Institution
Paul Sabatier University
Education•Toulouse, France•
About: Paul Sabatier University is a education organization based out in Toulouse, France. It is known for research contribution in the topics: Population & Catalysis. The organization has 15431 authors who have published 23386 publications receiving 858364 citations.
Topics: Population, Catalysis, Context (language use), Adipose tissue, Electron
Papers published on a yearly basis
Papers
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TL;DR: Assessment of the palaeogeographic changes preceding the Sturtian glacial period and the long-term evolution of atmospheric carbon dioxide levels using the coupled climate–geochemical model GEOCLIM indicates that tectonic changes could have triggered a progressive transition from a ‘greenhouse’ to an ‘icehouse” climate during the Neoproterozoic era.
Abstract: Geological and palaeomagnetic studies indicate that ice sheets may have reached the Equator at the end of the Proterozoic eon, 800 to 550 million years ago, leading to the suggestion of a fully ice-covered 'snowball Earth'. Climate model simulations indicate that such a snowball state for the Earth depends on anomalously low atmospheric carbon dioxide concentrations, in addition to the Sun being 6 per cent fainter than it is today. However, the mechanisms producing such low carbon dioxide concentrations remain controversial. Here we assess the effect of the palaeogeographic changes preceding the Sturtian glacial period, 750 million years ago, on the long-term evolution of atmospheric carbon dioxide levels using the coupled climate-geochemical model GEOCLIM. In our simulation, the continental break-up of Rodinia leads to an increase in runoff and hence consumption of carbon dioxide through continental weathering that decreases atmospheric carbon dioxide concentrations by 1,320 p.p.m. This indicates that tectonic changes could have triggered a progressive transition from a 'greenhouse' to an 'icehouse' climate during the Neoproterozoic era. When we combine these results with the concomitant weathering effect of the voluminous basaltic traps erupted throughout the break-up of Rodinia, our simulation results in a snowball glaciation.
280 citations
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Paul Sabatier University1, University of Seville2, University of Wisconsin-Madison3, Scripps Research Institute4, University of California, Los Angeles5, Umeå University6, Harvard University7, University of Ulm8, Columbia University9, Stowers Institute for Medical Research10, Yeshiva University11, Rutgers University12, Merck & Co.13, Keio University14, Karolinska Institutet15, University of Colorado Boulder16, Ohio State University17, National Institutes of Health18, Armenian National Academy of Sciences19, Utrecht University20, Anschutz Medical Campus21, Yonsei University22, Max Delbrück Center for Molecular Medicine23, Cornell University24, Research Institute of Molecular Pathology25, Memorial Sloan Kettering Cancer Center26, Howard Hughes Medical Institute27, Swedish University of Agricultural Sciences28, Uppsala University29, University of British Columbia30, Kanazawa University31, University of Debrecen32, University of Utah33, Fox Chase Cancer Center34, Cancer Research UK35, Rockefeller University36, Stanford University37
TL;DR: A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II is proposed.
280 citations
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TL;DR: In this paper, the authors prove the algebraicity of the group of auto-equivalences of saturated dg-categories and prove the existence of reasonable moduli for perfect complexes on a smooth and proper scheme.
Abstract: The purpose of this work is to prove the existence of an algebraic moduli classifying objects in a given triangulated category. To any dg-category T (over some base ring k), we define a D -stack MT in the sense of [HAGII], classifying certain T op -dg-modules. When T is saturated, MT classifies compact objects in the triangulated category [T] associated to T. The main result of this work states that under certain finiteness conditions on T (e.g. if it is saturated) the D -stack MT is locally geometric (i.e. union of open and geometric sub-stacks). As a consequence we prove the algebraicity of the group of auto-equivalences of saturated dg-categories. We also obtain the existence of reasonable moduli for perfect complexes on a smooth and proper scheme, as well as complexes of representations of a finite quiver.
279 citations
National Institutes of Health1, University of Minnesota2, Max Planck Society3, University College London4, Paul Sabatier University5, University of Washington6, French Institute of Health and Medical Research7, Boston University8, University of Tübingen9, deCODE genetics10, Columbia University Medical Center11, Erasmus University Rotterdam12, Stanford University13, University of Thessaly14, Washington University in St. Louis15, Michael J. Fox Foundation16, German Center for Neurodegenerative Diseases17, New York State Department of Health18, University of Paris19, Centre national de la recherche scientifique20, University of Miami21, Indiana University22
TL;DR: A meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants found four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant.
Abstract: We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55–4.30; P = 2 × 10−16). We also show six risk loci associated with proximal gene expression or DNA methylation.
279 citations
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TL;DR: The findings confirm the value of MRD status, as determined by NGS, as a prognostic biomarker in multiple myeloma, and suggest that this approach could be used to adapt treatment strategies in future clinical trials.
278 citations
Authors
Showing all 15486 results
Name | H-index | Papers | Citations |
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Yury Gogotsi | 171 | 956 | 144520 |
Tobin J. Marks | 159 | 1621 | 111604 |
L. Montier | 138 | 403 | 97094 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Olivier Forni | 137 | 548 | 95819 |
J. Aumont | 131 | 299 | 95006 |
Julian I. Schroeder | 120 | 315 | 50323 |
Bruno Vellas | 118 | 1011 | 70667 |
Christopher G. Goetz | 116 | 651 | 59510 |
Didier Dubois | 113 | 742 | 54741 |
Alain Dufresne | 111 | 358 | 45904 |
Henri Prade | 108 | 917 | 54583 |
Louis Bernatchez | 106 | 568 | 35682 |
Walter Wahli | 105 | 365 | 49372 |
Patrice D. Cani | 100 | 370 | 49523 |