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Showing papers by "Pennsylvania State University published in 2002"


Journal ArticleDOI
28 Mar 2002-Nature
TL;DR: A review of the ecological impacts of recent climate change exposes a coherent pattern of ecological change across systems, from polar terrestrial to tropical marine environments.
Abstract: There is now ample evidence of the ecological impacts of recent climate change, from polar terrestrial to tropical marine environments. The responses of both flora and fauna span an array of ecosystems and organizational hierarchies, from the species to the community levels. Despite continued uncertainty as to community and ecosystem trajectories under global change, our review exposes a coherent pattern of ecological change across systems. Although we are only at an early stage in the projected trends of global warming, ecological responses to recent climate change are already clearly visible.

9,369 citations


Journal ArticleDOI
Robert H. Waterston1, Kerstin Lindblad-Toh2, Ewan Birney, Jane Rogers3  +219 moreInstitutions (26)
05 Dec 2002-Nature
TL;DR: The results of an international collaboration to produce a high-quality draft sequence of the mouse genome are reported and an initial comparative analysis of the Mouse and human genomes is presented, describing some of the insights that can be gleaned from the two sequences.
Abstract: The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

6,643 citations


Journal ArticleDOI
TL;DR: Evidence from epidemiological studies and RCTs will be reviewed, and recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation.
Abstract: fatty acids affect cardiac function (including antiarrhythmic effects), hemodynamics (cardiac mechanics), and arterial endothelial function have helped clarify potential mechanisms of action. The present Statement will address distinctions between plant-derived (-linolenic acid, C18:3n-3) and marine-derived (eicosapentaenoic acid, C20:5n-3 [EPA] and docosahexaenoic acid, C22:6n-3 [DHA]) omega-3 fatty acids. (Unless otherwise noted, the term omega-3 fatty acids will refer to the latter.) Evidence from epidemiological studies and RCTs will be reviewed, and recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation. This will be done in the context of recent guidance issued by the US Environmental Protection Agency and the Food and Drug Administration (FDA) about the presence of environmental contaminants in certain species of fish.

3,437 citations


Journal ArticleDOI
TL;DR: The Sloan Digital Sky Survey (SDSS) is an imaging and spectroscopic survey that will eventually cover approximately one-quarter of the celestial sphere and collect spectra of ≈106 galaxies, 100,000 quasars, 30,000 stars, and 30, 000 serendipity targets as discussed by the authors.
Abstract: The Sloan Digital Sky Survey (SDSS) is an imaging and spectroscopic survey that will eventually cover approximately one-quarter of the celestial sphere and collect spectra of ≈106 galaxies, 100,000 quasars, 30,000 stars, and 30,000 serendipity targets. In 2001 June, the SDSS released to the general astronomical community its early data release, roughly 462 deg2 of imaging data including almost 14 million detected objects and 54,008 follow-up spectra. The imaging data were collected in drift-scan mode in five bandpasses (u, g, r, i, and z); our 95% completeness limits for stars are 22.0, 22.2, 22.2, 21.3, and 20.5, respectively. The photometric calibration is reproducible to 5%, 3%, 3%, 3%, and 5%, respectively. The spectra are flux- and wavelength-calibrated, with 4096 pixels from 3800 to 9200 A at R ≈ 1800. We present the means by which these data are distributed to the astronomical community, descriptions of the hardware used to obtain the data, the software used for processing the data, the measured quantities for each observed object, and an overview of the properties of this data set.

2,422 citations


Journal ArticleDOI
TL;DR: The concept of "niche opportunity" was introduced by as discussed by the authors, which defines conditions that promote invasions in terms of resources, natural enemies, the physical environment, interactions between these factors, and the manner in which they vary in time and space.
Abstract: Community ecology theory can be used to understand biological invasions by applying recent niche concepts to alien species and the communities that they invade. These ideas lead to the concept of ‘niche opportunity', which defines conditions that promote invasions in terms of resources, natural enemies, the physical environment, interactions between these factors, and the manner in which they vary in time and space. Niche opportunities vary naturally between communities but might be greatly increased by disruption of communities, especially if the original community members are less well adapted to the new conditions. Recent niche theory clarifies the prediction that low niche opportunities (invasion resistance) result from high species diversity. Conflicting empirical patterns of invasion resistance are potentially explained by covarying external factors. These various ideas derived from community ecology provide a predictive framework for invasion ecology.

