Pierre-and-Marie-Curie University

About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.

Sources of nitrate in rivers draining sixteen watersheds in the northeastern U.S.: Isotopic constraints

Abstract: The feasibility of using nitrogen and oxygen isotope ratios of nitrate (NO 3 − ) for elucidating sources and transformations of riverine nitrate was evaluated in a comparative study of 16 watersheds in the northeastern U.S.A. Stream water was sampled repeatedly at the outlets of the watersheds between January and December 1999 for determining concentrations, δ 15N values, and δ 180 values of riverine nitrate.

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

Abstract: Alzheimer's disease, a fatal neurodegenerative disorder of unknown aetiology, is usually considered to be a single disorder because of the general uniformity of the disease phenotype. Two recent genetic linkage studies revealed co-segregation of familial Alzheimer disease with the D21S1/S11 and D21S16 loci on chromosome 21. But two other studies, one of predominantly multiplex kindreds with a late age-of-onset, the other of a cadre of kindreds with a unique Volga German ethnic origin, found absence of linkage at least to D21S1/S11. So far it has not been possible to discern whether these conflicting reports reflect aetiological heterogeneity, differences in methods of pedigree selection, effects of confounding variables in the analysis (for example, diagnostic errors, assortative matings), or true non-replication. To resolve this issue, we have now examined the inheritance of five polymorphic DNA markers from the proximal long arm of chromosome 21 in a large unselected series of pedigrees with familial Alzheimer's disease. Our data suggest that Alzheimer's disease is not a single entity, but rather results from genetic defects on chromosome 21 and from other genetic or nongenetic factors.

Proposed Realization of the Dicke-Model Quantum Phase Transition in an Optical Cavity QED System

Abstract: The Dicke model describing an ensemble of two-state atoms interacting with a single quantized mode of the electromagnetic field (with omission of the Â^2 term) exhibits a zero-temperature phase transition at a critical value of the dipole coupling strength. We propose a scheme based on multilevel atoms and cavity-mediated Raman transitions to realize an effective Dicke model operating in the phase transition regime. Optical light from the cavity carries signatures of the critical behavior, which is analyzed for the thermodynamic limit where the number of atoms is very large.

Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Abstract: Advances in molecular genetics present new opportunities and challenges for cardiologists who manage patients and families with cardiomyopathies. The aims of this position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases are to review the general issues related to genetic counselling, family screening and genetic testing in families with a cardiomyopathy, and to provide key messages and suggestions for clinicians involved in their management.