Philips

About: Philips is a company organization based out in Vantaa, Finland. It is known for research contribution in the topics: Signal & Layer (electronics). The organization has 68260 authors who have published 99663 publications receiving 1882329 citations. The organization is also known as: Koninklijke Philips Electronics N.V. & Royal Philips Electronics.

Metabolic imaging of patients with intracranial tumors: H-1 MR spectroscopic imaging and PET.

Abstract: Hydrogen-1 magnetic resonance (MR) spectroscopic images of patients with intracranial tumors were obtained. Metabolite maps of N-acetyl aspartate, choline, lactate, and creatine concentrations were reconstructed with a nominal spatial resolution of 7 mm and a section thickness of 25 mm. The metabolite maps showed variations in metabolite concentrations across the tumor. In one patient, it was observed that choline concentration was increased in one part of the tumor but decreased in another part. In another patient, the concentration of N-acetyl aspartate was extremely low in one part of the tumor but only slightly increased in another part of the tumor. Lactate was observed in all patients. In one patient, a combined measurement made with positron emission tomography (PET) and MR spectroscopic imaging was performed. This demonstrated that increased lactate concentration measured with H-1 MR spectroscopic imaging corresponded topographically with increased glucose uptake measured with fluorine-18 fluoro-2-deoxyglucose PET. Combined MR spectroscopic and PET measurements provide an opportunity to investigate, in greater detail than before, glucose uptake and catabolism by intracranial tumors.

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Abstract: Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the development of resistance. In an effort to identify new potential antimalarials, we have undertaken a lead optimization program around our previously identified triazolopyrimidine-based series of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. The X-ray structure of PfDHODH was used to inform the medicinal chemistry program allowing the identification of a potent and selective inhibitor (DSM265) that acts through DHODH inhibition to kill both sensitive and drug resistant strains of the parasite. This compound has similar potency to chloroquine in the humanized SCID mouse P. falciparum model, can be synthesized by a simple route, and rodent pharmacokinetic studies demonstrated it has excellent oral bioavailability, a long half-life and low clearance. These studies have identified the first candidate in the triazolopyrimidine series to meet previously established progression criteria for efficacy and ADME properties, justifying further development of this compound toward clinical candidate status.

Early warning real-time security system

Abstract: An early-warning security system for monitoring and tracking in real-time the activities and movements associated with prescribed personnel, personal property, mobile vehicles, and buildings. The system comprises a plurality of in situ local controllers having a microprocessor and a coordinated plurality of conspicuous and clandestine digital video cameras for continuously producing digital audio and visual signals, uplinking such signals via a suitable wireless telecommunications device to a satellite, general packet radio service, the Internet, intranet or extranet, and then downlinking these signals to a plurality of control centers for recording and analysis thereof. Uplinking of these digital signals may occur continuously or may be activated by a manual or predefined trigger event. Preventative or remedial action is immediately taken when perturbations from normal behavior or activities are observed in the recorded audio and visual signals.

Image guided surgery system

Abstract: The invention relates to an image guided surgery system, having an optical position measuring system which includes a detector arrangement (3) and a marker arrangement (4, 5, 6). In known optical position measuring systems, for example comprising two cameras and three LEDs per marker arrangement, a direct line of sight must continuously exist between the detector arrangement (3) and the marker arrangement (4, 5, 6) in order to ensure reliable and continuous operation of the system and to supply the surgeon continuously with information concerning the current position of an instrument or another part provided with a marker arrangement during the treatment. Blocking of the direct line of sight has a negative effect on the operation of the position measuring system. These drawbacks are avoided according to the invention in that at least one mirror (7) is provided in order to establish an indirect line of sight (5i, 6i) between the detector arrangement (3) and the marker arrangement (4, 5, 6). It is thus ensured that at least one line of sight exists at all times.

Wrapper design for embedded core test

Abstract: A wrapper is a thin shell around the core, that provides the switching between functional, and core-internal and core-external test modes. Together with a test access mechanism (TAM), the core test wrapper forms the test access infrastructure to embedded reusable cores. Various company-internal as well as industry-wide standardized but scalable wrappers have been proposed. This paper deals with the design of such core test wrappers. It gives a general architecture for wrappers, and describes how a wrapper can be built up from a library of wrapper cells which are selected on basis of the terminal types of the core. We show that the ordering and partitioning of wrapper cells and core-internal scan chains over TAM chains determine the test time of the core. An heuristic approach for the NP-hard problem of partitioning the TAM chain items for minimal test time is presented and its usage is illustrated by means of an example. Finally we sketch how wrapper generation and verification can be automated.