2,134 citations


Journal ArticleDOI
TL;DR: Many bioactive compounds are extranutritional constituents that typically occur in small quantities in foods and are grouped accordingly as phenolic compounds, including their subcategory, flavonoids as discussed by the authors.

2,091 citations


Journal ArticleDOI
TL;DR: In this article, the authors compared two perspectives of emotional labor as predictors of burnout beyond the effects of negative affectivity: job-focused emotional labor (work demands regarding emotion expression) and employee focused emotional labour (regulation of feelings and emotional expression).

2,003 citations


Journal ArticleDOI
TL;DR: This committee presents one key recommendation for community action to accompany the four recommendations for individual choices to reduce cancer risk, recognizing that a supportive social environment is indispensable if individuals at all levels of society are to have genuine opportunities to choose healthy behaviors.
Abstract: The American Cancer Society (ACS) publishes Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, policy, and community strategies and ultimately, to affect dietary and physical activity patterns among Americans. These Guidelines, published every 5 years, are developed by a national panel of experts in cancer research, prevention, epidemiology, public health, and policy, and as such, they represent the most current scientific evidence related to dietary and activity patterns and cancer risk. The ACS Guidelines include recommendations for individual choices regarding diet and physical activity patterns, but those choices occur within a community context that either facilitates or interferes with healthy behaviors. Community efforts are essential to create a social environment that promotes healthy food choices and physical activity. Therefore, this committee presents one key recommendation for community action to accompany the four recommendations for individual choices to reduce cancer risk. This recommendation for community action recognizes that a supportive social environment is indispensable if individuals at all levels of society are to have genuine opportunities to choose healthy behaviors. The ACS Guidelines are consistent with guidelines from the American Heart Association and the American Diabetes Association for the prevention of coronary heart disease and diabetes, as well as for general health promotion, as defined by the Department of Health and Human Services' 2005 Dietary Guidelines for Americans.

1,957 citations


Journal ArticleDOI
13 Nov 2002-JAMA
TL;DR: Results support the effectiveness and durability of the cognitive training interventions in improving targeted cognitive abilities and were of a magnitude equivalent to the amount of decline expected in elderly persons without dementia over 7- to 14-year intervals.
Abstract: ContextCognitive function in older adults is related to independent living and need for care. However, few studies have addressed whether improving cognitive functions might have short- or long-term effects on activities related to living independently.ObjectiveTo evaluate whether 3 cognitive training interventions improve mental abilities and daily functioning in older, independent-living adults.DesignRandomized, controlled, single-blind trial with recruitment conducted from March 1998 to October 1999 and 2-year follow-up through December 2001.Setting and ParticipantsVolunteer sample of 2832 persons aged 65 to 94 years recruited from senior housing, community centers, and hospital/clinics in 6 metropolitan areas in the United States.InterventionsParticipants were randomly assigned to 1 of 4 groups: 10-session group training for memory (verbal episodic memory; n = 711), or reasoning (ability to solve problems that follow a serial pattern; n = 705), or speed of processing (visual search and identification; n = 712); or a no-contact control group (n = 704). For the 3 treatment groups, 4-session booster training was offered to a 60% random sample 11 months later.Main Outcome MeasuresCognitive function and cognitively demanding everyday functioning.ResultsThirty participants were incorrectly randomized and were excluded from the analysis. Each intervention improved the targeted cognitive ability compared with baseline, durable to 2 years (P<.001 for all). Eighty-seven percent of speed-, 74% of reasoning-, and 26% of memory-trained participants demonstrated reliable cognitive improvement immediately after the intervention period. Booster training enhanced training gains in speed (P<.001) and reasoning (P<.001) interventions (speed booster, 92%; no booster, 68%; reasoning booster, 72%; no booster, 49%), which were maintained at 2-year follow-up (P<.001 for both). No training effects on everyday functioning were detected at 2 years.ConclusionsResults support the effectiveness and durability of the cognitive training interventions in improving targeted cognitive abilities. Training effects were of a magnitude equivalent to the amount of decline expected in elderly persons without dementia over 7- to 14-year intervals. Because of minimal functional decline across all groups, longer follow-up is likely required to observe training effects on everyday function.

