Pierre-and-Marie-Curie University

About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.

The Physics of the B Factories

Abstract: This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C.

On dynamic and thermodynamic components of cloud changes

Abstract: Clouds are sensitive to changes in both the large-scale circulation and the thermodynamic structure of the atmosphere. In the tropics, temperature changes that occur on seasonal to decadal time scales are often associated with circulation changes. Therefore, it is difficult to determine the part of cloud variations that results from a change in the dynamics from the part that may result from the temperature change itself. This study proposes a simple framework to unravel the dynamic and non-dynamic (referred to as thermodynamic) components of the cloud response to climate variations. It is used to analyze the contrasted response, to a prescribed ocean warming, of the tropically-averaged cloud radiative forcing (CRF) simulated by the ECMWF, LMD and UKMO climate models. In each model, the dynamic component largely dominates the CRF response at the regional scale, but this is the thermodynamic component that explains most of the average CRF response to the imposed perturbation. It is shown that this component strongly depends on the behaviour of the low-level clouds that occur in regions of moderate subsidence (e.g. in the trade wind regions). These clouds exhibit a moderate sensitivity to temperature changes, but this is mostly their huge statistical weight that explains their large influence on the tropical radiation budget. Several propositions are made for assessing the sensitivity of clouds to changes in temperature and in large-scale motions using satellite observations and meteorological analyses on the one hand, and mesoscale models on the other hand.

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

Abstract: The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) is of global concern: the virus has caused severe respiratory illness, with 111 confirmed cases and 52 deaths at the time of this article's publication. Therapeutic interventions have not been evaluated in vivo; thus, patient management relies exclusively on supportive care, which, given the high case-fatality rate, is not highly effective. The rhesus macaque is the only known model organism for MERS-CoV infection, developing an acute localized to widespread pneumonia with transient clinical disease that recapitulates mild to moderate human MERS-CoV cases. The combination of interferon-α2b and ribavirin was effective in reducing MERS-CoV replication in vitro; therefore, we initiated this treatment 8 h after inoculation of rhesus macaques. In contrast to untreated, infected macaques, treated animals did not develop breathing abnormalities and showed no or very mild radiographic evidence of pneumonia. Moreover, treated animals showed lower levels of systemic (serum) and local (lung) proinflammatory markers, in addition to fewer viral genome copies, distinct gene expression and less severe histopathological changes in the lungs. Taken together, these data suggest that treatment of MERS-CoV infected rhesus macaques with IFN-α2b and ribavirin reduces virus replication, moderates the host response and improves clinical outcome. As these two drugs are already used in combination in the clinic for other infections, IFN-α2b and ribavirin should be considered for the management of MERS-CoV cases.