ParisTech

About: ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Residual stress & Finite element method. The organization has 1888 authors who have published 1965 publications receiving 55532 citations. The organization is also known as: Paris Institute of Technology & ParisTech Développement.

Oxaliplatin use in pressurized intraperitoneal aerosol chemotherapy (PIPAC) is safe and effective: A multicenter study.

Abstract: Introduction Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new drug delivery method used in patients with peritoneal cancer (PC) of primary or secondary origin. Intraperitoneal use of oxaliplatin raises concerns about toxicity, especially abdominal pain. The objective of this study was to assess the tolerance of PIPAC with oxaliplatin (PIPAC-Ox) in a large cohort of patients and to identify the risk factors for high grade toxicity, discontinuation of treatment and impaired survival. Material and methods This retrospective cohort study included all consecutive patients treated with PIPAC-Ox (92 mg/m2) in five centers specialized in the treatment of PC. The procedure was repeated every 6 weeks. Outcomes of interest were Common Terminology Criteria for Adverse Events (CTCAE), symptoms and survival (Kaplan-Meier). Univariate risk factors were included in a multinominal regression model to control for bias. Results Overall, 251 PIPAC-Ox treatments were performed in 101 patients (45 female) having unresectable PC of various origins: 66 colorectal, 15 gastric, 5 ovarian, 3 mesothelioma, 2 pseudomyxoma, 10 other malignancies (biliary, pancreatic, endocrine) respectively. The median PCI was 19 (IQR: 10–28). Postoperative abdominal pain was present in 23 patients. Out of the 9 patients with grade 3 abdominal pain, only 3 needed a change of PIPAC drug. CTCAE 4.0 toxicity grade 4 or higher was encountered in 16(15.9%) patients. The patients had a mean of 2.5 procedures/patient (SD = 1.5). 50 subjects presented with symptom improvement. Conclusions Oxaliplatin-based PIPAC appears to be a safe treatment that offers good symptom control and promising survival for patients with advanced peritoneal disease.

Bulk elastic fingering instability in Hele-Shaw cells.

Abstract: We demonstrate experimentally the existence of a purely elastic, nonviscous fingering instability which arises when air penetrates into an elastomer confined in a Hele-Shaw cell. Fingers appear sequentially and propagate within the bulk of the material as soon as a critical strain, independent of the elastic modulus, is exceeded. Key elements in the driving force of the instability are the confinement of the gel and its adhesion to the plates of the cell, which result in a considerable expense of elastic energy during the growth of the air bubble.

Color-based underwater object recognition using water light attenuation

Abstract: In this article we present a new approach for object recognition in a robotic underwater context. Color is an attractive feature because of its simplicity and its robustness to scale changes, object positions and partial occlusions. Unfortunately, in the underwater medium, the colors are modified by attenuation and are not constant with the distance. To perform a color-based recognition of an object, we develop an algorithm robust with respect to the attenuation which takes into account the light modification during its path between the light source and the camera. Therefore, a given underwater object can be identified in an image by detecting all the colors compatible with its prior known color. Our method is fast, robust and needs a very few computers resources. We successfully used it when experimenting in the sea using a system we built. It is suitable for robotic applications where computers resources are limited and shared between various embedded devices. This novel concept enables the use of the color in many applications such as target interception, object tracking or obstacle detection.