1,878 citations


Journal ArticleDOI
TL;DR: The most striking finding across all domains was that self-perceptions of competence and subjective task values declined as children got older, although the extent and rate of decline varied across domains.
Abstract: This study extended previous research on changes in children's self-beliefs by documenting domain-specific growth trajectories for 761 children across grades 1 through 12 in a longitudinal study of perceptions of self-competence and task values. Hierarchical Linear Modeling was used to (1) describe changes in beliefs across childhood and adolescence within the domains of mathematics, language arts, and sports; (2) examine the impact of changes in competence beliefs on changes in values over time in the same domains; and (3) describe gender differences in mean levels and trajectories of change in competence beliefs and values. The most striking finding across all domains was that self-perceptions of competence and subjective task values declined as children got older, although the extent and rate of decline varied across domains. For example, in language arts, competence beliefs declined rapidly during the elementary school years, but then leveled off or increased to some extent; whereas the decline in self-competence beliefs in sports accelerated during the high school years. Significant gender differences in beliefs were found in most domains; however, the gender differences in developmental trajectories appeared to be domain specific rather than global. Importantly, the gender differences between boys and girls did not systematically increase with age, as predicted by some socialization perspectives. Adding competence beliefs as an explanatory variable to the model for task values revealed that changes in competence beliefs accounted for much of the age-related decline in task values. In addition, competence beliefs accounted for most of the gender differences in task values for language arts and sports.

1,574 citations


Journal ArticleDOI
TL;DR: A review of recent developments in the biosynthetic apparatus of metazoan organisms provides a resource for investigators interested in the incredible diversity and specificity of this process.
Abstract: ▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological processes, including growth control, signal transduction, cell adhesion, hemostasis, and lipid metabolism. The binding sites consist of relatively small tracts of variably sulfated glucosamine and uronic acid residues in specific arrangements. Their formation occurs in a tissue-specific fashion, generated by the action of a large family of enzymes involved in nucleotide sugar metabolism, polymer formation (glycosyltransferases), and chain processing (sulfotransferases and an epimerase). New insights into the specificity and organization of the biosynthetic apparatus have emerged from genetic studies of cultured cells, nematodes, fruit flies, zebrafish, rodents, and humans. This review covers recent developments in the field and provides a resource for investigators interested in the incredible dive...

Journal ArticleDOI
TL;DR: In this article, the authors propose that stronger team reward contingencies stimulate collaboration and that increasing collaboration weakens the effects of surface-level diversity on team outcomes but strengthens those of deep-level (psychological) diversity.
Abstract: Time serves as a medium for collaboration in teams, allowing members to exchange personal and task-related information. We propose that stronger team reward contingencies stimulate collaboration. As time passes, increasing collaboration weakens the effects of surface-level (demographic) diversity on team outcomes but strengthens those of deep-level (psychological) diversity. Also, perceived diversity transmits the impact of actual diversity on team social integration, which in turn affects task performance. Results from four waves of data on 144 student project teams support these propositions and the strong relevance of time to research on work team diversity.

