Paul Scherrer Institute

About: Paul Scherrer Institute is a facility organization based out in Villigen, Switzerland. It is known for research contribution in the topics: Neutron & Large Hadron Collider. The organization has 9248 authors who have published 23984 publications receiving 890129 citations. The organization is also known as: PSI.

Light induced conversion of nitrogen dioxide into nitrous acid on submicron humic acid aerosol

Abstract: . The interactions of aerosols consisting of humic acids with gaseous nitrogen dioxide (NO2) were investigated under different light conditions in aerosol flow tube experiments at ambient pressure and temperature. The results show that NO2 is converted on the humic acid aerosol into nitrous acid (HONO), which is released from the aerosol and can be detected in the gas phase at the reactor exit. The formation of HONO on the humic acid aerosol is strongly activated by light: In the dark, the HONO-formation was below the detection limit, but it was increasing with the intensity of the irradiation with visible light. Under simulated atmospheric conditions with respect to the actinic flux, relative humidity and NO2-concentration, reactive uptake coefficients γrxn for the NO2→HONO conversion on the aerosol between γrxn 60% RH). The measured uptake coefficients for the NO2→HONO conversion are too low to explain the HONO-formation rates observed near the ground in rural and urban environments by the conversion of NO2→HONO on organic aerosol surfaces, even if one would assume that all aerosols consist of humic acid only. It is concluded that the processes leading to HONO formation on the Earth surface will have a much larger impact on the HONO-formation in the lowermost layer of the troposphere than humic materials potentially occurring in airborne particles.

Tomography-based Monte Carlo determination of radiative properties of reticulate porous ceramics

Abstract: A 3D digital representation of a reticulate porous ceramic (RPC) sample, generated by computer tomography (CT), is employed to determine its porosity, surface-to-volume ratio, and the minimum size of a representative elementary volume (REV) for continuum domain. Subsequently, the Monte Carlo (MC) ray-tracing technique is applied to calculate the extinction coefficient and scattering phase functions based on the probabilistic distribution functions of the extinction path-length and of the directional cosine of incident radiation. The methodology and governing equations are presented for diffusely and specularly reflecting surfaces. The isotropic assumption is justified by demonstrating that the extinction coefficient is directionally independent.

Structure and function of VEGF receptors

Abstract: Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis. VEGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor beta (TGFbeta), interleukins, or platelet-derived growth factors (PDGFs). VEGFs specifically interact with one or several receptor tyrosine kinases (RTKs), VEGF receptor-1, -2, and -3 (VEGFR-1, -2, -3), and with distinct coreceptors such as neuropilins or heparan sulfate glycosaminoglycans. VEGF receptors are classified as type V RTKs whose extracellular domains consists of seven immunoglobulin-like (Ig-like) domains. VEGF receptors are activated upon ligand-mediated dimerization. However, little was known about the mechanism of receptor activation at the structural level until recently. New data published by several labs for VEGF and the related type III RTKs now suggest that both ligand-receptor as well as homotypic receptor-receptor interactions stabilize ligand-induced receptor dimers. These data support the idea that structural changes induced in the extracellular domain upon ligand binding instigate transmembrane signaling by properly positioning the intracellular kinase domains in active receptor dimers.

Stabilization and operation of a Kerr-cat qubit

Abstract: Quantum superpositions of macroscopically distinct classical states-so-called Schrodinger cat states-are a resource for quantum metrology, quantum communication and quantum computation. In particular, the superpositions of two opposite-phase coherent states in an oscillator encode a qubit protected against phase-flip errors1,2. However, several challenges have to be overcome for this concept to become a practical way to encode and manipulate error-protected quantum information. The protection must be maintained by stabilizing these highly excited states and, at the same time, the system has to be compatible with fast gates on the encoded qubit and a quantum non-demolition readout of the encoded information. Here we experimentally demonstrate a method for the generation and stabilization of Schrodinger cat states based on the interplay between Kerr nonlinearity and single-mode squeezing1,3 in a superconducting microwave resonator4. We show an increase in the transverse relaxation time of the stabilized, error-protected qubit of more than one order of magnitude compared with the single-photon Fock-state encoding. We perform all single-qubit gate operations on timescales more than sixty times faster than the shortest coherence time and demonstrate single-shot readout of the protected qubit under stabilization. Our results showcase the combination of fast quantum control and robustness against errors, which is intrinsic to stabilized macroscopic states, as well as the potential of of these states as resources in quantum information processing5-8.