Institution
Paul Sabatier University
Education•Toulouse, France•
About: Paul Sabatier University is a education organization based out in Toulouse, France. It is known for research contribution in the topics: Population & Adipose tissue. The organization has 15431 authors who have published 23386 publications receiving 858364 citations.
Papers published on a yearly basis
Papers
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TL;DR: It is argued for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases, and the implications for the physiological roles of metazoan MED subunits are examined.
265 citations
American Museum of Natural History1, University of Copenhagen2, Kitasato University3, Kanazawa University4, University of Bern5, University of New England (Australia)6, Paul Sabatier University7, Griffith University8, Silpakorn University9, Universiti Sains Malaysia10, University of Lausanne11, Monash University Malaysia Campus12, University of Cambridge13, Armenian National Academy of Sciences14, Mahidol University15, Australian National University16, Nara National Research Institute for Cultural Properties17, University of Tokyo18, University of the Ryukyus19, National Museum of Japanese History20, Kyushu University21, National Institute of Genetics22, Trinity College, Dublin23, University of Oxford24, Paris Descartes University25, University of Strasbourg26, University of Illinois at Urbana–Champaign27, Centre national de la recherche scientifique28, National Museum of Natural History29, University of Otago30, Max Planck Society31, École Normale Supérieure32, Technical University of Denmark33, Wellcome Trust Sanger Institute34
TL;DR: Neither interpretation fits the complexity of Southeast Asian history: Both Hòabìnhian hunter-gatherers and East Asian farmers contributed to current Southeast Asian diversity, with further migrations affecting island SEA and Vietnam.
Abstract: The human occupation history of Southeast Asia (SEA) remains heavily debated Current evidence suggests that SEA was occupied by Hoabinhian hunter-gatherers until ~4000 years ago, when farming economies developed and expanded, restricting foraging groups to remote habitats Some argue that agricultural development was indigenous; others favor the "two-layer" hypothesis that posits a southward expansion of farmers giving rise to present-day Southeast Asian genetic diversity By sequencing 26 ancient human genomes (25 from SEA, 1 Japanese Jōmon), we show that neither interpretation fits the complexity of Southeast Asian history: Both Hoabinhian hunter-gatherers and East Asian farmers contributed to current Southeast Asian diversity, with further migrations affecting island SEA and Vietnam Our results help resolve one of the long-standing controversies in Southeast Asian prehistory
265 citations
TL;DR: The impairment of medium-term olfactory memory by imidacloprid is discussed in the context of neural circuits suspected to mediate memory formation in the honeybee brain.
264 citations
TL;DR: In this article, the authors give the optimal conditions for the uniqueness of the positive L-invariant measure and the L 1 -uniqueness of the intrinsic Schrodinger operators on complete non-compact Riemannian manifolds.
264 citations
TL;DR: The rate of severe infections in current practice is similar to that reported in clinical trials, and the risk factors for severe infections include chronic lung and/or cardiac disease, extraarticular involvement, and low IgG before RTX treatment.
Abstract: Objective
The risk of severe infection is a crucial factor in the assessment of the short-term risk:benefit ratio of biologic drugs in rheumatoid arthritis (RA). There is no increase in severe infections in RA patients treated with rituximab (RTX) in controlled trials, but this has not yet been assessed in daily practice. We undertook this study to investigate the occurrence of and risk factors for severe infections in off-trial patients using data from the AutoImmunity and Rituximab (AIR) registry.
Methods
The AIR registry was set up by the French Society of Rheumatology. The charts of patients with severe infections were reviewed.
Results
Of the enrolled patients, 1,303 had at least 1 followup visit at 3 months or later, with a mean ± SD followup period of 1.2 ± 0.8 years (1,629 patient-years). Eighty-two severe infections occurred in 78 patients (5.0 severe infections per 100 patient-years), half of them in the 3 months following the last RTX infusion. Multivariate analysis showed that chronic lung disease and/or cardiac insufficiency (odds ratio 3.0 [95% confidence interval 1.3–7.3], P = 0.01), extraarticular involvement (odds ratio 2.9 [95% confidence interval 1.3–6.7], P = 0.009), and low IgG level (<6 gm/liter) before initiation of RTX treatment (odds ratio 4.9 [95% confidence interval 1.6–15.2], P = 0.005) were significantly associated with increased risk of a severe infection.
Conclusion
The rate of severe infections in current practice is similar to that reported in clinical trials. The risk factors for severe infections include chronic lung and/or cardiac disease, extraarticular involvement, and low IgG before RTX treatment. This suggests that serum IgG should be checked and the risk:benefit ratio of RTX discussed for patients found to have low levels of IgG.
263 citations
Authors
Showing all 15486 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Yury Gogotsi | 171 | 956 | 144520 |
| Tobin J. Marks | 159 | 1621 | 111604 |
| L. Montier | 138 | 403 | 97094 |
| Jean-Paul Kneib | 138 | 805 | 89287 |
| Olivier Forni | 137 | 548 | 95819 |
| J. Aumont | 131 | 299 | 95006 |
| Julian I. Schroeder | 120 | 315 | 50323 |
| Bruno Vellas | 118 | 1011 | 70667 |
| Christopher G. Goetz | 116 | 651 | 59510 |
| Didier Dubois | 113 | 742 | 54741 |
| Alain Dufresne | 111 | 358 | 45904 |
| Henri Prade | 108 | 917 | 54583 |
| Louis Bernatchez | 106 | 568 | 35682 |
| Walter Wahli | 105 | 365 | 49372 |
| Patrice D. Cani | 100 | 370 | 49523 |