Journal Article
TL;DR: The functional anatomy of the ankle complex as it relates to lateral ankle instability and to describe the pathomechanics and pathophysiology of acute lateral ankle sprains and chronic ankle instability are described.
Abstract: OBJECTIVE: To describe the functional anatomy of the ankle complex as it relates to lateral ankle instability and to describe the pathomechanics and pathophysiology of acute lateral ankle sprains and chronic ankle instability. DATA SOURCES: I searched MEDLINE (1985-2001) and CINAHL (1982-2001) using the key words ankle sprain and ankle instability. DATA SYNTHESIS: Lateral ankle sprains are among the most common injuries incurred during sports participation. The ankle functions as a complex with contributions from the talocrural, subtalar, and inferior tibiofibular joints. Each of these joints must be considered in the pathomechanics and pathophysiology of lateral ankle sprains and chronic ankle instability. Lateral ankle sprains typically occur when the rearfoot undergoes excessive supination on an externally rotated lower leg. Recurrent ankle sprain is extremely common; in fact, the most common predisposition to suffering a sprain is the history of having suffered a previous ankle sprain. Chronic ankle instability may be due to mechanical instability, functional instability, or most likely, a combination of these 2 phenomena. Mechanical instability may be due to specific insufficiencies such as pathologic laxity, arthrokinematic changes, synovial irritation, or degenerative changes. Functional instability is caused by insufficiencies in proprioception and neuromuscular control. CONCLUSIONS/RECOMMENDATIONS: Lateral ankle sprains are often inadequately treated, resulting in frequent recurrence of ankle sprains. Appreciation of the complex anatomy and mechanics of the ankle joint and the pathomechanics and pathophysiology related to acute and chronic ankle instability is integral to the process of effectively evaluating and treating ankle injuries.

Journal ArticleDOI
TL;DR: A survey of property owners in Vilas County, Wisconsin revealed the importance of symbolic meanings as underpinning both place satisfaction, conceptualized as an attitude toward a setting, and attachment, conceptualised as personal identification with a setting as discussed by the authors.
Abstract: Sense-of-place writings have proliferated in recent years, yet research suffers from a relative lack of construct clarity and hypothesis testing. This research presents a model of sense of place based in conventional social psychology: cognitions, attitudes, identities, and behavioral intentions located in and fundamentally about place. A survey of property owners in Vilas County, Wisconsin, revealed the importance of symbolic meanings as underpinning both place satisfaction, conceptualized as an attitude toward a setting, and attachment, conceptualized as personal identification with a setting. In turn, attachment, satisfaction, and meanings all have independent effects on willingness to engage in behaviors that maintain or enhance valued attributes of the setting.

Journal ArticleDOI
TL;DR: It is discovered that the hepatitis C virus (HCV) envelope glycoprotein E2 binds to human hepatoma cell lines independently of the previously proposed HCV receptor CD81, and the receptor responsible for E2 binding to human hepatic cells is identified as the human scavenger receptor class B type I (SR‐BI).
Abstract: We discovered that the hepatitis C virus (HCV) envelope glycoprotein E2 binds to human hepatoma cell lines independently of the previously proposed HCV receptor CD81. Comparative binding studies using recombinant E2 from the most prevalent 1a and 1b genotypes revealed that E2 recognition by hepatoma cells is independent from the viral isolate, while E2–CD81 interaction is isolate specific. Binding of soluble E2 to human hepatoma cells was impaired by deletion of the hypervariable region 1 (HVR1), but the wild-type phenotype was recovered by introducing a compensatory mutation reported previously to rescue infectivity of an HVR1-deleted HCV infectious clone. We have identified the receptor responsible for E2 binding to human hepatic cells as the human scavenger receptor class B type I (SR-BI). E2–SR-BI interaction is very selective since neither mouse SR-BI nor the closely related human scavenger receptor CD36, were able to bind E2. Finally, E2 recognition by SR-BI was competed out in an isolate-specific manner both on the hepatoma cell line and on the human SR-BI-transfected cell line by an anti-HVR1 monoclonal antibody.

Journal ArticleDOI
TL;DR: In this article, the authors discuss the needs for fundamental changes in the energy system for major efficiency improvements in terms of global resource limitation and sustainable development, and discuss the strategies and options of fuel processors depend on the type of fuel cells and applications.

