Institution
Paul Sabatier University
Education•Toulouse, France•
About: Paul Sabatier University is a education organization based out in Toulouse, France. It is known for research contribution in the topics: Population & Adipose tissue. The organization has 15431 authors who have published 23386 publications receiving 858364 citations.
Papers published on a yearly basis
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TL;DR: In this paper, a H2-CH4 mixture over oxide spinels containing two transition elements as in Mg0.8MyM'zAl2O4 (M, M' = Fe, Co or Ni, y + z = 0.2) at 1070°C produces small alloy nanoparticles which enable the formation of carbon nanotubes.
249 citations
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TL;DR: CNRS-UMR 5068, LSPCMIB, Universite Paul Sabatier, 118 route de Narbonne, F-31062 Toulouse Cedex 9, France, Laboratoire de Chimie Moleculaire et Thio-organique, ENSICAEN, University of Caen Basse-Normandie, FR CNRS 3038, 6 boulevard du Marechal Juin.
Abstract: CNRS-UMR 5068, LSPCMIB, Universite Paul Sabatier, 118 route de Narbonne, F-31062 Toulouse Cedex 9, France, Laboratoire de Chimie Moleculaire et Thio-organique, ENSICAEN, Universite de Caen Basse-Normandie, FR CNRS 3038, 6 boulevard du Marechal Juin, F-14050 Caen, France, CNRS-UMR 6014, IRCOF, Universite de Rouen, rue Tesniere, F-76821 Mont-Saint-Aignan Cedex, France, and URCOM, EA 3221 FR CNRS 3038, Universite du Havre, 25 rue Ph. Lebon, BP 540, F-76058 Le Havre Cedex, France
249 citations
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TL;DR: Results provide strong arguments in favor of the view that the specific movements memorized when learning how to write participate in the visual recognition of graphic shapes and letters.
Abstract: Fast and accurate visual recognition of single characters is crucial for efficient reading. We explored the possible contribution of writing memory to character recognition processes. We evaluated the ability of adults to discriminate new characters from their mirror images after being taught how to produce the characters either by traditional pen-and-paper writing or with a computer keyboard. After training, we found stronger and longer lasting (several weeks) facilitation in recognizing the orientation of characters that had been written by hand compared to those typed. Functional magnetic resonance imaging recordings indicated that the response mode during learning is associated with distinct pathways during recognition of graphic shapes. Greater activity related to handwriting learning and normal letter identification was observed in several brain regions known to be involved in the execution, imagery, and observation of actions, in particular, the left Broca's area and bilateral inferior parietal lobules. Taken together, these results provide strong arguments in favor of the view that the specific movements memorized when learning how to write participate in the visual recognition of graphic shapes and letters.
248 citations
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TL;DR: The present study demonstrates that adipocyte progenitor cells, i.e., the preadipocytes, are included in the CD34+/CD31− cell fraction, which displays distinct features from the adult mesenchymal and hematopoietic stem cells.
Abstract: The stroma-vascular fraction (SVF) of human adipose tissue has recently been described to be composed of endothelial cells identified as CD34+/CD31+ cells, infiltrated/resident macrophages defined as CD14+/CD31+ cells, and a new cell population characterized as CD34+/CD31- cells. To elucidate the cell identity of the adipocyte precursor cells, fluorescent activating cell sorter (FACS) analyses were performed on crude SVF cultured under adipogenic conditions, i.e., serum-deprived medium containing insulin, cortisol, triiodothyronine, and supplemented with a PPARgamma agonist for the first 3 days. The progressive accumulation of lipid droplets was associated with a selective enrichment of the CD34+/CD31- cell population whereas control experiments performed in medium supplemented with 10% serum showed an overall downregulation of the three cell markers without adipogenesis. Among the different cell subsets, the CD34+/CD31- subset was the unique cell fraction able to answer to adipogenic culture conditions. Indeed, a time-dependent expression of adipocyte markers as well as acquisition of adipocyte-typical metabolic activities were observed. In parallel, the gene expression of lipogenic and lipolytic enzymes increased. The ability to differentiate into adipocytes was restricted to cells that did not express the mesenchymal stem cell marker CD105. Furthermore, the CD34+/CD31- cells did not respond to culture conditions used for hematopoietic colony assays. Taken together, the present study demonstrates that adipocyte progenitor cells, i.e., the preadipocytes, are included in the CD34+/CD31- cell fraction, which displays distinct features from the adult mesenchymal and hematopoietic stem cells.
248 citations
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TL;DR: The focus of this review is to describe the different aspects of what is known of the mechanism of membrane permeabilization and associated gene transfer and, by doing so, what are the actual limits of the DNA delivery into cells.
Abstract: Cell membranes can be transiently permeabilized under application of electric pulses. This treatment allows hydrophilic therapeutic molecules, such as anticancer drugs and DNA, to enter into cells and tissues. This process, called electropermeabilization or electroporation, has been rapidly developed over the last decade to deliver genes to tissues and organs, but there is a general agreement that very little is known about what is really occurring during membrane electropermeabilization. It is well accepted that the entry of small molecules, such as anticancer drugs, occurs mostly through simple diffusion after the pulse while the entry of macromolecules, such as DNA, occurs through a multistep mechanism involving the electrophoretically driven interaction of the DNA molecule with the destabilized membrane during the pulse and then its passage across the membrane. Therefore, successful DNA electrotransfer into cells depends not only on cell permeabilization but also on the way plasmid DNA interacts with the plasma membrane and, once into the cytoplasm, migrates towards the nucleus. The focus of this review is to describe the different aspects of what is known of the mechanism of membrane permeabilization and associated gene transfer and, by doing so, what are the actual limits of the DNA delivery into cells.
248 citations
Authors
Showing all 15486 results
Name | H-index | Papers | Citations |
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Yury Gogotsi | 171 | 956 | 144520 |
Tobin J. Marks | 159 | 1621 | 111604 |
L. Montier | 138 | 403 | 97094 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Olivier Forni | 137 | 548 | 95819 |
J. Aumont | 131 | 299 | 95006 |
Julian I. Schroeder | 120 | 315 | 50323 |
Bruno Vellas | 118 | 1011 | 70667 |
Christopher G. Goetz | 116 | 651 | 59510 |
Didier Dubois | 113 | 742 | 54741 |
Alain Dufresne | 111 | 358 | 45904 |
Henri Prade | 108 | 917 | 54583 |
Louis Bernatchez | 106 | 568 | 35682 |
Walter Wahli | 105 | 365 | 49372 |
Patrice D. Cani | 100 | 370 | 49523 |