Paul Sabatier University

About: Paul Sabatier University is a education organization based out in Toulouse, France. It is known for research contribution in the topics: Population & Adipose tissue. The organization has 15431 authors who have published 23386 publications receiving 858364 citations.

Gamma-Ray Emission Concurrent with the Nova in the Symbiotic Binary V407 Cygni

Abstract: Novae are thermonuclear explosions on a white dwarf surface fueled by mass accreted from a companion star. Current physical models posit that shocked expanding gas from the nova shell can produce x-ray emission, but emission at higher energies has not been widely expected. Here, we report the Fermi Large Area Telescope detection of variable γ-ray emission (0.1 to 10 billion electron volts) from the recently detected optical nova of the symbiotic star V407 Cygni. We propose that the material of the nova shell interacts with the dense ambient medium of the red giant primary and that particles can be accelerated effectively to produce π0 decay γ-rays from proton-proton interactions. Emission involving inverse Compton scattering of the red giant radiation is also considered and is not ruled out.

Mechanisms controlling the transition from glow silent discharge to streamer discharge in nitrogen

Abstract: Low-energy dielectric-barrier controlled discharges in nitrogen are studied by undertaking electrical measurements to determine mechanisms controlling the transition from glow to streamer-like discharge. The highest and the lowest values of the frequency and the amplitude of power supply voltage leading to a glow discharge have been found dependent on the gas flow and the nature of the surface in contact with the discharge. These boundary values have been related to the criteria necessary for initiating a Townsend breakdown rather than a streamer breakdown commonly observed under such conditions. This implies: (1) that the seed electron density just before the breakdown is high enough to allow the development of numerous small avalanches under a low field avoiding the formation of only one large avalanche mechanism at the origin of the streamer formation; and (2) to let the time for ions issued from the first avalanches to reach the cathode before the electrical field becomes large enough to induce the formation of large avalanches. Practically, the transition from a Townsend breakdown to a streamer breakdown is analyzed from electrical measurements data coupled to the visual aspect of the discharge. Without any gas flow, the obtaining of an atmospheric pressure glow discharge (APGD) is mainly limited by the species etched from the surface in contact with the gas. Indeed, these species can be quenchers of the nitrogen metastable molecules, which are the species at the origin of the formation of seed electrons via the Penning effect. This limitation can be overcome by the use of a laminar gas flow. However, this type of gas flow through the discharge induces a depletion of N/sub 2/ metastables and, consequently, influences the electron density at the entrance of the discharge, leading to a tendency on this part of the discharge to transit to a streamer-like one.

A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae.

Abstract: Summary Penicillin resistance in Streptococcus pneumoniae has been attributed so far to the production of penicillin-binding protein (PBP) variants with decreased affinities for β-lactam antibiotics. Cefotaxime-resistant laboratory mutants, selected after several steps on increasing concentrations of this β-lactam, become deficient in transformation as well. A DNA fragment conferring both cefotaxime resistance and transformation deficiency was isolated and cloned from the mutant C306. The cefotaxime resistance associated with this resistance determinant was not accompanied with apparent changes in PBP properties, and it mapped on the chromosome distinct from the known resistance determinants, genes encoding PBP2x, PBP1a or PBP2b. Determination of a 2265 bp DNA sequence of the resistance determinant revealed two open reading frames, claR and claH, whose deduced amino acid sequence identified the corresponding proteins as the response regulator and histidine kinase receptor, respectively (members of the two families of bacterial signal-transducing proteins). Two hydrophobic peptide regions divided the histidine kinase ClaH into two putative domains: an N-terminal extracelluiar sensor part, and an intracelluiar C-terminal domain with the conserved His-226 residue, the presumed phosphorylation site. The single point mutations responsible for cefotaxime-resistance and transformation deficiency of C306 and of another two independently isolated cefotaxime-resistant mutants were each located in the C-terminal half of ClaH. A small extracellular protein, the competence factor, is required for induction of competence. Neither C306 nor the transformants obtained with the mutated claH gene produced competence factor, and exogenous competence factor could not complement the transformation deficiency, indicating that the signal-transducing system cia is involved in early steps of competence regulation.