Journal ArticleDOI
TL;DR: In this paper, the authors describe an automated algorithm for selecting quasar candidates for optical spectroscopy in the Sloan Digital Sky Survey, which is sensitive to quasars at all redshifts lower than z ~ 5.8.
Abstract: We describe the algorithm for selecting quasar candidates for optical spectroscopy in the Sloan Digital Sky Survey. Quasar candidates are selected via their nonstellar colors in ugriz broadband photometry and by matching unresolved sources to the FIRST radio catalogs. The automated algorithm is sensitive to quasars at all redshifts lower than z ~ 5.8. Extended sources are also targeted as low-redshift quasar candidates in order to investigate the evolution of active galactic nuclei (AGNs) at the faint end of the luminosity function. Nearly 95% of previously known quasars are recovered (based on 1540 quasars in 446 deg2). The overall completeness, estimated from simulated quasars, is expected to be over 90%, whereas the overall efficiency (quasars/quasar candidates) is better than 65%. The selection algorithm targets ultraviolet excess quasars to i* = 19.1 and higher redshift (z 3) quasars to i* = 20.2, yielding approximately 18 candidates deg-2. In addition to selecting "normal" quasars, the design of the algorithm makes it sensitive to atypical AGNs such as broad absorption line quasars and heavily reddened quasars.

Journal ArticleDOI
TL;DR: In this article, an analytical expression for the optimal power flow from a rectified piezoelectric device is derived, and an energy harvesting circuit consisting of an AC-DC rectifier with an output capacitor, an electrochemical battery, and a switch-mode DC-DC converter that controls the energy flow into the battery.
Abstract: This paper describes an approach to harvesting electrical energy from a mechanically excited piezoelectric element. A vibrating piezoelectric device differs from a typical electrical power source in that it has a capacitive rather than inductive source impedance, and may be driven by mechanical vibrations of varying amplitude. An analytical expression for the optimal power flow from a rectified piezoelectric device is derived, and an "energy harvesting" circuit is proposed which can achieve this optimal power flow. The harvesting circuit consists of an AC-DC rectifier with an output capacitor, an electrochemical battery, and a switch-mode DC-DC converter that controls the energy flow into the battery. An adaptive control technique for the DC-DC converter is used to continuously implement the optimal power transfer theory and maximize the power stored by the battery. Experimental results reveal that use of the adaptive DC-DC converter increases power transfer by over 400% as compared to when the DC-DC converter is not used.

Journal ArticleDOI
TL;DR: This work shows that the Web self-organizes and its link structure allows efficient identification of communities and is significant because no central authority or process governs the formation and structure of hyperlinks.
Abstract: The vast improvement in information access is not the only advantage resulting from the increasing percentage of hyperlinked human knowledge available on the Web. Additionally, much potential exists for analyzing interests and relationships within science and society. However, the Web's decentralized and unorganized nature hampers content analysis. Millions of individuals operating independently and having a variety of backgrounds, knowledge, goals and cultures author the information on the Web. Despite the Web's decentralized, unorganized, and heterogeneous nature, our work shows that the Web self-organizes and its link structure allows efficient identification of communities. This self-organization is significant because no central authority or process governs the formation and structure of hyperlinks.

Journal ArticleDOI
19 Sep 2002-Nature
TL;DR: A new class of all-organic field-type EAP composites is reported, which can exhibit high elastic energy densities induced by an electric field of only 13 V µm-1, and could find applications as artificial muscles, ‘smart skins’ for drag reduction, and in microfluidic systems for drug delivery.
Abstract: Electroactive polymers (EAPs) can behave as actuators, changing their shape in response to electrical stimulation. EAPs that are controlled by external electric fields--referred to here as field-type EAPs--include ferroelectric polymers, electrostrictive polymers, dielectric elastomers and liquid crystal polymers. Field-type EAPs can exhibit fast response speeds, low hysteresis and strain levels far above those of traditional piezoelectric materials, with elastic energy densities even higher than those of piezoceramics. However, these polymers also require a high field (>70 V micro m(-1)) to generate such high elastic energy densities (>0.1 J cm(-3); refs 4, 5, 9, 10). Here we report a new class of all-organic field-type EAP composites, which can exhibit high elastic energy densities induced by an electric field of only 13 V micro m(-1). The composites are fabricated from an organic filler material possessing very high dielectric constant dispersed in an electrostrictive polymer matrix. The composites can exhibit high net dielectric constants while retaining the flexibility of the matrix. These all-organic actuators could find applications as artificial muscles, 'smart skins' for drag reduction, and in microfluidic systems for drug delivery.

