood sampling. BRCA1/2 genes are a good model, representative of the difficulties commonly encountered in diagnostic settings, which is why we believe our findings are of interest for the whole community, and the pipeline described can be adapted by any user of PGM for diagnostic purposes.

55 citations

Journal ArticleDOI
TL;DR: In this article, numerical simulations for predicting uni-and multi-axial ratchetting behaviors are carried out, using a polycrystal plasticity model, which is applied to simulate the experimental results from the literature for a 316 austenitic stainless steel and for a 1026 carbon steel.
Abstract: In this work, numerical simulations for predicting uni- and multi-axial ratchetting behaviors are carried out, using a polycrystal plasticity model. In this multi-scale modeling, the single crystal behavior is based on crystallographic slip (intragranular scale), whereas the polycrystal behavior is obtained from an explicit transition rule to calculate the local stresses and strains (intergranular scale). A systematic study is performed to show the effect of intergranular and intragranular hardening on the ratchetting behavior. For illustrative purposes, two examples are presented: the model is applied to simulate the experimental results from the literature for a 316 austenitic stainless steel and for a 1026 carbon steel. It was demonstrated that the polycrystalline model was successful in describing the inelastic behavior of the two considered materials adequately.

55 citations

Journal ArticleDOI
TL;DR: In this article, the authors present the first experimental acquisition of shock remanence by lunar rocks in the 0.1-2-GPa range and discuss their implications for the interpretation of the paleomagnetic record of these rocks, as well as for the distribution of magnetic anomalies revealed by orbital data.

55 citations

Journal ArticleDOI
TL;DR: In this article, the stability of a nonlinear response of a Duffing oscillator under a bi-periodic excitation has been compared with a modified 1D harmonic balance approach.
Abstract: Quasi-periodic motions and their stability are addressed from the point of view of different harmonic balance-based approaches. Two numerical methods are used: a generalized multidimensional version of harmonic balance and a modification of a classical solution by harmonic balance. The application to the case of a nonlinear response of a Duffing oscillator under a bi-periodic excitation has allowed a comparison of computational costs and stability evaluation results. The solutions issued from both methods are close to one another and time marching tests showing a good agreement with the harmonic balance results confirm these nonlinear responses. Besides the overall adequacy verification, the observation comparisons would underline the fact that while the 2D approach features better performance in resolution cost, the stability computation turns out to be of more interest to be conducted by the modified 1D approach.

54 citations

Journal ArticleDOI
TL;DR: In this article, a variable reference flux adaptation method was proposed to improve the post-fault performance of parallel-connected converters in six-phase induction machines, which provided higher torque/power capability, lower degree of imbalance in the current sharing between windings and efficiency improvement.
Abstract: The redundancy of multiphase drives provides an inherent fault-tolerant capability that is appreciated in applications with a complicated corrective maintenance or safety-critical requirements. Fault restrictions, however, force the system to be reconfigured to operate in a smooth and efficient manner. Previous works have been focused on the optimization of current waveforms to generate an undisturbed operation but still maintaining the prefault rated flux settings. This study shows that efficient controllers can improve the postfault performance in six-phase induction machines supplied by parallel-connected converters if offline optimization is used to obtain a variable reference flux. Theoretical and experimental results confirm that the proposed flux adaptation method provides higher torque/power capability, lower degree of imbalance in the current sharing between windings and efficiency improvement.

54 citations


Authors

Showing all 1899 results

NameH-indexPapersCitations
Mathias Fink11690051759
George G. Malliaras9438228533
Mickael Tanter8558329452
Gerard Mourou8265334147
Catherine Lapierre7922718286
Carlo Adamo7544436092
Jean-François Joanny7229420700
Marie-Paule Lefranc7238121087
Paul B. Rainey7022217930
Vincent Lepetit7026826207
Bernard Asselain6940923648
Michael J. Baker6939420834
Jacques Prost6819819064
Jean-Philippe Vert6723517593
Jacques Mairesse6631020539
Network Information
Related Institutions (5)
Royal Institute of Technology
68.4K papers, 1.9M citations

91% related

École Normale Supérieure
99.4K papers, 3M citations

90% related

RWTH Aachen University
96.2K papers, 2.5M citations

89% related

Eindhoven University of Technology
52.9K papers, 1.5M citations

89% related

École Polytechnique Fédérale de Lausanne
98.2K papers, 4.3M citations

89% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20239
202212
202174
202093
2019127
2018145