Institution
Paul Sabatier University
Education•Toulouse, France•
About: Paul Sabatier University is a education organization based out in Toulouse, France. It is known for research contribution in the topics: Population & Adipose tissue. The organization has 15431 authors who have published 23386 publications receiving 858364 citations.
Papers published on a yearly basis
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Dresden University of Technology1, VU University Medical Center2, University of Nottingham3, Astellas Pharma4, University of São Paulo5, University of Regensburg6, University Hospital Heidelberg7, Utrecht University8, Royal Devon and Exeter Hospital9, Clalit Health Services10, University of California, San Diego11, King's College London12, St. John's University13, Kyushu University14, University of Giessen15, Cochrane Collaboration16, Osaka University17, University of London18, Ninewells Hospital19, University of New South Wales20, St George's Hospital21, Boston Children's Hospital22, Paul Sabatier University23, Jikei University School of Medicine24, University Medical Center Groningen25, Karolinska University Hospital26, University of Kiel27, Ludwig Maximilian University of Munich28, Nottingham University Hospitals NHS Trust29
TL;DR: Consensus was achieved to include clinical signs, symptoms, long‐term control of flares and quality of life into the core set of outcome domains for atopic eczema trials, and the HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic ecology trials.
Abstract: The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from 10 countries, representing different stakeholders (patients, clinicians, methodologists, pharmaceutical industry) to determine core outcome domains for atopic eczema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics for atopic eczema outcomes research. Delegates were given evidence-based information, followed by structured group discussion and anonymous consensus voting. Consensus was achieved to include clinical signs, symptoms, long-term control of flares and quality of life into the core set of outcome domains for atopic eczema trials. The HOME initiative strongly recommends including and reporting these core outcome domains as primary or secondary endpoints in all future atopic eczema trials. Measures of these core outcome domains need to be valid, sensitive to change and feasible. Prioritized topics of the HOME initiative are the identification/development of the most appropriate instruments for the four core outcome domains. HOME is open to anyone with an interest in atopic eczema outcomes research.
169 citations
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American Museum of Natural History1, Paris Diderot University2, University of Copenhagen3, Paul Sabatier University4, Abdul Wali Khan University Mardan5, University of Bern6, Pompeu Fabra University7, Centre national de la recherche scientifique8, King Saud University9, Deutsches Archäologisches Institut10, University of Potsdam11, Leibniz Association12, University of Strasbourg13, Catalan Institution for Research and Advanced Studies14, Paris Descartes University15
TL;DR: Early domestication selection patterns supporting the neural crest hypothesis are found, which provides a unified developmental origin for common domestic traits and reveals that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.
Abstract: The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between ~4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.
168 citations
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TL;DR: This paper studied natural epigenetic variation in three allotetraploid sibling orchid species (Dactylorhiza majalis s.str, D. traunsteineri s.l., and D. ebudensis) that differ radically in geography/ecology.
Abstract: Epigenetic information includes heritable signals that modulate gene expression but are not encoded in the primary nucleotide sequence. We have studied natural epigenetic variation in three allotetraploid sibling orchid species (Dactylorhiza majalis s.str, D. traunsteineri s.l., and D. ebudensis) that differ radically in geography/ecology. The epigenetic variation released by genome doubling has been restructured in species-specific patterns that reflect their recent evolutionary history and have an impact on their ecology and evolution, hundreds of generations after their formation. Using two contrasting approaches that yielded largely congruent results, epigenome scans pinpointed epiloci under divergent selection that correlate with eco-environmental variables, mainly related to water availability and temperature. The stable epigenetic divergence in this group is largely responsible for persistent ecological differences, which then set the stage for species-specific genetic patterns to accumulate in response to further selection and/or drift. Our results strongly suggest a need to expand our current evolutionary framework to encompass a complementary epigenetic dimension when seeking to understand population processes that drive phenotypic evolution and adaptation.
168 citations
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TL;DR: In this article, the authors studied the Nyong River basin (27,800 km2) located on the northwestern part (Ntem Complex) of the Congo craton (central Africa) and measured the dissolved concentrations of major and trace elements, dissolved organic carbon (DOC) and the 87Sr/86Sr ratios have been measured in more than 20 rivers draining watersheds with various surface areas (∼1 to 28,000 km2).
168 citations
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TL;DR: The results suggest that different neural correlates are involved in recalling a well-learned or recently acquired environment and that different networks of areas subtend egocentric and allocentric strategies.
Abstract: In the past 20 years, many studies in the cognitive neurosciences have analyzed human ability to navigate in recently learned and familiar environments by investigating the cognitive processes involved in successful navigation. In this study, we reviewed the main experimental paradigms and made a cognitive-oriented meta-analysis of fMRI studies of human navigation to underline the importance of the experimental designs and cognitive tasks used to assess navigational skills. We performed a general activation likelihood estimation (ALE) meta-analysis of 66 fMRI experiments to identify the neural substrates underpinning general aspects of human navigation. Four individual ALE analyses were performed to identify the neural substrates of different experimental paradigms (i.e., familiar vs. recently learned environments) and different navigational strategies (allocentric vs. egocentric). Results of the general ALE analysis highlighted a wide network of areas with clusters in the occipital, parietal, frontal and temporal lobes, especially in the parahippocampal cortex. Familiar environments seem to be processed by an extended temporal-frontal network, whereas recently learned environments require activation in the parahippocampal cortex and the parietal and occipital lobes. Allocentric strategy is subtended by the same areas as egocentric strategy, but the latter elicits greater activation in the right precuneus, middle occipital lobe and angular gyrus. Our results suggest that different neural correlates are involved in recalling a well-learned or recently acquired environment and that different networks of areas subtend egocentric and allocentric strategies.
168 citations
Authors
Showing all 15486 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yury Gogotsi | 171 | 956 | 144520 |
Tobin J. Marks | 159 | 1621 | 111604 |
L. Montier | 138 | 403 | 97094 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Olivier Forni | 137 | 548 | 95819 |
J. Aumont | 131 | 299 | 95006 |
Julian I. Schroeder | 120 | 315 | 50323 |
Bruno Vellas | 118 | 1011 | 70667 |
Christopher G. Goetz | 116 | 651 | 59510 |
Didier Dubois | 113 | 742 | 54741 |
Alain Dufresne | 111 | 358 | 45904 |
Henri Prade | 108 | 917 | 54583 |
Louis Bernatchez | 106 | 568 | 35682 |
Walter Wahli | 105 | 365 | 49372 |
Patrice D. Cani | 100 | 370 | 49523 |