Journal ArticleDOI
TL;DR: In this article, a mesoporous molecular sieve of MCM-41 type (MCM41-PEI) has been used as a CO2 adsorbent.
Abstract: The objective of the work presented here is to develop a nanoporous solid adsorbent which can serve as a “molecular basket” for CO2 in the condensed form Polyethylenimine (PEI)-modified mesoporous molecular sieve of MCM-41 type (MCM-41-PEI) has been prepared and tested as a CO2 adsorbent The physical properties of the adsorbents were characterized by X-ray powder diffraction (XRD), N2 adsorption/desorption, and thermogravimetric analysis (TGA) The characterizations indicated that the structure of the MCM-41 was preserved after loading the PEI, and the PEI was uniformly dispersed into the channels of the molecular sieve The CO2 adsorption/desorption performance was tested in a flow system using a microbalance to track the weight change The mesoporous molecular sieve had a synergetic effect on the adsorption of CO2 by PEI A CO2 adsorption capacity as high as 215 mg-CO2/g-PEI was obtained with MCM-41-PEI-50 at 75 °C, which is 24 times higher than that of the MCM-41 and is even 2 times that of the pure

Journal ArticleDOI
TL;DR: This paper draws upon institutional theory and the conceptual lens of structuring and metastructuring actions to explain the importance of three factors-top management championship, strategic investment rationale, and extent of coordination-in achieving higher levels of Web assimilation within an organization.
Abstract: The global reach of the Web technological platform, along with the range of services that it supports, makes it a powerful business resource. However, realization of operational and strategic benefits is contingent on effective assimilation of this type III IS innovation. This paper draws upon institutional theory and the conceptual lens of structuring and metastructuring actions to explain the importance of three factors-top management championship, strategic investment rationale, and extent of coordination-in achieving higher levels of Web assimilation within an organization. Survey data are utilized to test a nomological network of relationships among these factors and the extent of organizational assimilation of Web technologies.

Journal ArticleDOI
TL;DR: Spectral data related to water adsorbed in the noncrystalline regions of starches provided a better classification of irradiated starches with 5 partial least-squares (PLS) factors in the multivariate model.
Abstract: Fourier transform infrared (FTIR) and Fourier transform Raman (FT-Raman) methods were used for rapid characterization and classification of selected irradiated starch samples. Biochemical changes due to irradiation were detected using the two vibrational spectroscopic techniques, and canonical variate analysis (CVA) was applied to the spectral data for discriminating starch samples based on the extent of irradiation. The O−H (3000−3600 cm-1) stretch, C−H (2800−3000 cm-1) stretch, the skeletal mode vibration of the glycosidic linkage (900−950 cm-1) in both Raman and infrared spectra, and the infrared band of water adsorbed in the amorphous parts of starches (1550−1750 cm-1) were employed in classification analysis of irradiated starches. Spectral data related to water adsorbed in the noncrystalline regions of starches provided a better classification of irradiated starches with 5 partial least-squares (PLS) factors in the multivariate model. Keywords: Starch irradiation; FT-Raman spectroscopy; FTIR spectro...

