Institution
Pierre-and-Marie-Curie University
Education•Paris, France•
About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.
Papers published on a yearly basis
Papers
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TL;DR: In this article, a three dimensional model of elastic periodic plate when the thickness e of the plate and the size ω of the periods are small is studied and convergence proof is carried out.
Abstract: This paper is devoted to the study of a three dimensional model of elastic periodic plate when the thickness e of the plate and the size ω of the periods are small. In the three studied limits (e 0 then ω 0), (ω 0 then e 0) and lately (e and ω 0 together) the three dimensional equation of elasticity are approached by the two dimensional general equations of a linear anisotropic plate, the stretching and bending being coupled. This study points out the importance of the ratio of the two small parameters, indeed the moduli occuring in the two dimensional equations are different in the three limits. In each case a convergence proof is carried out.
332 citations
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TL;DR: In this article, the authors identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals, and 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues.
Abstract: To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
332 citations
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TL;DR: It is shown that chromosome rearrangements can occur during BIR if dissociation and reinvasion occur within dispersed repeated sequences, and that this dynamic process could function to promote gene conversion by capture of the displaced invading strand at two-ended DSBs to prevent BIR.
Abstract: DNA double-strand breaks (DSBs) are potentially lethal lesions that arise spontaneously during normal cellular metabolism, as a consequence of environmental genotoxins or radiation, or during programmed recombination processes. Repair of DSBs by homologous recombination generally occurs by gene conversion resulting from transfer of information from an intact donor duplex to both ends of the break site of the broken chromosome. In mitotic cells, gene conversion is rarely associated with reciprocal exchange and thus limits loss of heterozygosity for markers downstream of the site of repair and restricts potentially deleterious chromosome rearrangements. DSBs that arise by replication fork collapse or by erosion of uncapped telomeres have only one free end and are thought to repair by strand invasion into a homologous duplex DNA followed by replication to the chromosome end (break-induced replication, BIR). BIR from one of the two ends of a DSB would result in loss of heterozygosity, suggesting that BIR is suppressed when DSBs have two ends so that repair occurs by the more conservative gene conversion mechanism. Here we show that BIR can occur by several rounds of strand invasion, DNA synthesis and dissociation. We further show that chromosome rearrangements can occur during BIR if dissociation and reinvasion occur within dispersed repeated sequences. This dynamic process could function to promote gene conversion by capture of the displaced invading strand at two-ended DSBs to prevent BIR.
332 citations
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University of Western Australia1, Alfred I. duPont Hospital for Children2, Michigan State University3, University of Illinois at Chicago4, Emory University5, Pierre-and-Marie-Curie University6, University of Amsterdam7, National Heart Foundation of Australia8, University of St Andrews9, Ludwig Maximilian University of Munich10, University of the Witwatersrand11, University of São Paulo12, Erasmus University Rotterdam13, Aberdeen Royal Infirmary14, Royal Prince Alfred Hospital15, The Chinese University of Hong Kong16, Osaka University17
TL;DR: Recommendations on treatment are based on risk stratification, management of non-cholesterol risk factors, and safe and effective use of LDL lowering therapies, and the use of emerging therapies for FH is foreshadowed.
331 citations
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TL;DR: Investigation of the expression and function of another microneme protein recently identified in Plasmodium falciparum sporozoites, apical membrane antigen 1 (AMA-1), finds that interfering with sporozoite proteolytic processing may constitute a valuable strategy to prevent hepatocyte infection.
331 citations
Authors
Showing all 34671 results
Name | H-index | Papers | Citations |
---|---|---|---|
Zhong Lin Wang | 245 | 2529 | 259003 |
Guido Kroemer | 236 | 1404 | 246571 |
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
J. E. Brau | 162 | 1949 | 157675 |
E. Hivon | 147 | 403 | 118440 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Simon Prunet | 141 | 434 | 96314 |
H. J. McCracken | 140 | 579 | 71091 |
G. Calderini | 139 | 1734 | 102408 |
Stefano Giagu | 139 | 1651 | 101569 |
Jean-Paul Kneib | 138 | 805 | 89287 |
G. Marchiori | 137 | 1590 | 94277 |
J. Ocariz | 136 | 1562 | 95905 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
Alexis Brice | 135 | 870 | 83466 |