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Institution

Paul Scherrer Institute

FacilityVilligen, Switzerland
About: Paul Scherrer Institute is a facility organization based out in Villigen, Switzerland. It is known for research contribution in the topics: Neutron & Large Hadron Collider. The organization has 9248 authors who have published 23984 publications receiving 890129 citations. The organization is also known as: PSI.


Papers
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Journal ArticleDOI
TL;DR: A versatile protocol for a method named 'Squassh' (segmentation and quantification of subcellular shapes), which is used for detecting, delineating and quantifyingSubcellular structures in fluorescence microscopy images, implemented in freely available, user-friendly software.
Abstract: Detection and quantification of fluorescently labeled molecules in subcellular compartments is a key step in the analysis of many cell biological processes. Pixel-wise colocalization analyses, however, are not always suitable, because they do not provide object-specific information, and they are vulnerable to noise and background fluorescence. Here we present a versatile protocol for a method named 'Squassh' (segmentation and quantification of subcellular shapes), which is used for detecting, delineating and quantifying subcellular structures in fluorescence microscopy images. The workflow is implemented in freely available, user-friendly software. It works on both 2D and 3D images, accounts for the microscope optics and for uneven image background, computes cell masks and provides subpixel accuracy. The Squassh software enables both colocalization and shape analyses. The protocol can be applied in batch, on desktop computers or computer clusters, and it usually requires <1 min and <5 min for 2D and 3D images, respectively. Basic computer-user skills and some experience with fluorescence microscopy are recommended to successfully use the protocol.

221 citations

Journal ArticleDOI
TL;DR: The present results indirectly support the hypothesis of a serotonin-dopamine dysbalance in schizophrenia and suggest that psilocybin is a valuable tool in the analysis of serotonin- dopamine interactions in acute psychotic states.

221 citations

Journal ArticleDOI
TL;DR: In this article, the wavelength dependences of the Angstrom exponent and particularly of the single scattering albedo are determined for detecting Saharan dust events (SDE) in the high altitude site Jungfraujoch (3580ma.s.l.).
Abstract: . Scattering and absorption coefficients have been measured continuously at several wavelengths since March 2001 at the high altitude site Jungfraujoch (3580ma.s.l.). From these data, the wavelength dependences of the Angstrom exponent and particularly of the single scattering albedo are determined. While the exponent of the single scattering albedo usually increases with wavelength, it decreases with wavelength during Saharan dust events (SDE) due to the greater size of the mineral aerosol particles and their different chemical composition. This change in the sign of the single scattering exponent turns out to be a sensitive means for detecting Saharan dust events. The occurrence of SDE detected by this new method was confirmed by visual inspection of filter colors and by studying long-range back-trajectories. An examination of SDE over a 22-month period shows that SDE are more frequent during the March-June period as well as during October and November. The trajectory analysis indicated a mean traveling time of 96.5h, with the most important source countries situated in the northern and north-western part of the Saharan desert. Most of the SDE do not lead to a detectable increase of the 48-h total suspended particulate matter (TSP) concentration at the Jungfraujoch. During Saharan dust events, the average contribution of this dust to hourly TSP at the Jungfraujoch is 16µg/m3, which corresponds to an annual mean of 0.8µg/m3 or 24% of TSP.

221 citations

Journal ArticleDOI
TL;DR: Strong intensity oscillations in the superstructure rods demonstrate that the Ru substrate is also significantly corrugated down to several monolayers and that the bonding between graphene and Ru is strong and cannot be caused by van der Waals bonds.
Abstract: The structure of a single layer of graphene on Ru(0001) has been studied using surface x-ray diffraction. A surprising superstructure containing 1250 carbon atoms has been determined, whereby 25 x 25 graphene unit cells lie on 23 x 23 unit cells of Ru. Each supercell contains 2 x 2 crystallographically inequivalent subcells caused by corrugation. Strong intensity oscillations in the superstructure rods demonstrate that the Ru substrate is also significantly corrugated down to several monolayers and that the bonding between graphene and Ru is strong and cannot be caused by van der Waals bonds. Charge transfer from the Ru substrate to the graphene expands and weakens the C-C bonds, which helps accommodate the in-plane tensile stress. The elucidation of this superstructure provides important information in the potential application of graphene as a template for nanocluster arrays.

220 citations

Journal ArticleDOI
TL;DR: This paper presented a global stacked record of (230Thex-normalized)10Be deposition in marine sediments representing relative variations in 10Be production rate which are translated into field intensity variations.

220 citations


Authors

Showing all 9348 results

NameH-indexPapersCitations
Andrea Bocci1722402176461
Tobin J. Marks1591621111604
Wolfgang Wagner1562342123391
David D'Enterria1501592116210
Andreas Pfeiffer1491756131080
Christoph Grab1441359144174
Maurizio Pierini1431782104406
Alexander Belyaev1421895100796
Ajit Kumar Mohanty141112493062
Felicitas Pauss1411623104493
Chiara Mariotti141142698157
Luc Pape1411441130253
Rainer Wallny1411661105387
Roland Horisberger1391471100458
Emmanuelle Perez138155099016
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202363
2022199
20211,299
20201,442
20191,330
20181,298