Journal ArticleDOI
TL;DR: An analysis of single nucleotide polymorphisms with allele frequencies that were determined in three populations provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation.
Abstract: Natural selection, which can be defined as the differential contribution of genetic variants to future generations (Aquadro et al. 2001), is the driving force of Darwinian evolution. Despite intense research, only a relatively small number of regions and genes have been directly implicated as targets of selection in the human genome (Kitano and Saitou 1999; Rana et al. 1999; Huttley et al. 2000; Hollox et al. 2001; Hull et al. 2001; Hurst and Pal 2001; Koda et al. 2001; Sullivan et al. 2001; Tishkoff et al. 2001; Baum et al. 2002; Fullerton et al. 2002; Gilad et al. 2002; Hamblin et al. 2002). A more comprehensive and genomic understanding of how and where natural selection has shaped patterns of genetic variation may provide important insights into the mechanisms of evolutionary change (Otto 2000), guide selection of loci for inclusion in population genetic studies (Vitalis et al. 2001), facilitate the annotation of functionally significant genomic regions (Nielsen 2001), and help elucidate genotype-phenotype correlations in complex diseases (Przeworski et al. 2000; Nielsen 2001). Detecting unambiguous evidence for natural selection remains challenging because the effect of selection on the distribution of genetic variation can be mimicked by population demographic history (i.e., the size, structure, and mating pattern of a population). For instance, both adaptive hitchhiking and population expansion can cause an excess of rare variants observed in DNA sequence data compared with what is expected under a standard neutral model (Tajima 1989; Przeworski et al. 2000). Despite these difficulties, the recent deluge of publicly available single nucleotide polymorphisms (SNPs) provides an exciting opportunity to identify genome-wide signatures of selection (Sunyaev et al. 2000; Fay et al. 2001; Sachidanandam et al. 2001). To this end, examining the variation in SNP allele frequencies between populations, which can be quantified by the statistic FST, is a promising strategy for detecting signatures of natural selection (Lewontin and Krakauer 1973; Rana et al. 1999; Hollox et al. 2001; Fullerton et al. 2002; Gilad et al. 2002; Hamblin et al. 2002). Under selective neutrality, FST is determined by genetic drift, which will affect all loci across the genome in a similar and predictable fashion. On the other hand, natural selection is a locus-specific force that can cause systematic deviations in FST values for a selected gene and nearby genetic markers. For example, geographically restricted directional selection may lead to an increase in FST of a selected locus, whereas balancing or species-wide directional selection may lead to a decrease in FST compared with neutrally evolving loci (Cavalli-Sforza 1966; Bowcock et al. 1991; Andolfatto 2001). Previous studies that have attempted to identify natural selection based on patterns of population differentiation relied on simulations to obtain the expected distribution of FST under selective neutrality (Lewontin and Krakauer 1973; Bowcock et al. 1991; Beaumont and Nichols 1996). However, the simulated distribution of FST strongly depends on the assumed population demographic history, which is rarely known with any degree of certainty. As an expanding number of SNPs are genotyped across multiple populations, a complimentary approach that does not require tenuous assumptions about population demographic history is now becoming feasible. Specifically, by sampling a large number of SNPs throughout the genome, loci that have been affected by natural selection can simply be identified as outliers in the extreme tails of the empirical distribution of FST (Cavalli-Sforza 1966; Black et al. 2001; Goldstein and Chikhi 2002). Recently, this strategy has been used to infer natural selection in the CAPN10 gene; however, the empirical distribution of FST contained <100 loci (Fullerton et al. 2002). In this work, we describe an analysis of 26,530 SNPs with allele frequencies that were determined in three populations: African-American, East Asian, and European-American. The density of this SNP allele frequency map provides a unique and powerful opportunity to interrogate the genome for signatures of natural selection. Through a variety of analyses, we have found statistically significant evidence supporting the hypothesis that selection has influenced extant patterns of human genetic variation. Furthermore, we have identified 174 candidate genes that demonstrate signatures of selection when contrasted to the empirical genome-wide distribution of FST. This analysis provides the conceptual foundation for constructing a high-resolution natural selection map, which will be an important resource in understanding the recent evolutionary history of our species, and will facilitate detailed studies on the identified candidate genes.

Journal ArticleDOI
TL;DR: The authors compared samples of publicly and privately held bank holding companies to examine whether the high frequency of small earnings increases relative to small earnings decreases reported by public firms is attributable to earnings management.
Abstract: This study compares samples of publicly and privately held bank holding companies to examine whether the high frequency of small earnings increases relative to small earnings decreases reported by public firms is attributable to earnings management. We expect public banks' shareholders to be more likely than private banks' shareholders to rely on simple earnings‐based heuristics in evaluating firm performance, so we expect public banks to have more incentives to report steadily increasing earnings. Consistent with this expectation, we find that relative to private banks, public banks: (1) report fewer small earnings declines, (2) are more likely to use the loan loss provision and security gain realizations to eliminate small earnings decreases, and (3) report longer strings of consecutive earnings increases. These results suggest that the asymmetric pattern of more small earnings increases than decreases, first documented by Burgstahler and Dichev (1997), is attributable to earnings management and is not ...

