Paul Sabatier University

About: Paul Sabatier University is a education organization based out in Toulouse, France. It is known for research contribution in the topics: Population & Adipose tissue. The organization has 15431 authors who have published 23386 publications receiving 858364 citations.

A probabilistic approach to the geometry of the ℓᵨⁿ-ball

Abstract: This article investigates, by probabilistic methods, various geometric questions on B n p , the unit ball of ln p . We propose realizations in terms of independent random variables of several distributions on B n p , including the normalized volume measure. These representations allow us to unify and extend the known results of the sub-independence of coordinate slabs in B n p . As another application, we compute moments of linear functionals on B n p , which gives sharp constants in Khinchine's inequalities on B n p and determines the 2-constant of all directions on B n p . We also study the extremal values of several Gaussian averages on sections of B n p (including mean width and l-norm), and derive several monotonicity results as p varies. Applications to balancing vectors in l 2 and to covering numbers of polyhedra complete the exposition.

Cassettes of the Streptoalloteichus hindustanus ble gene for transformation of lower and higher eukaryotes to phleomycin resistance

Abstract: Phleomycins are glycopeptide antibiotics related to bleomycins nucleotide sequence of the Sh ble gene and its polylinker and tallysomycins which are active at low concentrations on both fragments. prokaryotic and eukaryotic cells (1). We have cloned a phleomycin-resistance gene (Sh ble) from the genomic DNA of REFERENCES Streptoalloteichus hindustanus (ATCC 31158), a tallysomycin 1 Berdy,J. (1980) Handbook of.Antibiotic Compounds. Vol.4, pp. 459-491, producer. The Sh ble gene encodes a small acidic protein (MW CRC Press, Boca Raton, FL, USA 13665) which has been crystallised for X-ray structural studies 2. Rondeau,J.M., Cagnon,C., Moras,D. and Masson,J.M. (1989) J. MoI. Biol. (2). The Sh protein is a binding protein with a strong affinity 207, 645-646. for the phleomycin family of antibiotics (3). When these 3. Gatignol,A., Durand,H. and Tiraby,G. (1988) FEBS Lent. 230, 171-175. antibiotics are bound by the Sh protein, then phleomycins can 4. Glumoff,V., Kappeli,O., Fiechter,A. and Reiser,J. (1989) Gene 84, nolonger areactivated by tneffous ions and oxyen teobreakdcan 311-318. no longer be activated by ferrous ions and oxygen to break down 5. Mattern,J.E. and Punt,P.J. (1988) Fungal Genet. Newslett. 35, 25. DNA (3). The Sh ble gene has been used in a number of 6. Perez,P., Tiraby,G., Kallerhoff,J. and Perret,J. (1989) Plant Mol. Biol. 13, laboratories as a selectable marker for lower (4, 5) and higher 365-373. eukaryotes (6, 7, 8). In order to facilitate vector construction 7. Mulsant,P., Gatignol,A., Dalens,M. and Tiraby,G. (1988) Somat. Cell. Mol. exeukryoetes(, 8).theinordgoers wto fac tipltevctoricositruction Genet. 14, 243-252. periment , synthetic oligom with multiple cloning sites have 8. Cosset,F.L., Legras,C., Chebloune,Y., Savater,P., Thoraval,P., been added at both ends of the Sh ble gene to give the two pUC Thomas,J.L., Samarut,J., Nigon,U.M. and Verdier,G. (1990) J. Virol. 64, based derivatives, pUT56 and pUT58. We report here the 1070-1078.

Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus

Abstract: By generating a specialized cDNA library from the archaeon Sulfolobus solfataricus, we have identified 57 novel small non-coding RNA (ncRNA) candidates and confirmed their expression by Northern blot analysis. The majority was found to belong to one of two classes, either antisense or antisense-box RNAs, where the latter only exhibit partial complementarity to RNA targets. The most prominent group of antisense RNAs is transcribed in the opposite orientation to the transposase genes, encoded by insertion elements (transposons). Thus, these antisense RNAs may regulate transposition of insertion elements by inhibiting expression of the transposase mRNA. Surprisingly, the class of antisense RNAs also contained RNAs complementary to tRNAs or sRNAs (small-nucleolar-like RNAs). For the antisense-box ncRNAs, the majority could be assigned to the class of C/D sRNAs, which specify 2'-O-methylation sites on rRNAs or tRNAs. Five C/D sRNAs of this group are predicted to target methylation at six sites in 13 different tRNAs, thus pointing to the widespread role of these sRNA species in tRNA modification in Archaea. Another group of antisense-box RNAs, lacking typical C/D sRNA motifs, was predicted to target the 3'-untranslated regions of certain mRNAs. Furthermore, one of the ncRNAs that does not show antisense elements is transcribed from a repeat unit of a cluster of small regularly spaced repeats in S. solfataricus which is potentially involved in replicon partitioning. In conclusion, this is the first report of stably expressed antisense RNAs in an archaeal species and it raises the prospect that antisense-based mechanisms are also used widely in Archaea to regulate gene expression.

Nanoporous magnets of chiral and racemic [{Mn(HL)}2Mn{Mo(CN)7}2] with switchable ordering temperatures (TC = 85 K 106 K) driven by H2O sorption (L = N,N-dimethylalaninol).

Abstract: Molecule-based solids represent a rare opportunity to combine, adjust, and interrelate structural and physical functionalities to develop multifunctional materials. Here we report on a series of porous supramolecular magnets whose magnetic properties are related to their sorption state. A family of magnets of the formula [{Mn(HL)(H2O)}2Mn{Mo(CN)7}2]·2H2O have been obtained by assembling the heptacyano-metalate building unit {Mo(CN)7}4- with Mn(II) in the presence of protonated N,N-dimethylalaninol (L) as ligand, the latter being either as a racemic mixture or as a chiral R- or S-enantiomer. The resulting magnets possess an open framework structure and exhibit a TC with a switching behavior (TC = 85 K ↔ 106 K) as a function of the hydration state. Moreover, chiral magnets are formed with the optically active ligands. The H2O and gas (N2, CO2, CO) sorption features, the magnetic behavior of both the hydrated and dehydrated magnets, and the crystal structures of the hydrated chiral (S) and racemic magnets ar...