Journal ArticleDOI
TL;DR: Giroux argues that corporate culture functions largely to either ignore or cancel out social injustices in the existing social order by overriding the democratic impulses and practices of civil society through an emphasis on the unbridled workings of market relations as mentioned in this paper.
Abstract: In this article, Henry Giroux addresses the corrosive effects of corporate culture on the academy and recent attempts by faculty and students to resist the corporatization of higher education. Giroux argues that neoliberalism is the most dangerous ideology of the current historical moment. He shows that civic discourse has given way to the language of commercialization, privatization, and deregulation and that, within the language and images of corporate culture, citizenship is portrayed as an utterly privatized affair that produces self-interested individuals. He maintains that corporate culture functions largely to either ignore or cancel out social injustices in the existing social order by overriding the democratic impulses and practices of civil society through an emphasis on the unbridled workings of market relations. Giroux suggests that these trends mark a hazardous turn in U.S. society, one that threatens our understanding of democracy and affects the ways we address the meaning and purpose of hi...

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TL;DR: This is the first investigation to demonstrate changes in translation initiation and skeletal muscle protein synthesis in response to AMPK activation.

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TL;DR: Evidence is provided that differences in health risks among LGB youth are mediated by victimization at school, and such victimization of L GB youth is associated with health risk behaviors.

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TL;DR: In this paper, the authors identify new structures in the halo of the Milky Way from positions, colors, and magnitudes of five million stars detected in the Sloan Digital Sky Survey.
Abstract: We identify new structures in the halo of the Milky Way from positions, colors, and magnitudes of five million stars detected in the Sloan Digital Sky Survey. Most of these stars are within 126 of the celestial equator. We present color-magnitude diagrams (CMDs) for stars in two previously discovered, tidally disrupted structures. The CMDs and turnoff colors are consistent with those of the Sagittarius dwarf galaxy, as had been predicted. In one direction, we are even able to detect a clump of red stars, similar to that of the Sagittarius dwarf, from stars spread across 110 deg2 of sky. Focusing on stars with the colors of F turnoff objects, we identify at least five additional overdensities of stars. Four of these may be pieces of the same halo structure, which would cover a region of the sky at least 40° in diameter, at a distance of 11 kpc from the Sun (18 kpc from the center of the Galaxy). The turnoff is significantly bluer than that of thick-disk stars, yet the stars lie closer to the Galactic plane than a power-law spheroid predicts. We suggest two models to explain this new structure. One possibility is that this new structure could be a new dwarf satellite of the Milky Way, hidden in the Galactic plane and in the process of being tidally disrupted. The other possibility is that it could be part of a disklike distribution of stars which is metal-poor, with a scale height of approximately 2 kpc and a scale length of approximately 10 kpc. The fifth overdensity, which is 20 kpc away, is some distance from the Sagittarius dwarf streamer orbit and is not associated with any known Galactic structure. We have tentatively identified a sixth overdensity in the halo. If this sixth structure is instead part of a smooth distribution of halo stars (the spheroid), then the spheroid must be very flattened, with axial ratio q = 0.5. It is likely that there are many smaller streams of stars in the Galactic halo.

Journal ArticleDOI
TL;DR: In this article, a developmental theory of voter turnout is proposed, based on the observation that most young citizens start their political lives as habitual nonvoters but they vary in how long it takes to develop into habitual voters.
Abstract: This paper reframes our inquiry into voter turnout by making aging the lens through which the traditional resource and cost measures of previous turnout research are viewed, thereby making three related contributions. (1) I offer a developmental theory of turnout. This framework follows from the observation that most citizens are habitual voters or habitual nonvoters (they display inertia). Most young citizens start their political lives as habitual nonvoters but they vary in how long it takes to develop into habitual voters. With this transition at the core of the framework, previous findings concerning costs and resources can easily be integrated into developmental theory. (2) I make a methodological contribution by applying latent growth curve models to panel data. (3) Finally, the empirical analyses provide the developmental theory with strong support and also provide a better understanding of the roles of aging, parenthood, partisanship, and geographic mobility.